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DIANE®-35 Berlex Canada Cyproterone Acetate – Ethinyl Estradiol Acne Therapy Action And Clinical Pharmacology: Diane-35 is a combination antiandrogen-estrogen for use in the treatment of androgen-dependent dermatological conditions in females. Cyproterone is a steroid compound with potent antiandrogenic, progestogenic and antigonadotrophic activity. It exerts its antiandrogenic effect by blocking androgen receptors. It also reduces androgen synthesis by a negative feedback effect on the hypothalamo-pituitary-ovarian systems. The estrogen component (ethinyl estradiol)…

DIAZEMULS® Pharmacia & Upjohn Diazepam Injectable Emulsion Anxiolytic – Sedative Action And Clinical Pharmacology: Diazemuls is an injectable emulsion of diazepam, a drug with known anxiolytic-sedative and muscle relaxant properties. Diazepam has been found useful for short-term symptomatic relief of excessive anxiety and tension in patients with anxiety neurosis, although anxiety and tension associated with the stresses of everyday life usually do not require treatment with anxiolytic drugs. Diazepam must…

DESYREL® DESYREL® DIVIDOSE Bristol Trazodone HCl Antidepressant Action And Clinical Pharmacology: Trazodone is a psychoactive compound with sedative and antidepressant properties. Its mechanism of action in humans is not clear. Trazodone is well absorbed after oral administration with peak plasma levels obtained within 0.5 to 2 hours after ingestion. Absorption is somewhat delayed and enhanced by food. The mean plasma elimination half-life is 4.4 hours for the period from 3…

DEXEDRINE® SmithKline Beecham Dextroamphetamine Sulfate Sympathomimetic Action And Clinical Pharmacology: Dextroamphetamine (dexamphetamine, d-amphetamine) sulfate is a sympathomimetic agent with indirect effects on adrenergic receptors. It has alpha-and beta-adrenergic activity. It has actions qualitatively similar to those of amphetamine sulfate but is approximately twice as potent. It has a marked stimulant effect on the CNS, particularly the cerebral cortex and the respiratory and vasomotor centers. Dextroamphetamine sulfate causes a lessening of…

DEXIRON™ Genpharm Iron Dextran Hematinic – Iron Supplement Action And Clinical Pharmacology: Iron dextran is absorbed from i.m. injection sites into the capillaries and the lymphatic system. Circulating iron dextran is removed from the plasma by cells of the reticuloendothelial system, which split the complex into its components of iron and dextran. The iron is immediately bound to the available protein moieties to form hemosiderin or ferritin, the physiologic forms…

DIABINESE™ Pfizer Chlorpropamide Oral Hypoglycemic Action And Clinical Pharmacology: Chlorpropamide is an orally active hypoglycemic agent which reduces blood sugar concentration without affecting glucose tolerance. It probably acts by stimulating insulin secretion in the presence of functioning pancreatic islet tissue. Chlorpropamide is absorbed readily from the gastrointestinal tract and is bound to plasma proteins. Within 1 hour after a single oral dose, it is detectable in the blood, and the…

DIABETA® Hoechst Marion Roussel Glyburide Oral Hypoglycemic Action And Clinical Pharmacology: The principal action of glyburide results in an increased insulin release from the beta cells of the pancreas. Other mechanisms leading to a reduction of blood glucose are also believed to be influenced by glyburide. The insertion of an alkylene chain on the benzene nucleus results in a product of very high potency. Schulz and Schmidt indicated that the…

DESFERAL® Novartis Pharmaceuticals Deferoxamine Mesylate Iron and Aluminum Chelating Agent Action And Clinical Pharmacology: Deferoxamine is a chelating agent which forms complexes predominantly with trivalent iron and aluminum ions; it is thus of value in the treatment of acute/chronic iron intoxication, and also chronic aluminum overload in dialysis patients with end-stage renal failure (ESRF). Deferoxamine complexes with iron to form ferrioxamine, a stable chelate, which cannot take part in further…

DESOCORT® Galderma Desonide Topical Corticosteroid Action And Clinical Pharmacology: Desonide, like all topical corticosteroids, exhibits anti-inflammatory, antipruritic and vasoconstrictive actions. tag_IndicationsIndications Indications And Clinical Uses: For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Contra-Indications: Tuberculous, fungal and most viral lesions of the skin (including herpes simplex, vaccinia and varicella). Hypersensitivity to any of the components. Not for ophthalmic use. Precautions: General: Systemic absorption of topical corticosteroids…

DEPROIC® Technilab Valproic Acid Anticonvulsant Action And Clinical Pharmacology: Valproic acid exhibits anticonvulsant properties. While the exact mechanism of action is unknown, several investigators have proposed that the anticonvulsive effect of valproic acid can be related to increased gamma-amino-butyric acid (GABA) levels in the brain. The effect on the neuronal membrane is unknown. After oral administration, valproic acid is rapidly absorbed, reaching peak serum levels within 1 to 4 hours….