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ADEKs® Pediatric Drops ADEKs® Tablets Axcan Pharma Multiple Vitamins – Zinc Sulfate Multiple Vitamins – Zinc Oxide Multiple Vitamin – Mineral Supplement Action And Clinical Pharmacology: Deficiencies of one or more of the fat-soluble vitamins may occur in the presence of steatorrhea or other malabsorption, hepatic dysfunction, protein malnutrition, zinc deficiency, and very low fat diets. As with all vitamins, adequate levels are essential to good health and proper growth….

ADALAT® Bayer Nifedipine Antianginal Action And Clinical Pharmacology: Nifedipine is a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist). The antianginal effect of this group of drugs is believed to be related to its specific cellular action of selectively inhibiting transmembrane influx of calcium ions into cardiac muscle and vascular smooth muscle. The contractile processes of these tissues are dependent upon the movement of extracellular calcium into…

ADALAT® PA 10 ADALAT® PA 20 Bayer Nifedipine Antihypertensive Action And Clinical Pharmacology: Nifedipine is a calcium ion influx inhibitor (calcium channel blocker or calcium ion antagonist). The antihypertensive action of this group of drugs is believed to be related to its specific cellular action of selectively inhibiting transmembrane influx of calcium ions into vascular smooth muscles. The contractile processes of vascular smooth muscle are dependent upon the movement of…

ADALAT® XL® Bayer Nifedipine Antianginal – Antihypertensive System Components and Performance: Adalat XL extended release tablets, while similar in appearance to a conventional tablet, nonetheless consist of a semipermeable membrane surrounding an osmotically active drug core. The core itself is divided into 2 layers: an “active” layer containing the drug, and a “push” layer containing pharmacologically inert, but osmotically active components. As water from the gastrointestinal tract enters the tablet,…

ADEKs® Pediatric Drops ADEKs® Tablets Axcan Pharma Multiple Vitamins – Zinc Sulfate Multiple Vitamins – Zinc Oxide Multiple Vitamin – Mineral Supplement Action And Clinical Pharmacology: Deficiencies of one or more of the fat-soluble vitamins may occur in the presence of steatorrhea or other malabsorption, hepatic dysfunction, protein malnutrition, zinc deficiency, and very low fat diets. As with all vitamins, adequate levels are essential to good health and proper growth….

ACTIVASE® rt-PA Roche Alteplase Fibrinolytic Agent Action And Clinical Pharmacology: Alteplase is a serine protease which has the property of fibrin-enhanced conversion of plasminogen to plasmin. It produces minimal conversion of plasminogen in the absence of fibrin; and when introduced into the systemic circulation, alteplase binds to fibrin in a thrombus and converts the entrapped plasminogen to plasmin. This initiates local fibrinolysis with minimal systemic effects. Following administration of alteplase…

AXID® Lilly Nizatidine Histamine H2 Receptor Antagonist Action And Clinical Pharmacology: Nizatidine is a competitive, reversible inhibitor of the histamine H2 receptor of gastric-acid secreting cells. Nizatidine is not an anticholinergic agent. It inhibits nocturnal gastric-acid secretion and gastric-acid secretion stimulated by food, caffeine, betazole and pentagastrin. Pepsin output is reduced in proportion to the reduced volume of gastric secretions. Nizatidine has little or no effect on basal serum gastrin…

AVC® Hoechst Marion Roussel Sulfanilamide Vaginitis Therapy Action And Clinical Pharmacology: Sulfanilamide has been an ingredient of vaginal formulations for about four decades. It blocks certain metabolic processes essential for the growth of susceptible bacteria. AVC Cream is buffered to the pH of the normal healthy vagina (approximately 4.3) to encourage the presence of normally occurring DSderlein bacilli of the vagina. Indications And Clinical Uses: For the treatment of vulvovaginitis…

ASTRACAINE® ASTRACAINE® FORTE Astra Articaine HCl – Epinephrine Local Anesthetic Action And Clinical Pharmacology: Articaine is a local anesthetic of the amide type. As with other local anesthetics, it prevents the generation and conduction of the nerve impulse by interfering with the large transient increase in the permeability of the membrane to sodium ions. Epinephrine acts on alpha-adrenergic receptors in the vasculature of the mucous membranes to produce vasoconstriction, thereby…

ASPIRIN® Bayer Consumer ASA Analgesic – Anti-inflammatory – Antipyretic – Platelet Aggregation Inhibitor Action And Clinical Pharmacology: ASA interferes with the production of prostaglandins in various organs and tissues through acetylation of the enzyme cyclo-oxygenase. Prostaglandins are themselves powerful irritants and produce headaches and pain on injection in man. Prostaglandins also appear to sensitize pain receptors to other noxious substances such as histamine and bradykinin. By preventing the synthesis and…