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NICODERM® Hoechst Marion Roussel Nicotine Smoking Cessation Aid Action And Clinical Pharmacology: Nicoderm is a multilayered rectangular film containing nicotine as the active ingredient. It provides 24 hour rate-controlled delivery of nicotine following its application to intact skin. Nicoderm reduces the withdrawal symptoms associated with smoking cessation and thus increases the success rate of smoking cessation programs. Indications And Clinical Uses: As an aid to smoking cessation for partial relief…

NETROMYCIN® Schering Netilmicin Sulfate Antibiotic Action And Clinical Pharmacology: Netilmicin is a semisynthetic, aminocyclitol, aminoglycoside antibiotic prepared from a dehydrogenated analog of gentamicin Cla. Netilmicin is a bactericidal antibiotic which acts by inhibiting normal protein synthesis in susceptible bacteria. It is thought to prevent amino acid polymerization by binding to the 30S ribosomal subunit. Netilmicin is rapidly and completely absorbed after i.m. administration. In adult subjects with normal renal function,…

NESACAINE®-CE Astra Chloroprocaine HCl Local Anesthetic Action And Clinical Pharmacology: Chloroprocaine stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses, thereby effecting local anesthetic action. The onset of action is rapid (usually within 6 to 12 minutes). The duration of anesthesia depends on the procedure and the amount used, but could last up to 60 minutes. Chloroprocaine is rapidly hydrolyzed in plasma by pseudocholinesterase. This hydrolysis…

NEULEPTIL® Rhône-Poulenc Rorer Pericyazine Psychotropic Agent Action And Clinical Pharmacology: Pericyazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects, and an action on the extrapyramidal system. Like other…

NERISALIC® Stiefel Diflucortolone Valerate – Salicylic Acid Topical Corticosteroid – Keratolytic Action And Clinical Pharmacology: Nerisalic combines the anti-inflammatory, antipruritic and vasoconstrictive activity of diflucortolone valerate and the keratolytic effects of salicylic acid. Both diflucortolone valerate and its split ester are topically active. Indications And Clinical Uses: The topical treatment of chronic eczema, psoriasis vulgaris, neuro-dermatitis and scaly crusty dermatoses which respond to corticosteroid therapy. Nerisalic is not suitable for…

NEOSPORIN® Preparations Glaxo Wellcome Polymyxin B – Neomycin Compound Antibiotic Indications And Clinical Uses: Cream: Infection in dermatologic disorders particularly where the lesions are moist or weeping. Prophylactically, against bacterial contamination in burns, skin grafts, incisions and other clean lesions. For abrasions, minor cuts and wounds, the cream may prevent infection and permit normal healing. Irrigating Solution: To be diluted and used as a continuous irrigant or rinse for short-term…

NegGram® Sanofi Nalidixic Acid Urinary Antibacterial Action And Clinical Pharmacology: Nalidixic acid has bactericidal activity against gram-negative rods such as Escherichia, Klebsiella, Aerobacter and Proteus. It is relatively inactive against gram-positive bacteria. The mode of action is believed to be interference with the replication of genetic information by the blocking of the synthesis of bacterial DNA. Bacterial cross-resistance between nalidixic acid and other quinolone antimicrobials has been observed only with…

NEO-MEDROL® Acne Lotion Pharmacia & Upjohn Methylprednisolone – Neomycin Compound Acne Therapy Indications And Clinical Uses: For control of acne vulgaris in the adolescent and young adult. Also in some cases of acne rosacea and seborrheic dermatitis. Contra-Indications: In tuberculosis of the skin, herpes simplex, vaccinia, varicella and in other cutaneous infections which do not respond to neomycin. Known hypersensitivity to any of the components. Precautions: Avoid contact with eyes….

NEO-CORTEF® Preparations Pharmacia & Upjohn Neomycin Sulfate – Hydrocortisone Acetate Antibiotic – Corticosteroid Indications And Clinical Uses: These preparations are indicated in the following conditions when threatened with or complicated by infection due to neomycin sensitive organisms. Eye Drops: phlyctenular kerato-conjunctivitis, nonspecific superficial keratitis, acne rosacea keratitis, allergic conjunctivitis, sclerokeratitis, episcleritis, traumatic keratitis. In generalized uveitis and inflammatory diseases of the posterior segment, systemic corticosteroid therapy should be employed. Ointment:…

NEORAL® SANDIMMUNE® I.V. Novartis Cyclosporine Immunosuppressant Caution: Transplantation: Only physicians experienced in immunosuppressive therapy and management of organ transplant patients should prescribe Neoral and Sandimmune I.V. Patients receiving the drug should be managed in centres staffed with professionals experienced in transplantation and the use of immunosuppressants and equipped with adequate laboratory facilities to monitor cyclosporine levels. The ability to measure cyclosporine blood levels facilitates the management of the patient. The…