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HYCODAN® DuPont Pharma Hydrocodone Bitartrate Antitussive Action And Clinical Pharmacology: Clinical trials have proven hydrocodone bitartrate to be an effective antitussive agent which is pharmacologically 2 to 8 times as potent as codeine. At equi-effective doses, its sedative action is greater than that of codeine. The precise mechanisms of action of hydrocodone and other opiates are not known; however, hydrocodone is believed to act by directly depressing the cough centre….

HONVOL® Carter Horner Diethylstilbestrol Diphosphate Prostatic Carcinoma Therapy Indications And Clinical Uses: For intensive and selective palliative therapy of inoperable prostatic carcinoma. Contra-Indications: Patients with active hepatic dysfunction or disease, especially of the obstructive type; a personal history of breast cancer, except in special circumstances; a history of cerebrovascular accident, coronary thrombosis or the presence of classical migraine; a history of thrombophlebitis or thromboembolic disease; partial or complete loss of…

HUMALOG™ Lilly Insulin Lispro Antidiabetic Agent Action And Clinical Pharmacology: Insulin lispro is a rapid-acting analogue of human insulin. Due to its quick onset of action, insulin lispro should be given within 15 minutes of a meal. Insulin lispro is created by inverting the natural Pro-Lys sequence in human insulin at positions 28 and 29 in the C terminal portion of the B-chain. This change in amino acid sequence slightly…

HUMATROPE® Lilly Somatropin Growth Stimulant Action And Clinical Pharmacology: Somatropin is a polypeptide hormone of recombinant DNA origin. The amino acid sequence is identical to that of human growth hormone of pituitary origin. Somatropin is synthesized in a strain of E. coli which has been modified by the addition of the gene for human growth hormone. Somatropin stimulates linear growth in pediatric patients lacking adequate normal endogenous growth hormone. Treatment…

HUMATIN™ Parke-Davis Paromomycin Sulfate Antibiotic Action And Clinical Pharmacology: Paromomycin is a broad spectrum aminoglycoside antibiotic produced by S. rimosus var. paromomycinus. The drug is structurally related to neomycin, streptomycin and kanamycin. It is poorly absorbed after oral administration with almost 100% of the drug recoverable in the stool. Paromomycin is considered a luminal or contact amebicide since it acts principally in the intestinal lumen. Unlike tetracyclines, paromomycin is a…

HISTAMINE Bioniche Histamine Phosphate Diagnostic Aid Indications And Clinical Uses: To test the ability of the gastric mucosa to produce hydrochloric acid. Contra-Indications: The gastric histamine test is contraindicated in patients with a history of hypersensitivity to histamine products, in patients with hypotension, severe hypertension, vasomotor instability, bronchial asthma (past or present), urticaria (past or present), or severe cardiac, pulmonary or renal disease. Precautions: Attacks of severe asthma or other…

HISMANAL® Johnson & Johnson Merck Astemizole Histamine H1-Antagonist Action And Clinical Pharmacology: Astemizole is a potent, long-acting, and selective histamine H1-antagonist. It produces a dose-related inhibition of skin reactions to intradermal histamine. Astemizole inhibits the nose reaction to nasal challenge with histamine and allergens. It inhibits the bronchial reaction to inhaled histamine and allergens in asthmatic patients. Astemizole has extremely weak serotonin antagonism, no anticholinergic properties, antagonism of dopamine and…

HOMATROPINE General Monograph, Mydriatic – Cycloplegic – Anticholinergic Homatropine HBr is a tertiary amine anticholinergic agent used topically to produce mydriasis and cycloplegia. It blocks the responses of the iris sphincter and ciliary muscle to cholinergic stimuli. Homatropine is less potent than atropine and has a shorter duration of action. Complete cycloplegia is not usually attainable. The maximum mydriatic effect occurs in about 10 to 30 minutes, and the maximum…

HIVID® Roche Zalcitabine Antiretroviral Agent Action And Clinical Pharmacology: Zalcitabine is a synthetic nucleoside analogue of the naturally occurring nucleoside 2-deoxycytidine in which the 3-hydroxyl group is replaced by hydrogen. Within cells, zalcitabine is converted to the active metabolite, dideoxycytidine 5-triphosphate (ddCTP), by cellular enzymes. ddCTP serves as an alternative substrate to deoxycytidine triphosphate (dCTP) for HIV-reverse transcriptase and inhibits the in vitro replication of HIV-1 by inhibition of viral…

HIBIDIL® 1:2000 Zeneca Chlorhexidine Gluconate Antiseptic Action And Clinical Pharmacology: Chlorhexidine is effective against a wide range of gram-negative and gram-positive vegetative bacteria, yeasts, dermatophyte fungi and lipophilic viruses. It is inactive against bacterial spores except at elevated temperatures. Because of its cationic nature, chlorhexidine binds strongly to skin, mucosa and other tissues and is thus very poorly absorbed. No detectable blood levels have been found in man following oral…