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DALACIN® C PHOSPHATE STERILE SOLUTION Pharmacia & Upjohn Clindamycin Phosphate Antibiotic Action And Clinical Pharmacology: Following parenteral administration, biologically inactive clindamycin phosphate is rapidly hydrolyzed in plasma to active clindamycin. Clindamycin exerts its antibacterial effect by binding to the 50 S ribosomal subunit of susceptible bacteria, causing a reduction in the rate of synthesis of nucleic acid, and cessation of protein synthesis. Clindamycin is primarily bacteriostatic, but may be bactericidal…

DALACIN® VAGINAL CREAM Pharmacia & Upjohn Clindamycin Phosphate Antibacterial Action And Clinical Pharmacology: Although clindamycin phosphate is inactive in vitro, in vivo hydrolysis converts this compound to the antibacterially-active clindamycin. Clindamycin inhibits bacterial protein synthesis by its action at the bacterial ribosome. The antibiotic preferentially binds to the 50S ribosomal subunit, and affects the process of peptide chain initiation. Clindamycin may inhibit the binding of aminoacyl-tRNA or inhibit the translocation…

DYAZIDE® SmithKline Beecham Triamterene – Hydrochlorothiazide Diuretic – Antihypertensive Action And Clinical Pharmacology: Dyazide is a combination of 2 diuretics with different but complementary modes of action. Diuretic activity following a single dose is evident within the first hour, reaches a peak at 2 to 3 hours, and tapers off during the subsequent 7 to 9 hours. Because of the potassium-conserving effect of its triamterene component, Dyazide reduces the risk…

DTIC® Bayer Dacarbazine Antineoplastic Agent Action And Clinical Pharmacology: Although dacarbazine’s exact mechanism of action is not known, 3 hypotheses have been offered: 1. inhibition of DNA synthesis by acting as a purine analog. 2. action as an alkylating agent. 3. interaction with SH groups. Dacarbazine is only slightly (approximately 5%) protein bound. Its plasma half-life after i.v. administration is approximately 35 minutes. In animals, approximately 46% of a radio…

CORICIDIN “D”® Schering Chlorpheniramine Maleate – Phenylpropanolamine Compound Antihistaminic – Decongestant – Antipyretic – Analgesic Indications And Clinical Uses: Coricidin “D”: Symptomatic relief of nasal congestion and other discomforts associated with sinusitis, colds and allergic or vasomotor rhinitis. Coricidin “D” Long Acting: For up to 12-hour relief of congestion and sneezing due to colds. Contra-Indications: Sensitivity to any of the components, patients receiving MAO inhibitors in the preceding 3 weeks….

CORICIDIN® NON-DROWSY Schering ASA – Phenylpropanolamine Analgesic – Antipyretic – Decongestant Indications And Clinical Uses: Symptomatic relief of sinus pain and congestion. Contra-Indications: Sensitivity to any of the components, patients receiving MAO inhibitors in the preceding 3 weeks. Precautions: Although phenylpropanolamine causes practically no pressor effect in normotensive individuals, it should be used with caution in patients with hypertension, diabetes, chronic lung disease, latent or clinically recognized angle closure glaucoma,…

COREG™ SmithKline Beecham Carvedilol Congestive Heart Failure Agent Action And Clinical Pharmacology: Carvedilol is a cardiovascular agent for the treatment of CHF that combines beta-adrenoceptor blockade and vasodilation in a single racemic mixture. Nonselective beta-adrenoceptor blocking activity is present in the S(-) enantiomer and alpha 1-adrenoceptor blocking activity is present at equal potency in both the R(+) and S(-) enantiomers. Carvedilol has no intrinsic sympathomimetic activity. Its action on beta-receptors…

  CORGARD® Squibb Nadolol Antianginal – Antihypertensive Agent Action And Clinical Pharmacology: Nadolol is a noncardioselective beta-adrenergic blocking agent. It does not possess membrane stabilizing or intrinsic sympathomimetic (partial agonist) activities. The exact mechanism by which the drug exercises its anti-anginal effect is not certain. An important factor may be the reduction of myocardial oxygen requirements by blocking catecholamine-induced increases in heart rate, systolic blood pressure and the velocity and…

CORICIDIN® Cold Tablets Schering Chlorpheniramine – ASA Compound Antihistaminic – Antipyretic – Analgesic Indications And Clinical Uses: For relief of cold and flu symptoms, fever, aches and pains, accompanying a cold, relief of simple headache. Contra-Indications: Sensitivity to any of the components. Precautions: Since the depressant effects of antihistamines are additive to those of other drugs affecting the CNS, patients should be cautioned against drinking alcoholic beverages or taking hypnotics,…

COPHYLAC® Hoechst Marion Roussel Normethadone – p-Hydroxyephedrine HCl Compound Antitussive Indications And Clinical Uses: The treatment of cough associated with inflamed mucosa, which does not respond to products of lesser potency. Cophylac Expectorant is indicated to facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum which does not respond to products of lesser potency. Contra-Indications: Do not administer to patients receiving MAO inhibitors. Cophylac Expectorant is contraindicated…