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HYDROPRES®-25 MSD Hydrochlorothiazide – Reserpine Diuretic – Antihypertensive Indications And Clinical Uses: Fixed-dose combination drugs are not indicated for initial therapy. Patients should be titrated on the individual drugs. If the fixed combination represents the dosage so determined, its use may be more convenient in patient management. If during maintenance therapy dosage adjustment is necessary it is advisable to use the individual drugs. In many cases of hypertension, Hydropres-25 alone…

HYDROMORPH CONTIN® Purdue Frederick Hydromorphone HCl Opioid Analgesic Action And Clinical Pharmacology: Hydromorphone, a semi-synthetic opioid agonist, is a hydrogenated ketone of morphine and shares the pharmacologic properties typical of opioid analgesics. Hydromorphone and related opioids produce their major effects on the CNS and gastrointestinal tract. These include analgesia, drowsiness, mental clouding, changes in mood, euphoria or dysphoria, respiratory depression, cough suppression, decreased gastrointestinal motility, nausea, vomiting, increased cerebrospinal fluid…

HYGROTON® Novartis Pharmaceuticals Chlorthalidone Diuretic – Antihypertensive Action And Clinical Pharmacology: Chlorthalidone inhibits reabsorption of sodium and chloride in the distal renal tubule thus promoting water loss. The higher urine volume increases potassium loss. Little information is available on the absorption of the drug. Its long elimination half-life and clinical experience place it as a long-acting thiazide derivative. This may not be important clinically because the biological effects of thiazides…

HYDROCHLOROTHIAZIDE General Monograph, Diuretic – Antihypertensive Pharmacology: Hydrochlorothiazide inhibits reabsorption of sodium and chloride in the distal tubule thus promoting water loss. The higher urine volume increases potassium loss; this loss can often be decreased by restricting sodium intake. Oral doses are well absorbed and reach peak effect in about 4 hours, with a 6 to 12 hour duration. It is excreted unchanged in the urine with a half-life of…

HYCOMINE® HYCOMINE®-S DuPont Pharma Hydrocodone Compound Antitussive – Antihistaminic – Decongestant Action And Clinical Pharmacology: See Hycodan for pharmacology of hydrocodone. Pyrilamine maleate is a competitive H1-receptor histamine-blocking drug, thereby counteracting the effects of histamine release associated with allergic manifestations of upper respiratory tract inflammatory disorders. H1-blocking drugs inhibit the actions of histamine on smooth muscle, capillary permeability, and can both stimulate and depress the CNS. Phenylephrine HCl effects its…

HYDERGINE® Novartis Ergoloid Mesylates Adjunctive Management of Idiopathic Dementia Action And Clinical Pharmacology: The possible mechanism of action of ergoloid mesylates has not been determined. There is no evidence that ergoloid mesylates affect cerebrovascular insufficiency or cerebral arteriosclerosis. Ergoloid mesylates do not have the vasoconstrictor effects of the natural ergot alkaloids. Indications And Clinical Uses: May be of some value in the adjunctive management of selective symptoms of elderly patients…

HYDRASENSE® NASAL CARE Schering Sea Water Nasal Cleanser Indications And Clinical Uses: Cleanses and relieves excessive mucus accumulation by clearing nasal cavities congested by colds, allergies, sinusitis and rhinitis. It is a simple and effective solution to relieve dry nasal conditions commonly associated with heating or air conditioning systems in homes or airplanes. Precautions: Safe for infants, Hydrasense Baby Mist can be used with confidence without fear of harming delicate,…

HYCAMTIN™ SmithKline Beecham Topotecan HCl Antineoplastic Action And Clinical Pharmacology: Topotecan inhibits topoisomerase-I, an enzyme that functions in DNA replication to relieve the torsional strain introduced ahead of the moving replication fork. Topotecan inhibits topoisomerase-I by stabilizing the covalent complex of enzyme and strand-cleaved DNA which is an intermediate of the catalytic mechanism, thereby inducing breaks in the protein-associated DNA single-strands, resulting in cell death. Pharmacokinetics: Following i.v. administration of…

HYCODAN® DuPont Pharma Hydrocodone Bitartrate Antitussive Action And Clinical Pharmacology: Clinical trials have proven hydrocodone bitartrate to be an effective antitussive agent which is pharmacologically 2 to 8 times as potent as codeine. At equi-effective doses, its sedative action is greater than that of codeine. The precise mechanisms of action of hydrocodone and other opiates are not known; however, hydrocodone is believed to act by directly depressing the cough centre….

HONVOL® Carter Horner Diethylstilbestrol Diphosphate Prostatic Carcinoma Therapy Indications And Clinical Uses: For intensive and selective palliative therapy of inoperable prostatic carcinoma. Contra-Indications: Patients with active hepatic dysfunction or disease, especially of the obstructive type; a personal history of breast cancer, except in special circumstances; a history of cerebrovascular accident, coronary thrombosis or the presence of classical migraine; a history of thrombophlebitis or thromboembolic disease; partial or complete loss of…