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DIMETAPP®-C Whitehall-Robins Brompheniramine Maleate – Codeine Phosphate – Phenylephrine HCl – Phenylpropanolamine HCl Antihistamine – Cough Suppressant – Decongestant Indications And Clinical Uses: For the symptomatic relief of coughing, nasal congestion, runny nose, sneezing and lacrimation accompanying the common cold and other upper respiratory infections. Contra-Indications: Hypersensitivity to any of the ingredients, marked hypertension and in patients receiving MAO inhibitors. Precautions: Administer with caution to patients with cardiac or peripheral…

DIMENHYDRINATE INJECTION Astra Antiemetic Action And Clinical Pharmacology: While the precise mode of action of dimenhydrinate is not known, it has a depressant action on hyperstimulated labyrinthine functions or associated neural pathways. Indications: Prevention and relief of motion sickness and the nausea or vomiting incident to these conditions. The treatment or prophylaxis of the nausea and vomiting of radiation sickness, postoperative vomiting, and drug-induced nausea and vomiting; also for the…

DIMETANE® EXPECTORANT Whitehall-Robins Brompheniramine Maleate – Guaifenesin – Phenylephrine HCl – Phenylpropanolamine HCl Antihistamine – Expectorant – Decongestant Indications And Clinical Uses: For the temporary relief of coughing and the complications of allergy states, including perennial and seasonal allergic rhinitis. In addition, indicated for the symptomatic relief of cough, nasal congestion and runny nose accompanying the common cold and other respiratory tract infections. Contra-Indications: Hypersensitivity to any of the components;…

DIMETANE® EXPECTORANT-C DIMETANE® EXPECTORANT-DC Whitehall-Robins Brompheniramine Maleate – Phenylephrine HCl – Phenylpropanolamine HCl – Guaifenesin – Codeine Phosphate Brompheniramine Maleate – Phenylephrine HCl – Phenylpropanolamine HCl – Guaifenesin – Hydrocodone Bitartrate Antihistamine – Decongestant – Expectorant – Antitussive Indications And Clinical Uses: The temporary relief of coughing and the complications of allergic states including manifestations such as perennial and seasonal allergic rhinitis. The symptomatic relief of cough, nasal stuffiness and…

DILAUDID® Knoll Hydromorphone HCl Analgesic – Antitussive Action And Clinical Pharmacology: Hydromorphone has a strong analgesic action and antitussive activity. Small doses of hydromorphone produce effective and prompt relief of pain usually with minimal nausea and vomiting. Generally, when given parenterally, hydromorphone’s analgesic action is apparent within 15 minutes and remains in effect for more than 5 hours. The onset of action of oral hydromorphone is somewhat slower, with measurable…

DILANTIN® CAPSULES Parke-Davis Phenytoin Sodium Anticonvulsant Action And Clinical Pharmacology: Phenytoin is an anticonvulsant drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient….

DILAUDID-HP® DILAUDID-HP-PLUS® DILAUDID-XP® DILAUDID® STERILE POWDER Knoll Hydromorphone HCl Opioid Analgesic Action And Clinical Pharmacology: Hydromorphone is a hydrogenated ketone of morphine. It is an opioid analgesic with many of the effects common to the class of drugs. Opioid analgesics have multiple actions but exert their primary effects on the CNS and organs containing smooth muscle. The principal actions of therapeutic value are analgesia and sedation. Opioid analgesics also suppress…

DILTIAZEM HYDROCHLORIDE INJECTION Novopharm Antiarrhythmic Action And Clinical Pharmacology: Diltiazem inhibits the influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle. The therapeutic benefits of diltiazem in supraventricular tachycardias are related to its ability to slow atrioventricular (AV) nodal conduction time and prolong AV nodal refractoriness. Diltiazem exhibits frequency (use) dependent effects on AV nodal conduction such that it may selectively reduce the heart rate during…

DIFLUCAN™ Pfizer Fluconazole Antifungal Agent Action And Clinical Pharmacology: Fluconazole is a highly selective inhibitor of fungal cytochrome P450 sterol C-14-alpha-demethylation. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. The subsequent loss of normal sterols correlates with the accumulation of 14-a-methyl sterols in fungi and may be responsible for the fungistatic activity of fluconazole. Fluconazole is a polar bis-triazole antifungal drug. Studies have shown that fluconazole exhibits specificity…

DIGIBIND® Glaxo Wellcome Digoxin Immune Fab (Ovine) Specific Antibody for Digoxin Action And Clinical Pharmacology: Digoxin immune Fab (ovine) is a sterile lyophilized powder of antigen binding fragments (Fab) derived from specific antidigoxin antibodies raised in sheep. It binds molecules of digoxin, making them unavailable for binding at their site of action on cells in the body. The Fab fragment-digoxin complex accumulates in the blood, from which it is excreted…