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HALFAN™ SmithKline Beecham Halofantrine HCl Antimalarial Action And Clinical Pharmacology: Halofantrine is schizonticidal and exerts its action at the erythrocytic stage of the life cycle (trophozoite and schizont). It is not effective against exo-erythrocytic (hepatic) schizonts or against the sporozoite, merozoite or gametozoite stages of the life cycle of Plasmodium species investigated. The precise mechanism of action of halofantrine is not certain. It has been hypothesized that halofantrine interferes with…

HAVRIX™ SmithKline Beecham Hepatitis A Vaccine (Inactivated) Active Immunization Agent against infection by Hepatitis A virus Action And Clinical Pharmacology: Hepatitis A vaccine (inactivated) confers immunity against hepatitis A virus (HAV) infection by inducing the production of specific anti-HAV antibodies. In clinical studies involving subjects of 18 to 50 years of age, specific humoral antibodies against HAV were detected in more than 88% of vaccinees at day 15 and 99%…

HABITROL® Novartis Consumer Health Nicotine Smoking Cessation Aid Action And Clinical Pharmacology: Habitrol delivers S(-)-nicotine, the active component of tobacco smoke, transdermally into the systemic circulation, continuously over 24 hours. Habitrol releases S(-)-nicotine in controlled amounts at a rate sufficient to produce plasma nicotine concentrations comparable to trough levels observed in smokers before smoking a cigarette. Because of the low, continuous delivery of S(-)-nicotine through the skin, Habitrol does not…

HALCION® Pharmacia & Upjohn Triazolam Hypnotic Action And Clinical Pharmacology: Triazolam is a benzodiazepine hypnotic with a very short elimination half-life (about 3 hours). In sleep laboratory studies of 1 to 21 days duration, triazolam significantly decreased sleep latency, increased duration of sleep and decreased the number of nocturnal awakenings. However, after 2 weeks of consecutive nightly administration, the drug’s effect on total wake time was decreased, and the values…

HALDOL® LA Janssen-Ortho Haloperidol Decanoate Antipsychotic Action And Clinical Pharmacology: Haloperidol decanoate, an ester derivative of haloperidol obtained from condensation of haloperidol with decanoic acid possesses the antipsychotic properties of haloperidol. When it is administered as an i.m. depot in sesame oil, esterases present in blood and tissues hydrolyze haloperidol decanoate to provide a slow release of the active neuroleptic haloperidol from the depot into the systemic circulation. The onset…

HALDOL® Janssen-Ortho Haloperidol Antipsychotic Action And Clinical Pharmacology: Haloperidol is a butyrophenone derivative with antipsychotic properties that has been considered particularly effective in the management of hyperactivity, agitation, and mania. Haloperidol is an effective neuroleptic and also possesses antiemetic properties; it has a marked tendency to provoke extrapyramidal effects and has relatively weak alpha-adrenolytic properties. It may also exhibit hypothermic and anorexiant effects and potentiate the action of barbiturates, general…

GRAVOL® Preparations Carter Horner Dimenhydrinate Antiemetic – Antivertigo Indications And Clinical Uses: Prevention or relief of motion sickness, radiation sickness, postoperative vomiting, and drug induced nausea and vomiting; it has also been used for the symptomatic relief of nausea and vertigo due to Meniere’s disease and other labyrinthine disturbances. Contra-Indications: Glaucoma, chronic lung disease, difficulty in urination due to prostatic hypertrophy. Manufacturers’ Warnings In Clinical States: As dimenhydrinate has a…

GLYSENNID® Novartis Consumer Health Sennosides Laxative Action And Clinical Pharmacology: Glysennid is a laxative which selectively stimulates the colon 8 to 12 hours after ingestion. Therefore, if Glysennid is taken before retiring, sleep is usually not disturbed. Indications And Clinical Uses: Atonic constipation (e.g., in the elderly, after surgery, in the puerperium or due to neurological disorders). Contra-Indications: Known hypersensitivity to sennosides or any of the ingredients; appendicitis, intestinal hemorrhage,…

GONAL-F® Serono Follitropin alpha (rDNA origin) Gonadotropin Action And Clinical Pharmacology: Gonal-F is a gonadotropin preparation of recombinant DNA origin. The active ingredient, recombinant human follicle stimulating hormone (r-hFSH), is a human glycoprotein hormone which consists of 2 noncovalently linked, nonidentical protein components designated as the a- and b-subunits. The physicochemical, immunological, and biological activities of r-hFSH are similar to those of human menopausal urine-derived hFSH, but free of urinary…

GOOD START® Nestle, Carnation Infant Formula Indications And Clinical Uses: A nutritionally complete iron fortified infant formula for routine feeding of infants from birth if breast-feeding is not an option or if a supplement is required. Good Start has the added benefit of being easier to tolerate than routine cow’s milk or soy based formula because the protein has been partially broken down to reduce the possibility of an allergic…