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POLYTRIM™ Allergan Trimethoprim Sulfate – Polymyxin B Sulfate Antibacterial Agent Action And Clinical Pharmacology: When used topically, trimethoprim and polymyxin B are rarely sensitizing and absorption through intact skin and mucous membrane is insignificant. Blood samples were obtained from 11 human volunteers at 20 minutes, 1 hour and 3 hours following instillation of 2 drops of a solution containing 1 mg trimethoprim and 10 000 units of polymyxin B/mL. On…

POLIOVIRUS VACCINE LIVE ORAL TRIVALENT Connaught Poliovirus Types 1, 2 and 3 Active Immunizing Agent Action And Clinical Pharmacology: The purpose of administering any attenuated, live virus vaccine is to stimulate the immune system to produce an active immunity by stimulating natural infection without producing clinical symptoms of the disease. To accomplish this with live poliovirus vaccine, it is necessary for the virus to multiply in the intestinal tract. A…

POLLINEX®-R Bencard Modified Ragweed Tyrosine Adsorbate Vaccine Action And Clinical Pharmacology: Pollinex-R is an aqueous extract of short ragweed pollen (Ambrosia elatior) chemically modified with gluteraldehyde adsorbed onto tyrosine and then suspended in saline. The exact mode of therapeutic action of Pollinex-R, as with other allergy vaccines, is unknown. It has been proposed the elevation of IgG blocking antibodies may interfere with the immediate hypersensitivity reaction of patients exposed to…

POLOCAINE® 3% POLOCAINE® 2% with LEVONORDEFRIN 1:20 000 Astra Mepivacaine HCl Mepivacaine HCl – Levonordefrin Local Anesthetic Action And Clinical Pharmacology: Mechanism of Action: Mepivacaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Local anesthetics of the amide type are thought to act within sodium channels of the nerve membrane. Onset of Action: Mepivacaine has a…

POLYCITRA-K® Alza Potassium Citrate Potassium Supplement Indications And Clinical Uses: Pleasant tasting, sugar-free, oral potassium citrate supplement. In the treatment or prevention of hypokalemia, treatment of digitalis intoxication, and for the treatment of potassium replacement and electrolyte recharge. Contra-Indications: Ventricular fibrillation, hyperkalemia of various etiologies, in association with Addison’s disease, suprarenal hyperplasia associated with a loss of salt, extensive tissue deterioration such as severe burns, acute dehydration and heat cramps….

PNU-IMUNE® 23 Wyeth-Ayerst Pneumococcal Vaccine Polyvalent Active Immunizing Agent Action And Clinical Pharmacology: Disease caused by S. pneumonia remains an important cause of morbidity and mortality particularly in the very young, the elderly and persons with certain high-risk conditions. The overall incidence of pneumococcal infections in Canada is not known. In 1992, 132 cases of pneumococcal meningitis were reported in Canada. In England, 34% of pneumonias in adults have been…

PNEUMOVAX® 23 MSD Pneumococcal Vaccine, Polyvalent Pneumococcal Infection Immunization Action And Clinical Pharmacology: Pneumococcal infection is a leading cause of death throughout the world and a major cause of pneumonia, meningitis and otitis media. The emergence of strains of pneumococci with increased resistance to one or more of the common antibiotics and recent isolations of pneumococci with multiple antibiotic resistance emphasize the importance of vaccine prophylaxis against pneumococcal disease. Based…

PODOFILM® Pharmascience Podophyllum Resin Wart Remover Indications And Clinical Uses: For the removal of benign epithelial growths such as venereal warts (condylomata acuminata), common warts (verruca vulgaris), and benign papillomas such as granuloma inguinale and plantar warts. Contra-Indications: Hypersensitivity to podophyllin. The consumption of alcoholic beverages for several hours after treatment, is to be avoided. Precautions: Podophyllin is an extremely potent vesicant and is to be applied only by the…

POLARAMINE® Schering Dexchlorpheniramine Maleate Antihistamine Indications And Clinical Uses: For symptomatic relief of allergic conditions such as hay fever, urticaria, angioedema, vasomotor rhinitis, allergic eczema, contact dermatitis, pruritus ani and vulvae, and pruritus of nonspecific origin, as well as in certain cases of migraine headache. Precautions: Occupational Hazards: Patients should be cautioned not to operate vehicles or hazardous machinery until their response to the drug has been determined. Since the…

PLAVIX™ Sanofi/Bristol-Myers Squibb Clopidogrel Bisulfate Platelet Aggregation Inhibitor Action And Clinical Pharmacology: Mechanism of Action: The role of platelets in the pathophysiology of atherosclerotic disease and thrombotic events has been established. Long-term prophylactic use of antiplatelet drugs has shown consistent benefit in the prevention of ischemic stroke, myocardial infarction and vascular death in patients at increased risk of such outcomes, including those with established atherosclerosis or a history of atherothrombosis….