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DELTASONE® Pharmacia & Upjohn Prednisone Corticosteroid Action And Clinical Pharmacology: Prednisone is a corticosteroid, which like other steroids, acts by controlling the rate of synthesis of proteins. The corticosteroids react with receptor proteins in the cytoplasm of sensitive cells to form a steroid-receptor complex. The steroid receptor complex moves into the nucleus where it binds to chromatin. Information carried by the steroid or more likely by the receptor protein directs…

DEMEROL® Sanofi Meperidine HCl Analgesic Action And Clinical Pharmacology: Meperidine is an opioid analgesic which acts predominantly as a mu-agonist. In its effects on the CNS, meperidine resembles but is not identical to morphine. Analgesic effects are detectable within about 15 minutes following oral administration, reaching a peak within about 2 hours and subsiding gradually over several hours thereafter. Onset of analgesic effect is faster (within 10 minutes) after s.c….

DEMADEX® Roche Torsemide Diuretic – Antihypertensive Action And Clinical Pharmacology: Mechanism of Action: Micropuncture studies in animals have shown that torsemide acts from within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the NaK2Clcarrier system. Clinical pharmacology studies have confirmed this site of action in humans, and effects in other segments of the nephron have not been demonstrated. Diuretic activity thus correlates better…

DECLOMYCIN® Wyeth-Ayerst Demeclocycline HCl Antibiotic Indications And Clinical Uses: Many strains of bacteria have been shown to be resistant to the tetracyclines. These include certain strains of streptococci, staphylococci, pneumococci, gonococci, and many other gram-negative organisms. Therefore, culture and sensitivity testing are advised to determine the susceptibility of the infecting organisms to tetracyclines. Chemotherapy should not be initiated until all the necessary bacteriological investigations have been started. Microorganisms that have…

DECA-DURABOLIN® Organon Nandrolone Decanoate Androgenic – Anabolic Steroid Indications And Clinical Uses: As adjunctive therapy in senile and postmenopausal osteoporosis. Anabolic steroids are without value as primary therapy but may be of value in adjunctive therapy. Equal or greater consideration should be given to diet, calcium balance, physiotherapy and good general health promoting measures, in pituitary dwarfism anabolic agents may be used with care until growth hormone is more available….

DELATESTRYL® Squibb Testosterone Enanthate Androgen Indications And Clinical Uses: Androgen therapy in the male (eunuchism, eunuchoidism, impotence of glandular origin, cryptorchidism, climacteric, senile pruritus), and in the female (menorrhagia, frigidity, palliation of premenopausal mammary carcinoma, inhibition of lactation, postpartum breast engorgement, menopausal syndrome), and in males and females (delayed bone healing, spinal paraplegia, senile osteoporosis, dystrophy, cachexia due to wasting illness). Contra-Indications: Androgens are contraindicated in male patients with prostatic…

DELESTROGEN® Squibb Estradiol Valerate Estrogen Indications And Clinical Uses: In nonpregnant women, Delestrogen is indicated in the treatment of amenorrhea (primary and secondary); disturbances of the menstrual cycle (hypomenorrhea, oligomenorrhea, irregular cycles, metrorrhagia); deficiency syndromes (castration, primary ovarian failure, menopause); local manifestations of estrogen deficiency (senile vaginitis, pruritus vulvae); abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology; and for the production of secretory endometrium and…

DDAVP® Tablets Ferring Desmopressin Acetate Antidiuretic Action And Clinical Pharmacology: Desmopressin is a synthetic structural analogue of the antidiuretic hormone, arginine vasopressin, which alters the permeability of the renal tubule to increase resorption of water. The increase in the permeability of both the distal tubules and collecting ducts appears to be mediated by a stimulation of the adenylcyclase activity in the renal tubules. Although the bioavailability of orally ingested desmopressin…

DDAVP® Spray and Rhinyle Nasal Solutions Ferring Desmopressin Acetate Antidiuretic Action And Clinical Pharmacology: Desmopressin is a synthetic structural analogue of the antidiuretic hormone, arginine vasopressin, which alters the permeability of the renal tubule to increase resorption of water. The increase in the permeability of both the distal tubules and collecting ducts appears to be mediated by a stimulation of the adenylcyclase activity in the renal tubules. Approximately 10 to…

DECADRON® Tablets MSD Dexamethasone Corticosteroid Indications And Clinical Uses: Allergic States: Control of severe or incapacitating allergic conditions not responsive to adequate trials of conventional treatment: seasonal or perennial allergic rhinitis, bronchial asthma, contact dermatitis, atopic dermatitis, serum sickness, drug hypersensitivity reactions. Rheumatic Disorders: as adjunctive therapy for short-term administration during an acute episode or exacerbation of: psoriatic arthritis, rheumatoid arthritis including juvenile rheumatoid arthritis (selected cases may require low-dose…