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Brand Names: HIBITANE® Skin Cleanser Manufacturer: Zeneca Generic Name: Chlorhexidine Gluconate Use: Antibacterial Skin Cleanser Action And Clinical Pharmacology Chlorhexidine is effective against a wide range of gram-negative and gram-positive vegetative bacteria, yeasts, dermatophyte fungi and lipophilic viruses. It is inactive against bacterial spores except at elevated temperatures. Because of its cationic nature, chlorhexidine binds strongly to skin, mucosa and other tissues and is thus very poorly absorbed. No detectable blood levels have…

HEPARINS: LOW MOLECULAR WEIGHT General Monograph, Dalteparin Enoxaparin Nadroparin Tinzaparin Anticoagulant Action And Clinical Pharmacology: Low molecular weight heparins (LMWHs) are fragments of heparin produced by enzymatic or chemical depolymerization. They have an average molecular weight of 4 000 to 5 000 daltons (range 1 000 to 10 000 daltons) which is approximately one-third that of standard heparin. Most heparin molecules with molecular weights smaller than 5 400 daltons are…

HEXABRIX® 200 HEXABRIX® 320 Mallinckrodt Ioxaglate Meglumine – Ioxaglate Sodium Radiopaque Medium Action And Clinical Pharmacology: Following intravascular injection, Hexabrix is rapidly transported through the circulatory system to the kidneys and is excreted unchanged in the urine. The pharmacokinetics of intravascularly administered radiopaque contrast media are usually best described by a two compartment model with a rapid alpha phase for drug distribution and a slower beta phase for drug elimination….

HEXADROL® PHOSPHATE INJECTION Organon Teknika Dexamethasone Sodium Phosphate Corticosteroid Action And Clinical Pharmacology: After administration of the injection, dexamethasone sodium phosphate is rapidly converted into dexamethasone. This is a synthetic glucocorticoid which has 7 times the anti-inflammatory potency of prednisolone. Like other glucocorticoids, dexamethasone also has antiallergic, antitoxic, antishock, antipyretic and immunosuppressive properties. Dexamethasone has practically no water and salt-retaining properties and is, therefore, particularly suitable for use in patients…

HEXALEN® Lilly Altretamine Antineoplastic Agent Action And Clinical Pharmacology: Altretamine, better known in the scientific literature as hexamethylmelamine (HMM), is a synthetic cytotoxic antineoplastic s-triazine derivative. While altretamine bears structural similarity to, and cross-reactivity with, triethylenemelamine (TEM), a classical alkylating agent, evidence demonstrating altretamine to be an alkylating agent is not conclusive. Altretamine does not consistently demonstrate cross-resistance with classical alkylating agents used in rodent tumors or in human cancer…

HEALON® HEALON® GV Pharmacia & Upjohn Sodium Hyaluronate Ophthalmosurgical Aid Description: Sodium hyaluronate is a sterile, nonpyrogenic, viscoelastic preparation of a highly purified, noninflammatory, high molecular weight fraction of sodium hyaluronate. Healon contains 10 mg/mL of sodium hyaluronate 5 000 and Healon GV contains 14 mg/mL of sodium hyaluronate 7 000 dissolved in physiological sodium chloride-phosphate buffer (pH 7.0 to 7.5). This high molecular weight polymer is made up of…

HEPALEAN® Organon Teknika Heparin Sodium Anticoagulant Indications And Clinical Uses: Used in the treatment of thrombophlebitis, phlebothrombosis, and cerebral, coronary, and retinal vessel thrombosis to prevent extension of clots and thromboembolic phenomena. Also used prophylactically to prevent the occurrence of thromboembolism, and to prevent clotting during dialysis and other surgical procedures, particularly vascular surgery. When using in conjuction with dialysis machines or where heparin is added to glucose or saline…

HEPARIN LEO® Leo Heparin Sodium Anticoagulant Action And Clinical Pharmacology: Heparin is an anticoagulant which prevents the formation of thrombin by accelerating the neutralization of activated coagulation factors by naturally occurring inhibitors. Indications And Clinical Uses: For the prophylaxis and management of intravascular clotting and embolism in susceptible patients. It is also used in extra-corporeal circulation, i.e. heart-lung and renal dialysis machines and blood transfusions. Contra-Indications: Hemorrhagic disorders and patients…

HEPARIN: UNFRACTIONATED General Monograph Heparin Sodium Anticoagulant Action And Clinical Pharmacology: Heparin is a heterogeneous preparation of sulfated mucopolysaccharide polymers whose molecular weights range from 3 000 to 30 000 daltons, averaging between 12 000 and 15 000 daltons. Heparin exerts its anticoagulant activity by reversibly binding to antithrombin III (AT III), accelerating the ability of AT III to neutralize thrombin and activated coagulation factor X (Xa). The heparin-AT III…

HALOG® Preparations Westwood-Squibb Halcinonide Topical Corticosteroid Indications And Clinical Uses: Halcinonide, a synthetic fluorinated corticosteroid, is indicated for topical application for the relief of the inflammatory manifestations of acute or chronic corticosteroid responsive dermatoses; under occlusion, in the management of recalcitrant cases of psoriasis and neurodermatitis. Contra-Indications: Tuberculous, fungal and most viral lesions of the skin (including herpes simplex, vaccinia, and varicella). Patients with history of hypersensitivity to any of…