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CHRONOVERA® Searle Verapamil HCl Antihypertensive – Antianginal Agent System Components and Performance: Chronovera is a formulation designed to initiate the release of verapamil approximately 4 to 5 hours after ingestion by means of a delay coating and thereafter to provide a constant rate of release over 12 hours. The tablet is comprised of a semipermeable membrane surrounding a drug core that is osmotically active. The core itself is divided into…

CICATRIN® Glaxo Wellcome Bacitracin – Neomycin Sulfate – Amino Acids Antibiotic – Tissue Healant Indications And Clinical Uses: As a prophylactic or treatment and healing agent for surface wounds, minor burns, and stasis ulcers. Not recommended for the treatment of superficial fungal infections. The use of the powder does not exclude concomitant systemic therapy with antibiotics where appropriate. Contra-Indications: Patients who have demonstrated allergic hypersensitivity to the product or any…

CHOLEDYL® SA Parke-Davis Oxtriphylline Bronchodilator Action And Clinical Pharmacology: Oxtriphylline is the theophylline salt of choline and contains 64% theophylline with the properties attributed to it. Choledyl SA is a sustained release tablet which produces peak blood levels of theophylline (8 to 12 g/mL) between 2 and 4 hours. Once the steady-state level has been reached, the therapeutic blood levels persist for 12 hours. Indications And Clinical Uses: For maintenance…

CHOLERA VACCINE Connaught Cholera Prophylaxis Indications And Clinical Uses: For immunization against cholera. Precautions: As with any injection of biological materials, epinephrine HCl solution (1:1 000) should be immediately available as a precautionary measure should an acute anaphylactoid reaction occur. Adverse Reactions: Vaccination often results in discomfort at the site of injection for 1 or more days. The local reaction may be accompanied by fever, malaise and headache. Dosage And…

CHOLOXIN® Knoll hyper Hypolipidemic Thyroactive Agent Action And Clinical Pharmacology: Dextrothyroxine reduces serum cholesterol levels in hyperlipidemic patients. Beta lipoprotein and triglyceride fractions may also be reduced from previously elevated levels. Dextrothyroxine stimulates the liver to increase catabolism and excretion of cholesterol and its degradation products via the biliary route into the feces. Cholesterol synthesis is not inhibited and abnormal metabolic end-products do not accumulate in the blood. Indications And…

CHOLECYSTOKININ Ferring Diagnostic Cholecystokinetic Action And Clinical Pharmacology: Cholecystokinin (CCK) is a natural polypeptide, formed in the APUD cells of the proximal mucosa of the small intestine. It stimulates secretion of pancreatic digestive enzymes, the flow of bile and the secretion from the glands of Brunner. It stimulates contraction of the gallbladder, inhibits contraction of the lower esophageal sphincter and the sphincter of Oddi and increases motility of the stomach…

CHLORPROMAZINE General Monograph, Antipsychotic – Antiemetic Pharmacology: Chlorpromazine is an aliphatic phenothiazine. Phenothiazines are thought to elicit their antipsychotic and antiemetic effects via interference with central dopaminergic pathways in the mesolimbic and medullary chemoreceptor trigger zone areas of the brain, respectively. Extrapyramidal side effects are a result of interaction with dopaminergic pathways in the basal ganglia. Although often termed dopamine blockers, the exact mechanism of dopaminergic interference responsible for the…

CHOLEDYL® EXPECTORANT Parke-Davis Oxtriphylline – Guaifenesin Bronchodilator – Expectorant Action And Clinical Pharmacology: Oxtriphylline contains 64% theophylline and has the properties attributed to theophylline. tag_IndicationsIndications Indications And Clinical Uses: The symptomatic treatment of reversible bronchoconstriction associated with chronic obstructive pulmonary emphysema, bronchial asthma, chronic bronchitis and related bronchospastic disorders and where expectoration is required. Precautions: Patients starting therapy should be carefully observed to determine if this fixed dose combination is…

CHOLEDYL® Parke-Davis Oxtriphylline Bronchodilator Action And Clinical Pharmacology: Oxtriphylline contains 64% theophylline and has the properties attributed to theophylline. Indications And Clinical Uses: The symptomatic treatment of reversible bronchoconstriction associated with bronchial asthma, chronic obstructive pulmonary emphysema, chronic bronchitis and related bronchospastic disorders. Contra-Indications: Hypersensitivity to xanthines; active peptic ulcer; in coronary artery disease when myocardial stimulation might prove harmful. Precautions: Parents should be cautioned against overdosage to children –…

CHLORAMPHENICOL General Monograph, Antibiotic Pharmacology: Chloramphenicol, which was originally isolated from Streptomyces venezuelae and is now synthetically produced, exerts mainly a bacteriostatic effect on a wide range of gram-positive and gram-negative organisms and is active against Rickettsia, Chlamydia (psittacosis-lymphogranuloma organisms), and Mycoplasma. It is particularly effective against H. influenzae, S. pneumoniae, S. typhi and Neisseria species. The palmitate and sodium succinate esters are inactive until hydrolyzed to free chloramphenicol which…