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PROVERA® Pharmacia & Upjohn Medroxyprogesterone Acetate Progestin Action And Clinical Pharmacology: Medroxyprogesterone, an orally active progestational steroid (progestin) derived from a natural source (soy beans), when administered to women with adequate levels of estrogen (endogenous or exogenous), transforms a proliferative endometrium into a secretory endometrium. Furthermore, the anticancer activity of medroxyprogesterone at pharmacologic doses, may be dependent on its effect on the hypothalamic/pituitary/gonadal axis, estrogen receptors and metabolism of steroids…

PROVIODINE® Rougier Povidone-Iodine Antiseptic Action And Clinical Pharmacology: Proviodine is iodine complexed with povidone (polyvinyl-pyrrolidone). The compound is soluble in water forming a golden brown solution. Like iodine, the solution of the iodine complex is bactericidal and fungicidal. However, unlike solutions of iodine, it is non-staining. The antiseptic action of povidone-iodine solutions is due to the available iodine present in the complex. Indications And Clinical Uses: Derma: Useful as a…

PROZAC® Lilly Fluoxetine HCl Antidepressant – Antiobsessional – Antibulimic Action And Clinical Pharmacology: The antidepressant, antiobsessional, and antibulimic actions of fluoxetine are presumed to be linked to its ability to selectively inhibit the neuronal reuptake of serotonin. At clinically relevant doses fluoxetine blocks the uptake of serotonin into human platelets. Antagonism of muscarinic, histaminergic and a1-adrenergic receptors has been hypothesized to be associated with various anticholinergic, sedative and cardiovascular effects…

PROSTIN® E2 Pharmacia & Upjohn Dinoprostone Prostaglandin Action And Clinical Pharmacology: Orally administered dinoprostone stimulates the myometrium of the gravid uterus to contract in a manner that is similar to the contractions observed in the term uterus during spontaneous labor. Whether or not this action results from a direct or indirect effect of dinoprostone on the myometrium has not been determined with certainty. Dinoprostone’s ability to stimulate gastrointestinal tract smooth…

PROSTIN® VR Pharmacia & Upjohn Alprostadil Prostaglandin Action And Clinical Pharmacology: Alprostadil (also known as prostaglandin E1) relaxes the ductus arteriosus in early postnatal life and supports its patency when continuously infused i.v. or intra-arterially in neonates with congenital heart defects who depend on a patent ductus for survival. The desired pharmacological effects are obtained with an initial dosage of 0.1 µg/kg/minute. Higher doses do not offer added benefit. Postnatally…

PROSTIN® E2 Vaginal Gel Pharmacia & Upjohn Dinoprostone Prostaglandin Action And Clinical Pharmacology: Dinoprostone is a synthetic analogue of Prostaglandin E2 (PGE2). The major clinical application of PGE2 relates to its effect on uterine smooth muscle. This property has led to its obstetrical use for term labor induction and preterm evacuation of uterine contents (for fetal death in utero, hydatidiform mole and abortion). Similarly, this effect on other smooth muscle…

PROTAMINE SULFATE INJECTION Pharmaceutical Partners Heparin Antagonist Action And Clinical Pharmacology: When administered alone, protamine has an anticoagulant effect. However, when it is given in the presence of heparin (which is strongly acidic), a stable salt is formed which results in the loss of anticoagulant activity of both drugs. Protamine has a rapid onset of action. Neutralization of heparin occurs within 5 minutes after i.v. administration. Although the metabolic fate…

PROPYL-THYRACIL® Frosst Propylthiouracil Hyperthyroidism Therapy Indications And Clinical Uses: The medical management of hyperthyroidism. The treatment of thyrotoxicosis prior to surgery. In conjunction with radioiodine to hasten recovery while awaiting the effects of radiation. The management of thyroid storm in addition to other therapeutic measures. Contra-Indications: Lactation. Hypersensitivity or idiosyncratic reaction to propylthiouracil. Manufacturers’ Warnings In Clinical States: Pregnancy: Propylthiouracil readily crosses the placenta and can cause goiter or cretinism…

PROSCAR® MSD Finasteride 5 Alpha-reductase Inhibitor Action And Clinical Pharmacology: Finasteride is a synthetic 4-azasteroid compound which is a competitive and specific inhibitor of 5 alpha-reductase, an intracellular enzyme which metabolizes testosterone into the more potent androgen dihydrotestosterone (DHT). Finasteride has very low affinity for the androgen receptor. Benign prostatic hyperplasia (BPH) is a common finding in men over the age of 50 and its prevalence increases with age. The…

Bionutrix Prostanutrix Prostanutrix is a premium designer organic herbal supplement uniquely formulated by Bionutrix physicians to improve and optimize prostate health. This trademark formulation contains a specially balanced organic blend of saw palmetto and pygeum, the only two herbs that have been medically proven to safely and effectively treat and prevent prostate disorders and strengthen libido. Bionutrix is the only company to offer this potent prostate-specific formula in a reliably…