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CEREBYX® Parke-Davis Fosphenytoin Sodium Antiepileptic Action And Clinical Pharmacology: Introduction: Following parenteral administration of fosphenytoin, fosphenytoin is converted to the anticonvulsant phenytoin. For every mmol of fosphenytoin administered, 1 mmol of phenytoin is produced. The pharmacological and toxicological effects of fosphenytoin include those of phenytoin. However, the hydrolysis of fosphenytoin to phenytoin yields 2 metabolites, phosphate and formaldehyde. Formaldehyde is subsequently converted to formate, which is in turn metabolized via…

CERUBIDINE® Rh´ne-Poulenc Rorer Daunorubicin Antimitotic – Antibiotic Action And Clinical Pharmacology: Daunorubicin inhibits the synthesis of nucleic acids; its effect on desoxyribonucleic acid is particularly rapid and marked. Ribonucleic acid is more gradually affected. It appears that the action of the drug is the result of the formation of a complex with desoxyribonucleic acid in the cell nucleus; this blocks the site of action of the polymerases and gives daunorubicin…

CERUMENEX® Purdue Frederick Triethanolamine Polypeptide Oleate-condensate Cerumenolytic Indications And Clinical Uses: For removal of impacted cerumen. Cleansing prior to aural examination, treatment, or audiometry. Should not be used for routine wax removal or cleaning of the ears. Contra-Indications: Perforated eardrum. Middle ear infection or severe inflammatory or atopic dermatitis in the external ear. Positive patch test. History of untoward reaction to Cerumenex. Precautions: Should be used with extreme caution in…

CELESTONE® SOLUSPAN ® Schering Betamethasone Sodium Phosphate – Betamethasone Acetate Injectable Glucocorticoid Indications And Clinical Uses: (1) I.M. injection in allergic, dermatologic, rheumatic, and other conditions responsive to systemic corticosteroids, including bursitis; (2) injection directly into the affected tissues in bursitis and associated inflammatory disorders of tendons such as tenosynovitis, and inflammatory disorders of muscle such as fibrositis and myositis; (3) intra-articular and periarticular injection in rheumatoid arthritis and osteoarthritis;…

CellCept® Roche Mycophenolate Mofetil Immunosuppressant Agent Manufacturers’ Warnings In Clinical States: Increased susceptibility to infection and the possible development of lymphoma may result from immunosuppression. Only physicians experienced in immunosuppressive therapy and management of solid organ transplant patients should use mycophenolate mofetil. Patients receiving the drug should be managed in facilities equipped and staffed with adequate laboratory and supportive medical resources. The physician responsible for maintenance therapy should have complete…

CELONTIN® Parke-Davis Methsuximide Anticonvulsant Action And Clinical Pharmacology: Methsuximide elevates seizure threshold in the cortex and basal ganglia and reduces synaptic response to low frequency repetitive stimulation. The peroxisomal spike and wave pattern of the EEG, common in petit mal seizure, is suppressed. Pharmacokinetics: Methsuximide is absorbed from the gastrointestinal tract and peak plasma levels are achieved in 1 to 3 hours. The plasma half-life of methsuximide is slightly less…

CENTRUM® CENTRUM® FORTE CENTRUM® PROTEGRA CENTRUM® SELECT Whitehall-Robins Multiple Vitamins – Minerals Vitamin-Mineral Supplement Indications And Clinical Uses: For use as a nutritional supplement. Contra-Indications: In the presence of hemochromatosis, hemosiderosis, hemolytic anemia. Precautions: Oral iron preparations may aggravate existing peptic ulcer, regional enteritis and ulcerative colitis. Oral iron preparations can impair the absorption of tetracycline antibiotics. Antacids given concomitantly with iron compounds decrease iron absorption. Adverse Reactions: Rarely, in…

CEFTIN® Glaxo Wellcome Cefuroxime Axetil Antibiotic Action And Clinical Pharmacology: Cefuroxime axetil is an orally active prodrug of cefuroxime. After oral administration, cefuroxime axetil is absorbed from the gastrointestinal tract and rapidly hydrolyzed by nonspecific esterases in the intestinal mucosa and blood to release cefuroxime into the blood stream. Conversion to cefuroxime, the microbiologically active form, occurs rapidly. The inherent properties of cefuroxime are unaltered after its administration as cefuroxime…

CEFZIL™ Bristol-Myers Squibb Cefprozil Antibiotic Action And Clinical Pharmacology: Cefprozil is a semisynthetic broad spectrum cephalosporin antibiotic intended for oral administration. It has in vitro activity against a broad range of gram positive and gram negative bacteria. The bactericidal action of cefprozil results from inhibition of cell-wall synthesis. Pharmacokinetics: Cefprozil is well absorbed following oral administration in both fasting and nonfasting subjects. The oral bioavailability of cefprozil is about 90%….

CELESTODERM®-V CELESTODERM®-V/2 Schering Betamethasone Valerate Topical Corticosteroid Indications And Clinical Uses: The topical management of allergic and inflammatory dermatoses responsive to corticosteroid therapy, such as psoriasis, atopic eczema, infantile eczema, nummular eczema, pruritus ani and vulvae, neurodermatitis (lichen simplex chronicus), intertrigo, contact dermatitis, seborrheic dermatitis, exfoliative dermatitis, solar dermatitis, stasis dermatitis and dyshidrosis. Refractory psoriasis may be treated with Celestoderm-V especially in conjunction with the hydration technique of occlusive dressings….