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HEPARINS: LOW MOLECULAR WEIGHT General Monograph, Dalteparin Enoxaparin Nadroparin Tinzaparin Anticoagulant Action And Clinical Pharmacology: Low molecular weight heparins (LMWHs) are fragments of heparin produced by enzymatic or chemical depolymerization. They have an average molecular weight of 4 000 to 5 000 daltons (range 1 000 to 10 000 daltons) which is approximately one-third that of standard heparin. Most heparin molecules with molecular weights smaller than 5 400 daltons are…

HALOG® Preparations Westwood-Squibb Halcinonide Topical Corticosteroid Indications And Clinical Uses: Halcinonide, a synthetic fluorinated corticosteroid, is indicated for topical application for the relief of the inflammatory manifestations of acute or chronic corticosteroid responsive dermatoses; under occlusion, in the management of recalcitrant cases of psoriasis and neurodermatitis. Contra-Indications: Tuberculous, fungal and most viral lesions of the skin (including herpes simplex, vaccinia, and varicella). Patients with history of hypersensitivity to any of…

HAVRIX™ SmithKline Beecham Hepatitis A Vaccine (Inactivated) Active Immunization Agent against infection by Hepatitis A virus Action And Clinical Pharmacology: Hepatitis A vaccine (inactivated) confers immunity against hepatitis A virus (HAV) infection by inducing the production of specific anti-HAV antibodies. In clinical studies involving subjects of 18 to 50 years of age, specific humoral antibodies against HAV were detected in more than 88% of vaccinees at day 15 and 99%…

HABITROL® Novartis Consumer Health Nicotine Smoking Cessation Aid Action And Clinical Pharmacology: Habitrol delivers S(-)-nicotine, the active component of tobacco smoke, transdermally into the systemic circulation, continuously over 24 hours. Habitrol releases S(-)-nicotine in controlled amounts at a rate sufficient to produce plasma nicotine concentrations comparable to trough levels observed in smokers before smoking a cigarette. Because of the low, continuous delivery of S(-)-nicotine through the skin, Habitrol does not…

HALCION® Pharmacia & Upjohn Triazolam Hypnotic Action And Clinical Pharmacology: Triazolam is a benzodiazepine hypnotic with a very short elimination half-life (about 3 hours). In sleep laboratory studies of 1 to 21 days duration, triazolam significantly decreased sleep latency, increased duration of sleep and decreased the number of nocturnal awakenings. However, after 2 weeks of consecutive nightly administration, the drug’s effect on total wake time was decreased, and the values…

HALDOL® LA Janssen-Ortho Haloperidol Decanoate Antipsychotic Action And Clinical Pharmacology: Haloperidol decanoate, an ester derivative of haloperidol obtained from condensation of haloperidol with decanoic acid possesses the antipsychotic properties of haloperidol. When it is administered as an i.m. depot in sesame oil, esterases present in blood and tissues hydrolyze haloperidol decanoate to provide a slow release of the active neuroleptic haloperidol from the depot into the systemic circulation. The onset…

GUAIFENESIN General Monograph Glyceryl Guaiacolate Expectorant Pharmacology: Guaifenesin is believed to produce its effect through a local or reflex irritant action that activates the vagus nerve to stimulate secretion or respiratory tract fluid. This is thought to increase sputum volume, decrease its viscosity, enhance the flow of less viscid secretions and promote mucociliary clearance. Pharmacokinetics: The drug is rapidly absorbed from the gastrointestinal tract and excreted in the urine. Indications:…

GYNECURE™ Pfizer Consumer Tioconazole Antifungal Agent Action And Clinical Pharmacology: Tioconazole is a member of the imidazole class of antifungal agents. Although the mode of action of tioconazole has not as yet been determined, several studies have demonstrated that the imidazoles inhibit ergosterol synthesis in fungi by blocking C-14 demethylation. As a result, there is an accumulation of C-14 methyl sterol intermediates like langosterol, and a decrease in ergosterol. Langosterol…

GYNE-T® 380 Slimline Intrauterine Copper Contraceptive Janssen-Ortho Intrauterine Copper Contraceptive Intrauterine Contraception Description: The intrauterine device consists of a polyethylene support in the shape of a “T”. The horizontal arm is 32 mm in length and 1.59 mm in diameter. The vertical arm is 36 mm in length and 1.52 mm in diameter. The vertical arm has at its tip a spherical enlargement, 0.3 mm in diameter. The “T” carries…

GRAVERGOL® Carter Horner Ergotamine Tartrate – Caffeine – Dimenhydrinate Migraine Therapy Indications And Clinical Uses: For the relief of migraine headaches and other recurrent vascular headaches as well as nausea, vomiting and dizziness that accompany the attacks. Contra-Indications: Sepsis, occlusive vascular disease (thromboangiitis obliterans, luetic arteritis, severe arteriosclerosis, coronary artery disease, thrombophlebitis, Raynaud’s disease), hepatic disease, renal disease, hypertension, angina pectoris, peptic ulcer, infectious states, malnutrition, severe pruritus, pregnancy, lactation….