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PHENYTOIN General Monograph, Diphenylhydantoin Anticonvulsant Action And Clinical Pharmacology: Phenytoin is an anticonvulsant which elevates the seizure threshold in the motor cortex by limiting the post-tetanic potentiation (PTP) of synaptic transmission. It exerts this effect by preventing the excessive accumulation of intracellular sodium during tetanic stimulation by either reducing the passive influx of sodium or increasing the efficiency of the sodium pump. By limiting PTP, phenytoin prevents the spread of…

PETHIDINE INJECTION BP Faulding Meperidine HCl Opioid Analgesic Action And Clinical Pharmacology: Meperidine is a narcotic analgesic with multiple actions qualitatively similar to those of morphine. The most prominent of these actions involve the CNS and organs which are composed of smooth muscle. Analgesia and sedation are the principal actions of therapeutic value. Some evidence suggests that meperidine may produce less smooth muscle spasm, constipation, and depression of the cough…

PHAZYME™ Preparations R & C Simethicone Antiflatulent Indications And Clinical Uses: For relief of discomfort due to gastrointestinal gas, resulting from aerophagia, dyspepsia. Also, for relief of gas distress associated with other functional or organic conditions such as: diverticulosis, spastic colon, hyperacidity, postcholecystectomy syndrome, chronic cholecystitis, chronic pancreatitis, chronic alcoholism, elevated diaphragm in late pregnancy, aerophagia and aerophagic pseudoangina. Dosage And Administration: Phazyme-95: 1 softgel before meals and at bedtime….

PERIACTIN® Johnson & Johnson Merck Cyproheptadine HCl Antihistaminic Action And Clinical Pharmacology: Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects recommended for the symptomatic treatment of allergic disorders and pruritic dermatoses, as well as certain types of vascular headaches. Indications And Clinical Uses: Cyproheptadine has a wide range of antiallergic and antipruritic activity and can be used successfully in the treatment of acute and chronic allergies…

PERMAX® Draxis Health Pergolide Mesylate Dopamine Agonist Action And Clinical Pharmacology: Pergolide mesylate, a synthetic ergot derivative, is a dopamine receptor agonist at both D1 and D2 receptor sites. In Parkinson’s disease, pergolide is believed to exert its therapeutic effect by directly stimulating postsynaptic dopamine receptors in the corpus striatum. In addition, pergolide suppresses the secretion of prolactin, causes a transient increase in serum concentration of growth hormone and a…

PEPTOL® Carter Horner Cimetidine Histamine H2 Receptor Antagonist Action And Clinical Pharmacology: Cimetidine inhibits competitively the action of histamine at the histamine H2 receptor and it is not an anticholinergic agent. It inhibits both daytime and nocturnal basal gastric acid secretion. Similarly, gastric acid secretion stimulated by food, histamine, pentagastrin, insulin and caffeine is inhibited by cimetidine. After oral administration, cimetidine is absorbed rapidly. The plasma half-life is about 2…

PERCOCET® PERCOCET®-DEMI DuPont Pharma Oxycodone HCl – Acetaminophen Opioid Analgesic Action And Clinical Pharmacology: The principal ingredient, oxycodone, is a semisynthetic opioid analgesic with multiple actions qualitatively similar to those of morphine; the most prominent of these involve the CNS and organs composed of smooth muscle. The principal actions of therapeutic value of the oxycodone in Percocet are analgesia and sedation. Oxycodone is similar to codeine and methadone in that…

PERGONAL® Serono Menotropins Gonadotropins Action And Clinical Pharmacology: Menotropins is a purified preparation of gonadotropins extracted from the urine of postmenopausal women. Indications And Clinical Uses: Women: Menotropins and human chorionic gonadotropin (hCG) given in a sequential manner are indicated for the induction of ovulation and to enable pregnancy in the anovulatory infertile patient, in whom the cause of anovulation is functional and is not due to primary ovarian failure….

PERCODAN® PERCODAN®-DEMI DuPont Pharma Oxycodone HCl – ASA Opioid Analgesic Action And Clinical Pharmacology: The principal ingredient, oxycodone, is a semisynthetic opioid analgesic with multiple actions qualitatively similar to those of morphine; the most prominent of these involve the CNS and organs composed of smooth muscle. The principal actions of therapeutic value of the oxycodone in Percodan are analgesia and sedation. Oxycodone is similar to codeine and methadone in that…

PENTASPAN® DuPont Pharma Pentastarch Plasma Volume Expander Action And Clinical Pharmacology: The colloidal properties of pentastarch render it useful as a plasma volume expander. I.V. infusion of pentastarch results in expansion of the plasma volume in excess of the volume infused. This expansion persists for approximately 18 to 24 hours and is expected to improve the hemodynamic status for 12 to 18 hours. Pentastarch molecules below 50 000 molecular weight…