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DRISTAN® N.D. DRISTAN® N.D. EXTRA STRENGTH Whitehall-Robins Acetaminophen – Pseudoephedrine HCl Analgesic – Decongestant Indications And Clinical Uses: For the symptomatic relief of colds, sinusitis, nasal congestion, sneezing, runny nose, fever, headache, minor aches and pains. Contra-Indications: Hypersensitivity to any of the components. Patients receiving MAO inhibitors. Precautions: Use with caution on elderly patients or those with hypertension, diabetes, glaucoma, coronary artery disease, hyperthyroidism, prostatic hypertrophy and patients receiving MAO…

DOLOBID® Frosst Diflunisal Analgesic – Anti-inflammatory Action And Clinical Pharmacology: Diflunisal is a nonsteroidal drug with analgesic, anti-inflammatory and antipyretic properties. The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known; however, it appears to be a peripherally acting analgesic drug. Diflunisal is a prostaglandin synthetase inhibitor. In animals, prostaglandin sensitize afferent nerves and potentiate the action of bradykinin in inducing pain. Since prostaglandins are known…

DOXORUBICIN HYDROCHLORIDE INJECTION USP Novopharm Antineoplastic Agent Action And Clinical Pharmacology: Doxorubicin is the hydrochloric acid salt of a glycoside antibiotic produced by S. peucetius var. caesiu. Although not completely elucidated, the mechanism of action of doxorubicin is related mainly to its ability to bind specifically with DNA, by intercalation between adjacent base pairs of the double-helical structure, thereby inhibiting nucleic acid synthesis. Binding to cell membranes as well as…

DOXORUBICIN HCl FOR INJECTION USP Faulding Antineoplastic Agent Action And Clinical Pharmacology: The precise mechanism(s) of the antineoplastic action of doxorubicin is not fully understood. Experimental evidence indicates that doxorubicin forms a complex with DNA by intercalation between base pairs, causing inhibition of DNA synthesis and DNA-dependent RNA synthesis by the resulting template disordering and steric obstruction. Doxorubicin also inhibits protein synthesis. Doxorubicin is active throughout the cell cycle including…

DOAN’S® Backache Pills Novartis Consumer Health Magnesium Salicylate Analgesic Indications And Clinical Uses: For quick relief of muscular backache pain. Manufacturers’ Warnings In Clinical States: Pregnancy and Lactation: Consult a physician before taking this drug during the last 3 months of pregnancy or if nursing. Package contains enough drug to seriously harm a child. Keep out of children’s reach. Children and teenagers should not use this medicine for chickenpox or…

DOBUTREX® Lilly Dobutamine HCl Sympathomimetic Action And Clinical Pharmacology: Dobutamine is a direct acting inotropic agent whose primary activity results from stimulation of the b-receptors of the heart while producing less marked chronotropic, hypertensive, arrhythmogenic or vasodilatory effects. It does not cause the release of endogenous norepinephrine as does dopamine. No specific effect on the renal vasculature has been observed. In both animal and human studies, dobutamine produces less increase…

DOBUTAMINE HYDROCHLORIDE INJECTION Novopharm Inotropic Action And Clinical Pharmacology: Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the b-receptors of the heart while producing less marked chronotropic, hypertensive, arrhythmogenic or vasodilatory effects. Dobutamine, unlike dopamine, does not cause the release of endogenous norepinephrine. No specific effect on the renal vasculature was observed. Dobutamine produces less increase in heart rate and less decrease in peripheral vascular…

DITROPAN® Alza Canada Oxybutynin Chloride Anticholinergic – Antispasmodic Action And Clinical Pharmacology: Oxybutynin is a tertiary amine anticholinergic agent which exerts antimuscarinic as well as direct antispasmodic action on smooth muscle. In vitro studies have shown that its anticholinergic effects are weaker than those of atropine, but that it possesses greater antispasmodic activity. No blocking effects occur at skeletal neuromuscular junctions or in autonomic ganglia (e.g., no antinicotinic effects). In…

Diphtheria and Tetanus Toxoids Adsorbed and Pertussis Vaccine (DPT Adsorbed) Connaught Vaccine Action And Clinical Pharmacology: Immunization against diphtheria, tetanus, and pertussis has been associated with a striking decrease in the incidence of morbidity and mortality from these diseases. Simultaneous vaccination with a combination vaccine containing diphtheria and tetanus toxoids and pertussis vaccine have been used in Canada since 1958. Injection of bacterial proteins such as diphtheria and tetanus toxoids…

Diphtheria and Tetanus Toxoids Adsorbed and Poliomyelitis Vaccine (DT Polio Adsorbed) Connaught Vaccine Indications And Clinical Uses: For the primary immunization of infants and of children at or above the age of 2 months through 6 years of age (prior to the seventh birthday) against diphtheria, tetanus, and poliomyelitis in whom simultaneous immunization against pertussis is not indicated. DT Polio Adsorbed may be administered simultaneously with Hib conjugate vaccines and/or…