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NASACORT™ Rhône-Poulenc Rorer Triamcinolone Acetonide Corticosteroid Action And Clinical Pharmacology: Triamcinolone is a potent anti-inflammatory steroid with strong topical and weak systemic activity. When administered intranasally in therapeutic doses, it has a direct anti-inflammatory action on the nasal mucosa, the mechanism of which is not yet completely defined. The minute amount absorbed in therapeutic doses has not been shown to exert any apparent clinical systemic effects. Indications And Clinical Uses:…

NEBCIN® Lilly Tobramycin Sulfate Antibiotic Action And Clinical Pharmacology: Like other aminoglycosides, the bactericidal activity of tobramycin is accomplished by specific inhibition of normal protein synthesis in susceptible bacteria, but at the present time, very little is known about this action. It is thought that inhibition of synthesis is due to an action on ribosomes that, in turn, causes bacterial misreading of messenger RNA. Peak serum concentrations of tobramycin occur…

NARCAN® DuPont Pharma Naloxone HCl Narcotic Antagonist Action And Clinical Pharmacology: Naloxone prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Naloxone is an essentially pure narcotic antagonist which does not possess the ‘agonistic’ or morphine-like properties characteristic of other narcotic antagonists. It does not produce respiratory depression, psychotomimetic effects or pupillary constriction. In the absence of narcotic or agonistic effects of other narcotic antagonists, it…

NASACORT® AQ Rhône-Poulenc Rorer Triamcinolone Acetonide Corticosteroid Action And Clinical Pharmacology: Triamcinolone acetonide is a potent anti-inflammatory steroid with strong topical and weak systemic activity. Triamcinolone acetonide is a more potent derivative of triamcinolone. Although triamcinolone itself is approximately 1 to 2 times as potent as prednisone in animal models of inflammation, triamcinolone acetonide is approximately 8 times more potent than prednisone. When administered intranasally in therapeutic doses, it has…

NAROPIN® Astra Ropivacaine HCl Local Anesthetic Action And Clinical Pharmacology: Mechanism of Action: Ropivacaine, a local anesthetic of the amino amide class, is supplied as the pure S-(-)-enantiomer. Ropivacaine, like other local anesthetics, causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibres. Ropivacaine has both anesthetic and analgesic effects. At high doses, surgical anesthesia…

NALCROM® Rhône-Poulenc Rorer Sodium Cromoglycate Antiallergic Agent Action And Clinical Pharmacology: Sodium cromoglycate seems to exert a stabilizing effect upon mast cells capable of releasing mediators. In gastrointestinal disease, the release of mediators causes a local inflammation which can either result in gastrointestinal symptoms or may allow absorption of antigenic material leading to systemic allergic reactions. It is most effective when given prior to antigen challenge. Sodium cromoglycate has no…

NALFON® Lilly Fenoprofen Calcium Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Fenoprofen has demonstrated anti-inflammatory, analgesic and antipyretic activities in animal studies. Although fenoprofen’s modes of action are unknown, in vitro tests have shown that it inhibits synthesis and/or release of prostaglandins; stabilizes lysosomes; inhibits platelet aggregation and platelet adhesiveness, and enhances fibrinolytic activity. All of these activities may have a role in the amelioration of inflammation, pain and fever….

MYCIFRADIN® Pharmacia & Upjohn Neomycin Sulfate Antibiotic Action And Clinical Pharmacology: Neomycin is an aminoglycoside antibiotic, active against many strains of Gram-negative bacteria. Neomycin is poorly absorbed from the normal gastrointestinal tract. The small absorbed fraction is rapidly distributed in the tissues and is excreted by the kidney in keeping with the degree of kidney function. The unabsorbed portion of the drug (approximately 97%) is eliminated unchanged in the feces….

NADOPEN-V® Nadeau Penicillin V Potassium Antibiotic Indications And Clinical Uses: Mild to moderately severe infections caused by penicillin V sensitive microorganisms including streptococcal pharyngitis, staphylococcal infection without bacteremia and pneumococcal infections. Therapy should be guided by bacteriologic sensitivity tests and clinical response. For prophylaxis following rheumatic fever and/or chorea. (Prophylaxis with oral penicillin on a continuing basis has proved effective in preventing recurrences of these conditions.) To prevent bacterial endocarditis…

MUMPSVAX® MSD Mumps Virus Vaccine, Live, Attenuated Mumps Prophylaxis Description: This vaccine is prepared from the Jeryl Lynn (B Level) strain, named after the patient from whom the virus was initially recovered. Mumpsvax is a sterile lyophilized preparation of the Jeryl Lynn (B level) strain of mumps virus. The virus was adapted to and propagated in cell cultures of chick embryo, free of avian leukosis, virus and other adventitious agents…