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LIVOSTIN™ EYE DROPS CIBA Vision Levocabastine HCl Histamine H1-antagonist Action And Clinical Pharmacology: Levocabastine is a potent, fast-acting and highly selective histamine H1-antagonist with a sustained duration of action. Within 10 to 15 minutes of topical application to the eyes, levocabastine inhibits: itching, redness and chemosis induced by conjunctival provocation with histamine; itching, redness, chemosis, eyelid swelling, and tearing induced by conjunctival provocation with allergens; and itching and redness induced…

LIPIDIL MICRO® Fournier Fenofibrate (Micronized) Lipid Metabolism Regulator Action And Clinical Pharmacology: Fenofibrate lowers elevated serum lipids by decreasing the low density lipoprotein (LDL) fraction rich in cholesterol and the very low density lipoprotein (VLDL) fraction rich in triglycerides. In addition, fenofibrate increases the high density lipoprotein (HDL) cholesterol fraction. Fenofibrate appears to have a greater depressant effect on the very low density lipoproteins (VLDL) than on the low density…

LIPISORB® Mead Johnson Therapeutic Nutrient Indications And Clinical Uses: A nutritionally complete liquid diet specifically designed for patients with fat malabsorption (e.g., inflammatory bowel disease, cystic fibrosis, short bowel syndrome and HIV infection). It provides complete vitamins and minerals with a readily absorbed fat blend. This vanilla flavored beverage can be fed orally or as a tube feeding. tag_DosageDosage Dosage And Administration: As prescribed by a physician. Tube feeding may…

LINCOCIN® Pharmacia & Upjohn Lincomycin HCl Monohydrate Antibiotic Action And Clinical Pharmacology: The mode of action of lincomycin is the inhibition of protein synthesis by the inhibition of the binding of aminoacyl sRNA to the messenger ribosome complex at the 50S ribosomal unit. Lincomycin is absorbed rapidly after oral administration, reaching peak levels in 2 to 4 hours. Levels above the minimum inhibitory concentration for most gram-positive organisms are maintained…

LIORESAL® Novartis Pharmaceuticals Baclofen Muscle Relaxant – Antispastic Action And Clinical Pharmacology: Baclofen’s precise mechanisms of action are not fully known. It inhibits both monosynaptic and polysynaptic reflexes at the spinal level, probably by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect. Although baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence…

LIORESAL® Intrathecal Novartis Pharmaceuticals Baclofen Muscle Relaxant – Antispastic Action And Clinical Pharmacology: The precise mechanisms of action of baclofen as a muscle relaxant and antispastic agent are not fully understood. Baclofen inhibits both monosynaptic and polysynaptic reflex transmission at the spinal level, possibly by decreasing excitatory neurotransmitter release from primary afferent terminals. Actions at supraspinal sites may also contribute to its clinical effect. Baclofen is an analogue of the…

LEVOPHED® Sanofi Norepinephrine Bitartrate Sympathomimetic Action And Clinical Pharmacology: Norepinephrine functions as a powerful peripheral vasoconstrictor (alpha-adrenergic action) and as a potent inotropic stimulator of the heart and dilator of coronary arteries (beta-adrenergic action). Both of these actions result in an increase in systemic blood pressure and coronary artery blood flow. Cardiac output will vary reflexly in response to systemic hypertension but is usually increased in hypotensive man when the…

LEVOVIST® Berlex Canada Galactose – Palmitic Acid Ultrasound Contrast Agent Action And Clinical Pharmacology: Levovist is an ultrasound contrast agent consisting of granules which are composed of 99.9% galactose and 0.1% palmitic acid. Prior to use, Levovist must be reconstituted with sterilized water for injections and shaken vigorously by hand for 5 to 10 seconds. After injection of the suspension into a peripheral vein, Levovist leads to temporarily enhanced ultrasound…

LECTOPAM® Roche Bromazepam Anxiolytic – Sedative Action And Clinical Pharmacology: Bromazepam is a benzodiazepine with anxiolytic and sedative properties which are of value in the symptomatic relief of pathological anxiety in psychoneurotic patients. The absolute bioavailability of unchanged, orally administered bromazepam is 60%, and peak blood levels are achieved within 2 hours after administration. On average, 70% of bromazepam is bound to plasma proteins. Bromazepam is metabolized in the liver,…

exoLERITINE® Injection LERITINE® Tablets Frosst Anileridine Phosphate Anileridine HCl Opioid Analgesic Action And Clinical Pharmacology: Anileridine, a synthetic opioid, is a strong analgesic. The chief pharmacologic action is exerted on the CNS. The analgesic effects usually are prompt in onset either orally or parenterally (approximately within 15 minutes). Duration of action is about 2 or 3 hours. Respiratory depression, when it occurs, is of shorter duration than that seen with…