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DEPO-PROVERA® Pharmacia & Upjohn Medroxyprogesterone Acetate Progestogen Action And Clinical Pharmacology: Medroxyprogesterone acetate is a long-acting progestational steroid (progestogen) derived from a natural source (soybeans). Its long duration of action is a result of slow absorption from the injection site. Depo-Provera does not contain estrogen. For conception control, medroxyprogesterone inhibits the secretion of gonadotropins which, in turn, prevents follicular maturation and ovulation, and results in endometrial thinning. Additional progestational effects…

DEPO-TESTOSTERONE CYPIONATE Pharmacia & Upjohn Testosterone Cypionate Androgen Action And Clinical Pharmacology: Qualitatively similar to testosterone and its esters in physiologic activity, testosterone cypionate has the advantage of prolonged effect. In hypogonadal males, the effect of a single injection of 200 to 400 mg of testosterone cypionate, was observed to be maintained for 2 to 4 weeks, which is 2 to 4 times longer than the effect produced by a…

DENOREX® DENOREX® EXTRA STRENGTH Whitehall-Robins Coal Tar – Menthol – Chloroxylenol Antiseborrheic – Antipruritic Indications And Clinical Uses: Denorex: Relieves persistent dandruff flaking and itching. Denorex Extra Strength: Relieves persistent dandruff flaking, itching, psoriasis and seborrheic dermatitis. Precautions: Rinse thoroughly to avoid possible discoloration of light-colored hair. Do not use on wounds or abraded skin. Discontinue treatment if irritation develops. Avoid contact with eyes. For external use only. Dosage: Wet…

DEPEN® Carter Horner Penicillamine Chelating Agent Action And Clinical Pharmacology: As a chelating agent, penicillamine removes copper from the body. In vitro studies indicate that one atom of copper combines with 2 molecules of penicillamine. It would appear that 1 g of penicillamine should be followed by the excretion of about 200 mg of copper; however, the actual amount excreted is about 1% of this. Penicillamine also reduces excess cystine…

DEPAKENE® Abbott Valproic Acid Anticonvulsant Action And Clinical Pharmacology: Although valproic acid’s mechanism of action has not yet been established, the drug’s anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA). The effect on the neuronal membrane is unknown. Valproic acid is rapidly absorbed after oral administration. Peak serum levels occur approximately 1 to 4 hours after a single oral dose. The serum half-life of valproic…

Description Delsym is a cough suppressant that is used to treat cough caused by the common cold or flu. It has an advanced time-release formula. The medicine was invented in 1980s and was the first cough syrup brand to deliver 12 full hours of cough relief. Action And Clinical Pharmacology Dextromethorphan is a centrally acting antitussive which is comparable to codeine on a mg basis for cough suppression but lacking analgesic…

DELTASONE® Pharmacia & Upjohn Prednisone Corticosteroid Action And Clinical Pharmacology: Prednisone is a corticosteroid, which like other steroids, acts by controlling the rate of synthesis of proteins. The corticosteroids react with receptor proteins in the cytoplasm of sensitive cells to form a steroid-receptor complex. The steroid receptor complex moves into the nucleus where it binds to chromatin. Information carried by the steroid or more likely by the receptor protein directs…

DEMEROL® Sanofi Meperidine HCl Analgesic Action And Clinical Pharmacology: Meperidine is an opioid analgesic which acts predominantly as a mu-agonist. In its effects on the CNS, meperidine resembles but is not identical to morphine. Analgesic effects are detectable within about 15 minutes following oral administration, reaching a peak within about 2 hours and subsiding gradually over several hours thereafter. Onset of analgesic effect is faster (within 10 minutes) after s.c….

DEMADEX® Roche Torsemide Diuretic – Antihypertensive Action And Clinical Pharmacology: Mechanism of Action: Micropuncture studies in animals have shown that torsemide acts from within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the NaK2Clcarrier system. Clinical pharmacology studies have confirmed this site of action in humans, and effects in other segments of the nephron have not been demonstrated. Diuretic activity thus correlates better…

DECLOMYCIN® Wyeth-Ayerst Demeclocycline HCl Antibiotic Indications And Clinical Uses: Many strains of bacteria have been shown to be resistant to the tetracyclines. These include certain strains of streptococci, staphylococci, pneumococci, gonococci, and many other gram-negative organisms. Therefore, culture and sensitivity testing are advised to determine the susceptibility of the infecting organisms to tetracyclines. Chemotherapy should not be initiated until all the necessary bacteriological investigations have been started. Microorganisms that have…