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LAMICTAL® Glaxo Wellcome Lamotrigine Antiepileptic Action And Clinical Pharmacology: Lamotrigine is a drug of the phenyltriazine class chemically unrelated to existing antiepileptic drugs (AEDs). Lamotrigine is thought to act at voltage-sensitive sodium channels to stabilize neuronal membranes and inhibit the release of excitatory amino acid neurotransmitters (e.g. glutamate, aspartate) that are thought to play a role in the generation and spread of epileptic seizures. Clinical Trials: In placebo-controlled clinical studies,…

JECTOFER® Astra Iron-Sorbitol-Citric Acid Complex, Dextrin-Stabilized Intramuscular Hematinic Action And Clinical Pharmacology: Many of the properties of iron sorbitol result from its relatively low molecular weight. It is rapidly absorbed from the injection site and is stable in tissue fluids. Two-thirds of the injected dose is absorbed from an i.m. site within 3 hours, most of it directly into the blood circulation and, to a lesser extent, via lymphatics. Within…

LAC-HYDRIN® Westwood-Squibb Ammonium Lactate Moisturizer Indications And Clinical Uses: For the treatment of moderate to severe dry skin and scaling (xerosis), and hyperkeratotic conditions such as ichthyosis, and for the temporary relief of itching associated with these conditions. Contra-Indications: Abraded or inflamed skin. Known sensitivity to any of the ingredients. Precautions: If irritation develops, use should be discontinued. For external use only. Dosage: Apply to the affected areas twice daily…

ISOSOURCE® HN Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A high nitrogen, complete liquid tube feeding (nasogastric, nasoduodenal or jejunal) for patients with normal gastrointestinal function, when low-residue feeding is required. Because it is slightly flavored, Isosource HN may be appropriate for oral administration in patients experiencing altered or heightened taste perceptions (e.g., individuals undergoing radiation and chemotherapy treatment). Precautions: Not for parenteral administration. Dosage And Administration: 1 500…

ISUPREL® Sanofi Isoproterenol HCl Sympathomimetic Indications And Clinical Uses: Inhalation solution: Symptomatic relief of bronchial asthma and in cases of emphysema, bronchitis and other chronic bronchopulmonary disorders in which bronchospasm is a complicating factor. Injectable form is particularly suitable for the treatment and prevention of (1) Adams-Stokes syndrome and other episodes of heart block, except when caused by ventricular tachycardia or fibrillation (2) cardiac arrest (3) mild or transient episodes…

ISOPTIN® Knoll Verapamil HCl Antianginal – Antiarrhythmic – Antihypertensive Agent Action And Clinical Pharmacology: Angina and Arrhythmia: Verapamil is a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist). The mechanism of the antianginal and antiarrhythmic effects of verapamil is believed to be related to its specific cellular action of selectively inhibiting transmembrane influx of calcium in cardiac muscle, coronary and systemic arteries and in cells of the…

ISOSOURCE® HN Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A high nitrogen, complete liquid tube feeding (nasogastric, nasoduodenal or jejunal) for patients with normal gastrointestinal function, when low-residue feeding is required. Because it is slightly flavored, Isosource HN may be appropriate for oral administration in patients experiencing altered or heightened taste perceptions (e.g., individuals undergoing radiation and chemotherapy treatment). Precautions: Not for parenteral administration. Dosage And Administration: 1 500…

ISOSOURCE® VHN Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A high nitrogen, fibre containing, complete liquid tube feeding (nasogastric, nasoduodenal or jejunal) for patients with normal gastrointestinal function. Recommended for both short-term and long-term feeding. Not recommended when a low residue tube feeding is required. Precautions: Not for parenteral administration. Dosage And Administration: 1 250 mL or 5 220 kJ (5 cans or 1 250 kcal) provides at least…

ISONIAZID General Monograph, INH Isonicotinic Acid Hydrazide Isonicotinylhydrazide Antimycobacterial Pharmacology: Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically M. tuberculosis, M. bovis and M. kansasii. It is a highly specific agent, ineffective against other microorganisms. The mode of action is unknown but the drug is firmly bound to actively growing, sensitive, tubercle bacilli and does not affect these organisms when they are in the metabolic…

ISOPTIN® I.V. Knoll Verapamil HCl Antiarrhythmic Action And Clinical Pharmacology: Mode of Action: The mechanism of action of verapamil is believed to be related to its specific cellular action of selectively inhibiting transmembrane influx of calcium in cardiac muscle, coronary and systemic arteries and in cells of the intracardiac conduction system. Verapamil blocks the transmembrane influx of calcium ion through the slow channel (calcium ion antagonism) without affecting to any…