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PONDOCILLIN® Leo Pivampicillin Antibiotic Action And Clinical Pharmacology: Pivampicillin is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin. It is an inactive pro-drug, which is converted during its absorption from the gastrointestinal tract to the microbiologically active ampicillin, together with formaldehyde and pivalic acid, by non-specific esterases present in most body tissues. Amounts in excess of 99% of the pivampicillin absorbed are converted to ampicillin within 15 minutes of absorption….

POLLINEX®-R Bencard Modified Ragweed Tyrosine Adsorbate Vaccine Action And Clinical Pharmacology: Pollinex-R is an aqueous extract of short ragweed pollen (Ambrosia elatior) chemically modified with gluteraldehyde adsorbed onto tyrosine and then suspended in saline. The exact mode of therapeutic action of Pollinex-R, as with other allergy vaccines, is unknown. It has been proposed the elevation of IgG blocking antibodies may interfere with the immediate hypersensitivity reaction of patients exposed to…

POLOCAINE® 3% POLOCAINE® 2% with LEVONORDEFRIN 1:20 000 Astra Mepivacaine HCl Mepivacaine HCl – Levonordefrin Local Anesthetic Action And Clinical Pharmacology: Mechanism of Action: Mepivacaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Local anesthetics of the amide type are thought to act within sodium channels of the nerve membrane. Onset of Action: Mepivacaine has a…

PLATINOL®-AQ Bristol Cisplatin Antineoplastic Caution: Cisplatin is a potent drug and should be used only by physicians experienced with cancer chemotherapeutic drugs (see Warnings and Precautions). Blood counts as well as renal and hepatic function tests should be taken regularly. Discontinue the drug if abnormal depression of bone marrow or abnormal renal or hepatic function is seen. Action And Clinical Pharmacology: Cisplatin has biochemical properties similar to those of bifunctional…

PLENDIL® Astra Felodipine Antihypertensive Agent Action And Clinical Pharmacology: Felodipine is a calcium ion influx inhibitor (calcium channel blocker). Felodipine is a member of the dihydropyridine class of calcium channel blockers. Mechanism of Action: The therapeutic effect of this group of drugs is believed to be related to their specific cellular action of selectively inhibiting transmembrane influx of calcium ions into cardiac muscle and vascular smooth muscle. The contractile processes…

PHYLLOCONTIN® PHYLLOCONTIN®-350 Purdue Frederick Aminophylline Bronchodilator Action And Clinical Pharmacology: Aminophylline is the ethylenediamine salt of theophylline. The pharmacodynamics of Phyllocontin and Phyllocontin-350 tablets are a function of theophylline blood levels. Theophylline is a xanthine structurally related to theobromine and caffeine. As with other xanthine derivatives, the precise mechanism of action of theophylline has not been determined. Theophylline stimulates the CNS and skeletal muscles, stimulates cardiac muscle, relaxes certain smooth…

PIPORTIL L4® Rh´ne-Poulenc Rorer Pipotiazine Palmitate Antipsychotic Action And Clinical Pharmacology: Pipotiazine palmitate is the palmitic ester of pipotiazine, a piperidine phenothiazine with antipsychotic properties and weak sedative activity with prolonged duration of action. The onset of action appears usually within the first 2 to 3 days after injection and the effects of the drug on psychotic symptoms are significant within 1 week. Improvement in symptomatology lasts from 3 to…

pHisoHex® Sanofi Hexachlorophene Antibacterial – Skin Cleanser Description: pHisoHex is an antibacterial sudsing emulsion. It contains entsufon (sodium octylphenoxyethoxyethyl ether sulfonate), lanolin cholesterols, petrolatum and 3% hexachlorophene on a total weight basis. It is a colloidal dispersion of the active ingredients in a stable emulsion. Entsufon is a synthetic detergent which is effective in many kinds of water – hard or soft, cold or hot – and under acid as…

PHENERGAN® Preparations Novartis Consumer Health Promethazine HCl Antihistamine Action And Clinical Pharmacology: Promethazine is an antihistamine with sedative, antiemetic and antispasmodic properties. In addition, it exerts local anesthetic effects and potentiates analgesics, anesthetics and other CNS depressants. Indications And Clinical Uses: Allergic reactions: hay fever, urticaria, vasomotor rhinitis, skin allergies, poison ivy, insect bites; for the relief of pruritus due to various dermatologic conditions. Nausea and vomiting of various etiologies:…

PHENERGAN® Injectable Rhône-Poulenc Rorer Promethazine HCl Antihistamine Action And Clinical Pharmacology: Promethazine is an antihistamine with sedative, antiemetic and antispasmodic properties. In addition, it exerts local anesthetic effects and potentiates analgesics, anesthetics and other CNS depressants. Indications And Clinical Uses: Allergic reactions: hay fever, urticaria, vasomotor rhinitis, skin allergies, poison ivy, insect bites; for the relief of pruritus due to various dermatologic conditions. Nausea and vomiting of various etiologies: motion…