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DIMENHYDRINATE INJECTION Astra Antiemetic Action And Clinical Pharmacology: While the precise mode of action of dimenhydrinate is not known, it has a depressant action on hyperstimulated labyrinthine functions or associated neural pathways. Indications: Prevention and relief of motion sickness and the nausea or vomiting incident to these conditions. The treatment or prophylaxis of the nausea and vomiting of radiation sickness, postoperative vomiting, and drug-induced nausea and vomiting; also for the…

DIMETANE® Whitehall-Robins Brompheniramine Maleate Antihistamine Indications And Clinical Uses: Prevention and symptomatic relief of manifestations of allergic states such as hay fever, conjunctivitis, angioneurotic edema, pruritus, rhinitis, atopic eczema, urticaria, dermatitis, drug reaction, rhus dermatitis, insect and spider bites. Contra-Indications: Hypersensitivity to antihistamines and patients receiving MAO inhibitors. Precautions: Occupational Hazards: Patients should be cautioned not to operate vehicles or hazardous machinery until their response to the drug has been…

DIMETANE® EXPECTORANT Whitehall-Robins Brompheniramine Maleate – Guaifenesin – Phenylephrine HCl – Phenylpropanolamine HCl Antihistamine – Expectorant – Decongestant Indications And Clinical Uses: For the temporary relief of coughing and the complications of allergy states, including perennial and seasonal allergic rhinitis. In addition, indicated for the symptomatic relief of cough, nasal congestion and runny nose accompanying the common cold and other respiratory tract infections. Contra-Indications: Hypersensitivity to any of the components;…

DIMETANE® EXPECTORANT-C DIMETANE® EXPECTORANT-DC Whitehall-Robins Brompheniramine Maleate – Phenylephrine HCl – Phenylpropanolamine HCl – Guaifenesin – Codeine Phosphate Brompheniramine Maleate – Phenylephrine HCl – Phenylpropanolamine HCl – Guaifenesin – Hydrocodone Bitartrate Antihistamine – Decongestant – Expectorant – Antitussive Indications And Clinical Uses: The temporary relief of coughing and the complications of allergic states including manifestations such as perennial and seasonal allergic rhinitis. The symptomatic relief of cough, nasal stuffiness and…

DILTIAZEM HYDROCHLORIDE INJECTION Novopharm Antiarrhythmic Action And Clinical Pharmacology: Diltiazem inhibits the influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle. The therapeutic benefits of diltiazem in supraventricular tachycardias are related to its ability to slow atrioventricular (AV) nodal conduction time and prolong AV nodal refractoriness. Diltiazem exhibits frequency (use) dependent effects on AV nodal conduction such that it may selectively reduce the heart rate during…

DIHYDROERGOTAMINE (DHE) Novartis Pharmaceuticals Dihydroergotamine Mesylate Vascular Headache Therapy Action And Clinical Pharmacology: Dihydroergotamine displays moderate to high affinity for various serotonergic receptor subtypes (5-HT1A, 5-HT1C, 5-HT1D, 5-HT2). The compound exerts agonistic activity at the 5-HT1D subtype and antagonistic activity at the 5-HT2 subtype. Dihydroergotamine also displays blocking actions at alpha adrenergic receptor level, with a direct stimulating effect on the smooth muscle of peripheral blood vessels. Its tonic effect…

DILANTIN® INFATABS DILANTIN®-30 PEDIATRIC DILANTIN®-125 Parke-Davis Phenytoin Anticonvulsant Action And Clinical Pharmacology: Dilantin Infatabs and Dilantin-30 Pediatric/Dilantin-125 suspensions are anticonvulsant drugs which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes…

DIFFERIN® Galderma Adapalene Acne Therapy Action And Clinical Pharmacology: Adapalene is a chemically stable, retinoid-like compound. Biochemical and pharmacological profile studies have demonstrated that adapalene is a potent modulator of cellular differentiation, keratinization and inflammatory processes all of which represent important features in the pathology of acne vulgaris. Although the exact mode of action of adapalene is unknown, current evidence suggests that topical adapalene normalizes the differentiation of follicular epithelial…

DICLECTIN® Duchesnay Doxylamine Succinate – Pyridoxine HCl Antinauseant against Nausea and Vomiting of Pregnancy Action And Clinical Pharmacology: The action of Diclectin is due to 2 unrelated compounds. Doxylamine succinate, an antihistamine, provides the antinauseant and antiemetic activity; pyridoxine HCl provides a supplement of vitamin B6 to prevent a possible pyridoxine deficiency during pregnancy. Also, studies have shown that pyridoxine itself could have an antinauseant activity. The onset of the…

DIAMICRON® Servier Gliclazide Oral Hypoglycemic Action And Clinical Pharmacology: Gliclazide is an hypoglycemic agent of the sulfonylurea group. Its hypoglycemic action is related to an improvement in insulin secretion from the functioning beta cells of the pancreas. It potentiates the insulin release and improves the dynamics of insulin. Hemobiological properties of gliclazide have been observed in pharmacology studies. These are attributed to gliclazide action on the platelet behavior, prostaglandin equilibrium…