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LIDOSPORIN® Cream LIDOSPORIN® Ear Drops Warner-Lambert Consumer Healthcare Polymyxin B Sulfate – Gramicidin – Lidocaine HCl Polymyxin B Sulfate – Lidocaine HCl Antibiotic – Anesthetic – Antipruritic Indications And Clinical Uses: Cream: Topical relief of pain and itching; also for the treatment and prevention of infections in minor cuts, wounds, and burns. Ear Drops: The prevention of exacerbations and treatment of infection due to susceptible organisms, relief of pain and…

LINCOCIN® Pharmacia & Upjohn Lincomycin HCl Monohydrate Antibiotic Action And Clinical Pharmacology: The mode of action of lincomycin is the inhibition of protein synthesis by the inhibition of the binding of aminoacyl sRNA to the messenger ribosome complex at the 50S ribosomal unit. Lincomycin is absorbed rapidly after oral administration, reaching peak levels in 2 to 4 hours. Levels above the minimum inhibitory concentration for most gram-positive organisms are maintained…

LIORESAL® Novartis Pharmaceuticals Baclofen Muscle Relaxant – Antispastic Action And Clinical Pharmacology: Baclofen’s precise mechanisms of action are not fully known. It inhibits both monosynaptic and polysynaptic reflexes at the spinal level, probably by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect. Although baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence…

LIORESAL® Intrathecal Novartis Pharmaceuticals Baclofen Muscle Relaxant – Antispastic Action And Clinical Pharmacology: The precise mechanisms of action of baclofen as a muscle relaxant and antispastic agent are not fully understood. Baclofen inhibits both monosynaptic and polysynaptic reflex transmission at the spinal level, possibly by decreasing excitatory neurotransmitter release from primary afferent terminals. Actions at supraspinal sites may also contribute to its clinical effect. Baclofen is an analogue of the…

LIDEMOL® Medicis Fluocinonide Topical Corticosteroid Indications And Clinical Uses: For topical therapy of corticosteroid-responsive acute and chronic skin eruptions where an anti-inflammatory, anti-allergenic and antipruritic activity in the topical management is required. Contra-Indications: Untreated bacterial, tubercular, fungal and most viral lesions of the skin (including herpes simplex, vaccinia and varicella) and untreated purulent bacterial infections. Hypersensitivity to any of the components. Manufacturers’ Warnings In Clinical States: Pregnancy and Lactation: The…

LIDEX® Medicis Fluocinonide Topical Corticosteroid Indications And Clinical Uses: For topical therapy of corticosteroid-responsive acute and chronic skin eruptions where an anti-inflammatory, anti-allergenic and antipruritic activity in the topical management is required. Contra-Indications: Untreated bacterial, tubercular, fungal and most viral lesions of the skin (including herpes simplex, vaccinia and varicella). Contraindicated in individuals with a history of hypersensitivity to any of the components. Manufacturers’ Warnings In Clinical States: Pregnancy and…

LEVOTEC Technilab Levothyroxine Sodium Hypothyroidism Therapy Action And Clinical Pharmacology: Levothyroxine sodium is the monosodium salt of the levorotatory isomer of thyroxin (tetraiodothyronine), the principal hormone secreted by the normal thyroid gland. Following oral administration, the absorption of levothyroxine is incomplete and variable (50 to 75%), especially when taken with food. Once absorbed, synthetic levothyroxine is indistinguishable from the endogenous hormone. Levothyroxine is nearly totally bound to serum proteins and…

LEVOPHED® Sanofi Norepinephrine Bitartrate Sympathomimetic Action And Clinical Pharmacology: Norepinephrine functions as a powerful peripheral vasoconstrictor (alpha-adrenergic action) and as a potent inotropic stimulator of the heart and dilator of coronary arteries (beta-adrenergic action). Both of these actions result in an increase in systemic blood pressure and coronary artery blood flow. Cardiac output will vary reflexly in response to systemic hypertension but is usually increased in hypotensive man when the…

LEVSIN® Rivex Pharma Hyoscyamine Sulfate Antispasmodic Action And Clinical Pharmacology: Hyoscyamine inhibits specifically the actions of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These peripheral cholinergic receptors are present in the autonomic effector cells of the smooth muscle, cardiac muscle, the sinoatrial node, the atrioventricular node, and the exocrine glands. It is completely devoid of any action…

LEVOVIST® Berlex Canada Galactose – Palmitic Acid Ultrasound Contrast Agent Action And Clinical Pharmacology: Levovist is an ultrasound contrast agent consisting of granules which are composed of 99.9% galactose and 0.1% palmitic acid. Prior to use, Levovist must be reconstituted with sterilized water for injections and shaken vigorously by hand for 5 to 10 seconds. After injection of the suspension into a peripheral vein, Levovist leads to temporarily enhanced ultrasound…