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PACLITAXEL INJECTION Boehringer Ingelheim Antineoplastic Caution: Paclitaxel is a toxic product and should be administered only by or under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Patients receiving paclitaxel injection should be pre-treated using corticosteroids, antihistamines, and H2 antagonists (for example dexamethasone, diphenhydramine and cimetidine or ranitidine) to minimize hypersensitivity reactions (see Dosage). All clinical studies referred to in this product monograph were conducted…

PURIFIED PROTEIN DERIVATIVE Connaught PPD-B (Mantoux) Diagnostic Antigen Indications And Clinical Uses: If there is reason to believe that an individual is infected with a mycobacterium other than M. tuberculosis var. hominis, as an added diagnostic procedure, PPD-B (Mantoux), 0.05 g per test dose may be injected using Tuberculin PPD (Mantoux), 5 TU (bioequivalent) per test dose, as a control. Injections are usually made in the same forearm not less…

PURINETHOL® Glaxo Wellcome Mercaptopurine Antileukemic Action And Clinical Pharmacology: Clinical studies have shown the absorption of an oral dose of mercaptopurine in man is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown. I.V. administration of an investigational preparation of mercaptopurine revealed a plasma half-disappearance time of 21 minutes in children and 47 minutes in adults. The volume of distribution usually exceeded that…

PYRIBENZAMINE® Novartis Consumer Health Tripelennamine HCl Antihistamine Indications And Clinical Uses: Seasonal or nonseasonal allergic reactions. Precautions: Occupational Hazards: Patients should be cautioned not to operate vehicles or hazardous machinery until their response to the drug has been determined. Since the depressant effects of antihistamines are additive to those of other drugs affecting the CNS, patients should be cautioned against drinking alcoholic beverages or taking hypnotics, sedatives, psychotherapeutic agents or…

gasPYLORID® Glaxo Wellcome Ranitidine Bismuth Citrate Histamine H2-receptor Antagonist with H. pylori Suppressive Activity Note: For additional safety information on clarithromycin and ranitidine, consult the individual product monographs. Action And Clinical Pharmacology: Ranitidine bismuth citrate is a complex of ranitidine, a histamine H2-receptor antagonist, and bismuth citrate, which together produce H. pylori suppressive activity. Following ingestion, ranitidine bismuth citrate dissociates in intragastric fluid, giving rise to ranitidine, and soluble and…

PULMICORT® NEBUAMP® Astra Budesonide Glucocorticosteroid – Asthma Therapy Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency and it is rapidly biotransformed in the liver. This favorable separation between topical anti-inflammatory activity and systemic effect is due to strong glucocorticosteroid receptor affinity and an effective first pass metabolism with a short half-life. The late…

PULMICORT® TURBUHALER® Astra Budesonide Glucocorticosteroid for the Treatment of Bronchial Asthma Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency and it is rapidly biotransformed in the liver. This favorable separation between topical anti-inflammatory activity and systemic effect is due to strong glucocorticosteroid receptor affinity and an effective first pass metabolism with a short…

PULMOZYME™ Roche Dornase Alfa Recombinant Enzyme that Cleaves DNA Action And Clinical Pharmacology: Dornase alfa for inhalation is a sterile, clear, colorless, highly purified solution of recombinant human deoxyribonuclease 1 (rhDNase), an enzyme which selectively cleaves DNA. The protein is produced by genetically engineered Chinese Hamster Ovary (CHO) cells containing DNA encoding for the native human protein, deoxyribonuclease 1 (Dnase). The product is purified by tangential flow filtration and column…

PUREGON™ Organon Follitropin Beta Gonadotropin Action And Clinical Pharmacology: Puregon is a freeze-dried preparation containing highly purified human follicle stimulating hormone (hFSH) prepared by recombinant DNA technology. The active substance, follitropin beta, is a heterodimeric glycoprotein with a molecular mass of approximately 35-45kD. It is produced by a Chinese hamster ovary (CHO) cell line transfected with a plasmid containing two subunit genes encoding human FSH. Structural analysis has shown that…

PROTROPIN® Roche Somatrem Growth Hormone Action And Clinical Pharmacology: Somatrem is a polypeptide (methionyl human growth hormone) produced by recombinant DNA technology using the gene for human growth hormone. Somatrem has the same amino acid sequence as pituitary-derived human growth hormone plus an additional amino acid, methionine, on the N-terminus of the molecule. The two molecules also have the same disulfide bond arrangement and the same secondary and tertiary structure….