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DICETEL® Solvay Pharma Pinaverium Bromide Gastrointestinal Calcium Antagonist Action And Clinical Pharmacology: Pinaverium is a calcium antagonist which inhibits the calcium influx by blocking the voltage-dependent calcium channel at the smooth muscle cell level. It possesses a high degree of selectivity for the intestinal smooth muscle. Many studies showed that pinaverium induces a relaxation of the gastrointestinal and the biliary tracts and mainly of the colon, an inhibition of the…

DICLECTIN® Duchesnay Doxylamine Succinate – Pyridoxine HCl Antinauseant against Nausea and Vomiting of Pregnancy Action And Clinical Pharmacology: The action of Diclectin is due to 2 unrelated compounds. Doxylamine succinate, an antihistamine, provides the antinauseant and antiemetic activity; pyridoxine HCl provides a supplement of vitamin B6 to prevent a possible pyridoxine deficiency during pregnancy. Also, studies have shown that pyridoxine itself could have an antinauseant activity. The onset of the…

DICLOTEC Technilab Diclofenac Sodium Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Diclofenac sodium is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. The mode of action is not fully known but it does not act through the pituitary-adrenal axis. Diclofenac sodium inhibits prostaglandin synthesis by interfering with the action of prostaglandin synthetase. This inhibitory effect may partially explain its actions. From a clinical efficacy standpoint, diclofenac sodium 75…

DIAMICRON® Servier Gliclazide Oral Hypoglycemic Action And Clinical Pharmacology: Gliclazide is an hypoglycemic agent of the sulfonylurea group. Its hypoglycemic action is related to an improvement in insulin secretion from the functioning beta cells of the pancreas. It potentiates the insulin release and improves the dynamics of insulin. Hemobiological properties of gliclazide have been observed in pharmacology studies. These are attributed to gliclazide action on the platelet behavior, prostaglandin equilibrium…

DIANE®-35 Berlex Canada Cyproterone Acetate – Ethinyl Estradiol Acne Therapy Action And Clinical Pharmacology: Diane-35 is a combination antiandrogen-estrogen for use in the treatment of androgen-dependent dermatological conditions in females. Cyproterone is a steroid compound with potent antiandrogenic, progestogenic and antigonadotrophic activity. It exerts its antiandrogenic effect by blocking androgen receptors. It also reduces androgen synthesis by a negative feedback effect on the hypothalamo-pituitary-ovarian systems. The estrogen component (ethinyl estradiol)…

DIAZEMULS® Pharmacia & Upjohn Diazepam Injectable Emulsion Anxiolytic – Sedative Action And Clinical Pharmacology: Diazemuls is an injectable emulsion of diazepam, a drug with known anxiolytic-sedative and muscle relaxant properties. Diazepam has been found useful for short-term symptomatic relief of excessive anxiety and tension in patients with anxiety neurosis, although anxiety and tension associated with the stresses of everyday life usually do not require treatment with anxiolytic drugs. Diazepam must…

DESYREL® DESYREL® DIVIDOSE Bristol Trazodone HCl Antidepressant Action And Clinical Pharmacology: Trazodone is a psychoactive compound with sedative and antidepressant properties. Its mechanism of action in humans is not clear. Trazodone is well absorbed after oral administration with peak plasma levels obtained within 0.5 to 2 hours after ingestion. Absorption is somewhat delayed and enhanced by food. The mean plasma elimination half-life is 4.4 hours for the period from 3…

DIABINESE™ Pfizer Chlorpropamide Oral Hypoglycemic Action And Clinical Pharmacology: Chlorpropamide is an orally active hypoglycemic agent which reduces blood sugar concentration without affecting glucose tolerance. It probably acts by stimulating insulin secretion in the presence of functioning pancreatic islet tissue. Chlorpropamide is absorbed readily from the gastrointestinal tract and is bound to plasma proteins. Within 1 hour after a single oral dose, it is detectable in the blood, and the…

DESOCORT® Galderma Desonide Topical Corticosteroid Action And Clinical Pharmacology: Desonide, like all topical corticosteroids, exhibits anti-inflammatory, antipruritic and vasoconstrictive actions. tag_IndicationsIndications Indications And Clinical Uses: For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Contra-Indications: Tuberculous, fungal and most viral lesions of the skin (including herpes simplex, vaccinia and varicella). Hypersensitivity to any of the components. Not for ophthalmic use. Precautions: General: Systemic absorption of topical corticosteroids…

DEPROIC® Technilab Valproic Acid Anticonvulsant Action And Clinical Pharmacology: Valproic acid exhibits anticonvulsant properties. While the exact mechanism of action is unknown, several investigators have proposed that the anticonvulsive effect of valproic acid can be related to increased gamma-amino-butyric acid (GABA) levels in the brain. The effect on the neuronal membrane is unknown. After oral administration, valproic acid is rapidly absorbed, reaching peak serum levels within 1 to 4 hours….