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FUCIDIN® Tablets FUCIDIN® I.V. FUCIDIN® Suspension Leo Sodium Fusidate Fusidic Acid Antibiotic Action And Clinical Pharmacology: The antibacterial action of fusidic acid results from the inhibition of bacterial protein synthesis. The drug interferes with amino acid transfer from aminoacyl-sRNA to protein on the ribosomes. Fusidic acid may be bacteriostatic or bactericidal depending on inoculum size. Although bacterial cells stop dividing almost within 2 minutes after contact with the antibiotic in…

FROBEN® FROBEN SR® Knoll Flurbiprofen Nonsteroidal Anti-inflammatory Agent Action And Clinical Pharmacology: Flurbiprofen is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic activity. Although its mechanism of action has not been completely elucidated it has been shown to be an inhibitor of prostaglandin synthesis, specifically cyclo-oxygenase, and to some extent lipoxygenase, and is not due to pituitary-adrenal stimulation. Flurbiprofen is well absorbed and the rate of absorption is not altered…

FULVICIN® P/G Schering Griseofulvin (Ultramicrosize) Antifungal Antibiotic Indications And Clinical Uses: For the treatment of ringworm infections of the skin, hair and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, tinea capitis, tinea unguium (onychomycosis) when caused by susceptible strains of the following genera of fungi: T. rubrum, T. tonsurans, T. mentagrophytes, T. interdigitale, T. verrucosum, T. sulphureum, T. schoenleinii, T. megninii, T. gallinae, T. crateriform, M. audouini,…

FUCIDIN® Cream FUCIDIN® Ointment FUCIDIN® Intertulle Leo Fusidic Acid Sodium Fusidate Antibiotic Action And Clinical Pharmacology: Fusidic acid inhibits bacterial protein synthesis by interfering with amino acid transfer from aminoacyl-sRNA to protein on the ribosomes. Fusidic acid may be bacteriostatic or bactericidal depending on inoculum size. Although bacterial cells stop dividing almost within 2 minutes after contact with the antibiotic in vitro, DNA and RNA synthesis continue for 45 minutes…

FRISIUM® Hoechst Marion Roussel Clobazam Anticonvulsant for Adjunctive Therapy Action And Clinical Pharmacology: Clobazam is a 1,5-benzodiazepine with anticonvulsant properties. In general, the mode of antiepileptic action of clobazam is probably largely analogous to that of the 1,4-benzodiazepines . The differences between clobazam (a 1,5-benzodiazepine) and the 1,4-benzodiazepines in terms of therapeutic efficacy and neurotoxicity are possibly due to the variation in degree of the agonist action at the high…

FRAXIPARINE™ Sanofi Nadroparin Calcium Anticoagulant – Antithrombotic Action And Clinical Pharmacology: Nadroparin is a low molecular weight heparin. It is a heterogeneous mixture of sulfated polysaccharide glycosaminoglycan chains obtained by depolymerisation of porcine mucosal sodium heparin, extraction/purification and conversion to the calcium salt. Of the low molecular weight heparins, nadroparin has the lowest mean molecular weight of approximately 4 300 daltons; 75 to 95% of the molecular masses are in…

FOSAMAX® MSD Alendronate Sodium Bone Metabolism Regulator Action And Clinical Pharmacology: Alendronate is an aminobisphosphonate that acts as a potent, specific inhibitor of osteoclast-mediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone. Pharmacokinetics: Absorption: Relative to an i.v. reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an…

FORTAZ® Glaxo Wellcome Ceftazidime Pentahydrate Antibiotic Action And Clinical Pharmacology: In vitro studies indicate that the bactericidal action of ceftazidime, a semisynthetic cephalosporin antibiotic, results from inhibition of bacterial cell wall synthesis. Ceftazidime has a high affinity for the Penicillin-Binding Protein-3 (PBP-3) and moderate affinity for the PBP-1a of certain gram-negative organisms such as E. coli and P. aeruginosa. The affinity for PBP-1b is much less than that for either…

FRAGMIN® Pharmacia & Upjohn Dalteparin Sodium Anticoagulant – Antithrombotic Action And Clinical Pharmacology: Dalteparin is an antithrombotic agent. Dalteparin sodium (low molecular weight heparin sodium) has an average molecular weight of 5 000. Dalteparin is produced through controlled nitrous acid de-polymerization of sodium heparin from porcine intestinal mucosa. It is composed of strongly acidic sulfated polysaccharide chains with an average molecular weight of 5 000 and about 90% of the…

FOLLOW-UP SOY® Nestl©, Carnation Soy Infant Formula Indications And Clinical Uses: A soy based, iron fortified formula designed to meet the nutritional needs of babies from 6 to 12 months of age who are already eating baby foods. Follow-Up soy formula is designed to be the liquid portion of a 6 to 12 month old baby’s diet. It is a nutritionally superior formula for milk-free feeding for babies 6 to…