You searched for : 'K'

OXYTOCIN INJECTION, USP Abbott Oxytocic Action And Clinical Pharmacology: Oxytocin synthetic, acts on the smooth muscle of the uterus to stimulate contractions; response depends on the uterine threshold of excitability. It exerts a selective action on the smooth musculature of the uterus, particularly toward the end of pregnancy, during labor and immediately following delivery. Oxytocin stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions and raises the…

PROCAN™ SR Parke-Davis Procainamide HCl Antiarrhythmic Agent Action And Clinical Pharmacology: Procainamide depresses the excitability of cardiac muscle to electrical stimulation, and slows conduction in the atrium, the bundle of His, and the ventricle. The refractory period of the atrium is considerably more prolonged than that of the ventricle. With therapeutic plasma levels of the drug, contractility of the heart is usually not affected nor is cardiac output decreased to…

OXIZOLE® Stiefel Oxiconazole Nitrate Topical Antifungal Action And Clinical Pharmacology: Oxiconazole nitrate is a broad-spectrum imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has fungicidal or fungistatic activity in vitro against a number of pathogenic fungi including the following dermatophytes, and yeasts: T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini,…

OXSORALEN-ULTRA™ ICN Methoxsalen Melanin Repigmentation – Tolerance Increase to Solar Exposure – Photochemotherapy of Atopic Dermatitis and Psoriasis Indications And Clinical Uses: Repigmentation of idiopathic vitiligo; increasing tolerance to sunlight. Treatment of psoriasis and atopic dermatitis in combination with high intensity UVA light (photochemotherapy). Contra-Indications: Hepatic insufficiency and in those diseases associated with photosensitivity; such as porphyria, acute lupus erythematosus, hydroa and polymorphic light eruptions. In leukoderma of infectious origin…

OTRIVIN® Novartis Consumer Health Xylometazoline HCl Nasal Decongestant Indications And Clinical Uses: Nasal congestion in colds, rhinitis, sinusitis; also for headache, tubal block and serous otitis media associated with nasal congestion. Xylometazoline facilitates rhinoscopy and is a useful pre- and postoperative adjunct. Contra-Indications: Narrow-angle glaucoma. Concurrent therapy with MAO inhibitors. Hypersensitivity to any component. Sensitivity to even small doses of adrenergic substances as manifested by sleeplessness, dizziness, lightheadedness, weakness, tremulousness,…

OSTOFORTE® Frosst Vitamin D2 (Ergocalciferol) Vitamin Indications And Clinical Uses: Treatment of refractory rickets (vitamin D-resistant rickets), familial phosphatemia and hypoparathyroidism. Contra-Indications: Hypercalcemia, malabsorption syndrome, abnormal sensitivity to the toxic effects of vitamin D, hypervitaminosis D, decreased renal function. Precautions: Hypersensitivity to vitamin D may be one etiological factor in infants with idiopathic hypercalcemia. In these cases, vitamin D must be severely restricted. Pregnancy: Safety in excess of 400 IU…

OVOL® Preparations Carter Horner Simethicone Antiflatulent Indications And Clinical Uses: Specifically for symptomatic treatment of gastrointestinal discomfort due to entrapped gas. Relief of infant colic. Symptoms And Treatment Of Overdose: Symptoms and Treatment: Treatment symptomatic. Dosage And Administration: Drops: Infants, 0.25 to 0.50 mL with or after each meal. May be added to formula or given directly from dropper. Maximum: 6 mL/24 hours. Tablets: Adults: 40 mg (2 tablets, 4…

OXEZE® TURBUHALER® Astra Formoterol Fumarate Dihydrate Bronchodilator Action And Clinical Pharmacology: Pharmacodynamics: Formoterol produces bronchodilation by stimulation of the b2-adrenergic receptors in bronchial smooth muscle, thereby causing relaxation of smooth muscle fibres. Following inhalation of formoterol, a marked improvement in pulmonary function is observed within 1 to 3 minutes and lasts for a mean duration of 12 hours after a single dose. Pharmacokinetics: Absorption: Inhaled formoterol is rapidly absorbed. Peak…

OSMOVIST® Berlex Canada Iotrolan Dimeric Nonionic Radiographic Contrast Medium for Myelography Action And Clinical Pharmacology: Iotrolan is a dimeric, nonionic, hexaiodinated radiocontrast medium. The contrast-giving substance, iotrolan, is a dimer of triiodinated isophthalic acid derivatives, in which the firmly bound iodine absorbs the x-rays. Solutions of iotrolan are isotonic to plasma and cerebrospinal fluid at radiologically useful iodine levels. After intrathecal administration, iotrolan is absorbed from cerebrospinal fluid (CSF) into…

OSTAC® Roche Clodronate Disodium Bone Metabolism Regulator Action And Clinical Pharmacology: Clodronate belongs to the class of bisphosphonates which act primarily on bone. This tissue specificity is due to the high affinity of bisphosphonates for calcium phosphate crystals. Clodronate forms complexes with the hydroxyapatite of bone, altering the crystalline structure in such a way that dissolution of the crystals is inhibited. The major effect of clodronate is to inhibit osteoclast-mediated…