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TUSSIONEX® Rhône-Poulenc Rorer Hydrocodone (Resin Complex)–Phenyltoloxamine (Resin Complex) Antitussive–Antihistamine Action and Clinical Hydrocodone is a semi-synthetic narcotic antitussive and analgesic with multiple actions qualitatively similar to those of codeine. As an antitussive, hydrocodone is approximately 3 times as potent as codeine on a weight for weight basis. The precise mechanism of action of hydrocodone and other opiates is not known; however, hydrocodone is believed to inhibit coughing by interfering with…

TUMS® Tablets SmithKline Beecham Consumer Healthcare Calcium Carbonate Calcium Supplement–Antacid Availability And Storage: Regular: Each tablet contains: calcium carbonate 500 mg equivalent to elemental calcium 200 mg. Security-sealed bottles of 75, 150, 180 and rolls of 12. Regular and assorted fruit flavors. Extra: Each tablet contains: calcium carbonate 750 mg equivalent to elemental calcium 300 mg. Security-sealed bottles of 50, 100, 120, 250 and rolls of 8. Regular, assorted mint,…

TROPICAMIDE Rivex Ophthalmics Mydriatic–Cycloplegic Availability And Storage: Each mL of sterile ophthalmic solution contains: tropicamide 1%. Nonmedicinal ingredients: benzalkonium chloride, boric acid, edetate disodium, hydrochloric acid, purified water and sodium hydroxide. Plastic squeeze bottles of 15 mL with controlled tip applicators. TROPICAMIDE Rivex Ophthalmics Mydriatic–Cycloplegic

TROSYD™ AF TROSYD™ J Pfizer Consumer Tioconazole Antifungal Agent Action and Clinical Tioconazole is a member of the imidazole class of antifungal agents. Although the mode of action of tioconazole has not as yet been determined, several studies have demonstrated that the imidazoles inhibit ergosterol synthesis in fungi by blocking C-14 demethylation. As a result, there is an accumulation of C-14 methyl sterol intermediates like langosterol, and a decrease in…

TRUSOPT® Merck Frosst Dorzolamide HCl Elevated Intraocular Pressure Therapy–Topical Carbonic Anhydrase Inhibitor Action and Clinical Dorzolamide is a carbonic anhydrase inhibitor formulated for topical ophthalmic use. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure (IOP). Unlike oral carbonic anhydrase…

TRYPTAN™ ICN L-Tryptophan Adjunct in the Management of Affective Disorders Action and Clinical The rationale for the use of L-tryptophan in affective disorders is based on clinical findings more than 20 years ago, that L-tryptophan increases 5-HT (serotonin) synthesis in the CNS of humans. It has been demonstrated in clinical trials that oral ingestion of L-tryptophan in humans caused a significant increase in the level of the serotonin metabolite, 5-hydroxyindoleacetic…

TRIPTIL® Merck Frosst Protriptyline HCl Antidepressant Indications And Clinical Uses: In the treatment of depression that is a manifestation of psychosis or neurosis, whether endogenous or reactive in nature. Endogenous depression is more likely to respond than other depressive states. It is especially recommended for apathetic, withdrawn patients because it promptly relieves anergia and lacks sedative activity. These qualities make it useful also in ambulatory depressed patients. When used in…

TRISORALEN™ ICN Trioxsalen Melanizing Agent Action And Clinical Pharmacology: Trioxsalen is a synthetic melanizing agent structurally and pharmacologically related to methoxsalen. The normal pigmentation of the skin is due to melanin, which is produced in the cytoplasm of the melanocytes located in the basal layers of the epidermis at its junction with the dermis. Melanin is formed by the oxidation of tyrosine to DOPA (dihydroxyphenylalanine) with tyrosinase as catalyst. This…

TRISULFAMINIC Shepherd Triple Sulfas–Phenylpropanolamine HCl Compound–Pheniramine Maleate Decongestant–Antibacterial Indications And Clinical Uses: Congestion and infection of upper respiratory tract caused by sulfa-susceptible organisms. Contra-Indications: Sensitivity to any of the components, impaired renal function, pregnancy approaching term, and in premature infants and newborn infants during the first month of life. Do not use in patients with glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal or bladder neck obstruction or patients receiving MAO…

TROMBOVAR® Therapex Sodium Tetradecyl Sulfate Sclerosing Agent Indications And Clinical Uses: Sclerosing treatment of varicose veins in the legs, using compression sclerotherapy. Contra-Indications: Incompetency of collateral deep veins in the legs; incompetency of the valves of the greater and lesser saphenous veins before ligation of those veins; thrombophlebitis, tuberculosis and hyperthyroidism, acute infections, prolonged recumbency; cardiac insufficiency, diabetes, arterial disease, varicosities caused by pelvic neoplasia, pregnancy. Hypersensitivity to sodium tetradecyl…