Ergotamine Tartrate – Caffeine – Dimenhydrinate
Indications And Clinical Uses: For the relief of migraine headaches and other recurrent vascular headaches as well as nausea, vomiting and dizziness that accompany the attacks.
Contra-Indications: Sepsis, occlusive vascular disease (thromboangiitis obliterans, luetic arteritis, severe arteriosclerosis, coronary artery disease, thrombophlebitis, Raynaud’s disease), hepatic disease, renal disease, hypertension, angina pectoris, peptic ulcer, infectious states, malnutrition, severe pruritus, pregnancy, lactation. Hypersensitivity to any of the components.
Precautions: Use cautiously in debilitated or anemic patients and in thyrotoxicosis. Discontinue therapy if patient reports cold, numbness, pain in extremities or muscle cramps.
Occupational Hazards: If medication causes drowsiness, avoid activities requiring alertness.
See also Gravol Preparations monograph.
There is some evidence that the concomitant use of triacetyloleandomycin (TAO/troleandomycin) and ergotamine may give rise to untoward peripheral vasoconstriction.
Symptoms And Treatment Of Overdose: Ergotamine might produce peripheral vascular complications, precordial distress and pain, transient tachycardia or bradycardia. See also Overdose section of Gravol Preparations monograph.Symptoms: Theoretically, toxicity could be caused by either dimenhydrinate or ergotamine tartrate. These agents could produce vomiting, diarrhea, dizziness, weak pulse, convulsions, dyspnea and coma.
Treatment: No specific or known antidote. Employ general measures and treat convulsions, if necessary.
Dosage And Administration: 2 capsules at very first sign of attack, then 1 capsule at 0.5 hour intervals if required. Maximum dose for any single attack: 6 capsules. Maximum weekly dose: 12 capsules.
Note: The total number of capsules required to relieve an attack should be noted and taken as a single dose for future attacks.
Availability And Storage: Each dark green, No. 1 hard gelatin capsule of pink powder, contains: ergotamine tartrate 1 mg, caffeine 100 mg and dimenhydrinate 50 mg. Nonmedicinal ingredients: alumina, D&C Yellow No. 10, FD&C Red No. 3 and Green No. 3, gelatin, lactose and magnesium stearate. Energy: 5.7 kJ (1.35 kcal)/capsule. Alcohol-, gluten- and tartrazine-free. Bottles of 20 and 100. (Shown in Product Recognition Section)
GRAVERGOL® Carter Horner Ergotamine Tartrate – Caffeine – Dimenhydrinate Migraine Therapy