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LIDEX® Medicis Fluocinonide Topical Corticosteroid Indications And Clinical Uses: For topical therapy of corticosteroid-responsive acute and chronic skin eruptions where an anti-inflammatory, anti-allergenic and antipruritic activity in the topical management is required. Contra-Indications: Untreated bacterial, tubercular, fungal and most viral lesions of the skin (including herpes simplex, vaccinia and varicella). Contraindicated in individuals with a history of hypersensitivity to any of the components. Manufacturers’ Warnings In Clinical States: Pregnancy and…

LEVOTEC Technilab Levothyroxine Sodium Hypothyroidism Therapy Action And Clinical Pharmacology: Levothyroxine sodium is the monosodium salt of the levorotatory isomer of thyroxin (tetraiodothyronine), the principal hormone secreted by the normal thyroid gland. Following oral administration, the absorption of levothyroxine is incomplete and variable (50 to 75%), especially when taken with food. Once absorbed, synthetic levothyroxine is indistinguishable from the endogenous hormone. Levothyroxine is nearly totally bound to serum proteins and…

LEVOPHED® Sanofi Norepinephrine Bitartrate Sympathomimetic Action And Clinical Pharmacology: Norepinephrine functions as a powerful peripheral vasoconstrictor (alpha-adrenergic action) and as a potent inotropic stimulator of the heart and dilator of coronary arteries (beta-adrenergic action). Both of these actions result in an increase in systemic blood pressure and coronary artery blood flow. Cardiac output will vary reflexly in response to systemic hypertension but is usually increased in hypotensive man when the…

LEVSIN® Rivex Pharma Hyoscyamine Sulfate Antispasmodic Action And Clinical Pharmacology: Hyoscyamine inhibits specifically the actions of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These peripheral cholinergic receptors are present in the autonomic effector cells of the smooth muscle, cardiac muscle, the sinoatrial node, the atrioventricular node, and the exocrine glands. It is completely devoid of any action…

LEVOVIST® Berlex Canada Galactose – Palmitic Acid Ultrasound Contrast Agent Action And Clinical Pharmacology: Levovist is an ultrasound contrast agent consisting of granules which are composed of 99.9% galactose and 0.1% palmitic acid. Prior to use, Levovist must be reconstituted with sterilized water for injections and shaken vigorously by hand for 5 to 10 seconds. After injection of the suspension into a peripheral vein, Levovist leads to temporarily enhanced ultrasound…

LEUCOVORIN CALCIUM INJECTION Faulding Citrovorum Factor Folic Acid Derivative Action And Clinical Pharmacology: Leucovorin is a reduced form of folic acid, which is readily converted to other reduced folic acid derivatives (e.g., tetra-hydrofolate). Because it does not require reduction by dihydrofolate reductase as does folic acid, leucovorin is not affected by blockages of this enzyme by folic acid antagonists (dihydrofolate reductase inhibitors). This allows purine and thymidine synthesis, and thus…

LEUKERAN® Glaxo Wellcome Chlorambucil Antineoplastic Agent Action And Clinical Pharmacology: Chlorambucil is an aromatic nitrogen mustard derivative which acts as a bifunctional alkylating agent. Alkylation takes place through the formation of a highly reactive ethylenimonium radical. A probable mode of action involves cross-linkage of the ethylenimonium derivative between two strands of helical DNA and subsequent interference with replication. After oral administration of carbon-14 labelled chlorambucil, maximum plasma radioactivity occurs between…

LEUSTATIN® Janssen-Ortho Cladribine Antineoplastic – Chemotherapeutic Agent Warning: Cladribine should be administered under the supervision of a qualified physician experienced in the use of antineoplastic therapy. Suppression of bone marrow function should be anticipated. This is usually reversible and appears to be dose-dependent. Significant and prolonged lymphopenia has been noted. Serious neurological toxicity (including irreversible paraparesis and quadriparesis) has been reported in patients who received cladribine injection by continuous infusion…

LECTOPAM® Roche Bromazepam Anxiolytic – Sedative Action And Clinical Pharmacology: Bromazepam is a benzodiazepine with anxiolytic and sedative properties which are of value in the symptomatic relief of pathological anxiety in psychoneurotic patients. The absolute bioavailability of unchanged, orally administered bromazepam is 60%, and peak blood levels are achieved within 2 hours after administration. On average, 70% of bromazepam is bound to plasma proteins. Bromazepam is metabolized in the liver,…

LEDERLE LEUCOVORIN® CALCIUM Wyeth-Ayerst Citrovorum Factor Folic Acid Derivative Action And Clinical Pharmacology: Lederle Leucovorin Calcium (calcium folinate), the calcium salt of folinic acid (citrovorum factor), is a mixture of the diastereoisomers of the 5-formyl derivative of tetrahydrofolic acid. The biologically active compound of the mixture is the (-)-L-isomer. It is a metabolite of folic acid and an essential coenzyme for nucleic acid synthesis. Leucovorin is a reduced form of…