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NAPROSYN® Roche Naproxen Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Naproxen has demonstrated anti-inflammatory, analgesic and antipyretic properties in classical animal test systems. In patients with rheumatoid arthritis, the anti-inflammatory action has been shown by a reduction in joint swelling, pain, and duration of morning stiffness, and by enhanced grip strength and increased mobility. It exhibits an anti-inflammatory effect even in adrenalectomized animals, and therefore its action is not mediated…

NADOSTINE® Preparations Nadeau Nystatin Antifungal – Antibiotic Indications And Clinical Uses: Oral Suspension: Prevention and treatment of candidal infections of the mouth (thrush) and intestinal candidiasis in infants and children. Oral Tablets: Prevention and treatment of oral, esophageal and intestinal candidiasis. Protection against candidal overgrowth during antibiotic and/or corticosteroid therapy. Topical Products: Treatment of mucocutaneous candidiasis. The cream is usually used to treat intertriginous areas. Vaginal Products: Local treatment of…

MSD® ENTERIC COATED ASA Johnson & Johnson Merck ASA Nonsteroidal Anti-inflammatory – Analgesic – Platelet Aggregation Inhibitor Action And Clinical Pharmacology: ASA has analgesic, antipyretic and anti-inflammatory properties. In rheumatic diseases, although the analgesic and antipyretic effects are useful, the major purpose for which ASA is used is to reduce the intensity of the inflammatory process. Inhibition of prostaglandin synthesis may be involved in the anti-inflammatory action of ASA. ASA…

MS•IR® Purdue Frederick Morphine Sulfate Opioid Analgesic Action And Clinical Pharmacology: Morphine is an opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, morphine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of the…

MS CONTIN® Purdue Frederick Morphine Sulfate Opioid Analgesic Action And Clinical Pharmacology: Morphine is an opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, morphine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of…

MONISTAT® 7 Cream MONISTAT 7 Vaginal Suppositories MONISTAT® 7 DUAL-PAK® Package (Also known as Combination Packs) MONISTAT® DERM Cream MONISTAT® 3 DUAL-PAK® Package (Also known as Combination Packs) MONISTAT® 3 Vaginal Ovules McNeil Consumer Products Miconazole Nitrate Antifungal Action And Clinical Pharmacology: Depending upon concentration, miconazole exhibits broad spectrum in vitro fungistatic or fungicidal activity against species of the genus Candida. Miconazole also inhibits several other genera of fungi, including…

MOGADON® Roche Nitrazepam Hypnotic – Anticonvulsant Action And Clinical Pharmacology: Nitrazepam is a benzodiazepine with hypnotic and anticonvulsant properties. In sleep laboratory studies, nitrazepam decreased sleep latency, increased total sleep time and decreased awake time. There is delay in the onset, and decrease in the duration of REM sleep. Nitrazepam is reported to significantly decrease stage 1, 3 and 4 sleep and to increase stage 2. Following discontinuation of the…

MOBIFLEX® Roche Tenoxicam Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Tenoxicam is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. Its mechanism of action, as with other nonsteroidal anti-inflammatory agents, is not yet completely known. Tenoxicam is an inhibitor of prostaglandin biosynthesis both in vitro and in vivo (protects mice against arachidonic acid induced toxicity). In vitro tests of leukocyte peroxidase also suggest that tenoxicam may act as a…

MIRAPEX® Boehringer Ingelheim Pramipexole Dihydrochloride Antiparkinsonian Agent – Dopamine Agonist Action And Clinical Pharmacology: Pramipexole is a non ergot dopamine agonist with high in vitro specificity at the D2 subfamily of dopamine receptors. Pramipexole is a full agonist and exhibits higher affinity to the D3 receptor subtypes (which are in prominent distribution within the mesolimbic area) than to D2 or D4 receptor subtypes. While pramipexole exhibits high affinity for the…

MINIPRESS™ Pfizer Prazosin HCl Antihypertensive Action And Clinical Pharmacology: Prazosin causes a decrease in total peripheral resistance. Animal studies suggest that the vasodilator effect of prazosin is related to selective blockade of post-synaptic alpha1-adrenoceptors. The results of dog forelimb experiments demonstrate that the peripheral vasodilator effect is confined mainly to the level of the resistance vessels (arterioles). Hemodynamic studies have been carried out in man following acute single dose administration…