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HUMULIN® Lilly Insulin, Human Biosynthetic Antidiabetic Agent Action And Clinical Pharmacology: Humulin is a polypeptide hormone consisting of a 21 amino acid A-chain and a 30 amino acid B-chain linked by two disulfide bonds. Humulin is found to be chemically, physically, biologically and immunologically equivalent to pancreatic human insulin which differs slightly from porcine or bovine insulin in amino acid composition. Studies indicate immunogenicity problems with biosynthetic human insulin (BHI)…

HONVOL® Carter Horner Diethylstilbestrol Diphosphate Prostatic Carcinoma Therapy Indications And Clinical Uses: For intensive and selective palliative therapy of inoperable prostatic carcinoma. Contra-Indications: Patients with active hepatic dysfunction or disease, especially of the obstructive type; a personal history of breast cancer, except in special circumstances; a history of cerebrovascular accident, coronary thrombosis or the presence of classical migraine; a history of thrombophlebitis or thromboembolic disease; partial or complete loss of…

HUMALOG™ Lilly Insulin Lispro Antidiabetic Agent Action And Clinical Pharmacology: Insulin lispro is a rapid-acting analogue of human insulin. Due to its quick onset of action, insulin lispro should be given within 15 minutes of a meal. Insulin lispro is created by inverting the natural Pro-Lys sequence in human insulin at positions 28 and 29 in the C terminal portion of the B-chain. This change in amino acid sequence slightly…

HUMATROPE® Lilly Somatropin Growth Stimulant Action And Clinical Pharmacology: Somatropin is a polypeptide hormone of recombinant DNA origin. The amino acid sequence is identical to that of human growth hormone of pituitary origin. Somatropin is synthesized in a strain of E. coli which has been modified by the addition of the gene for human growth hormone. Somatropin stimulates linear growth in pediatric patients lacking adequate normal endogenous growth hormone. Treatment…

HISTAMINE Bioniche Histamine Phosphate Diagnostic Aid Indications And Clinical Uses: To test the ability of the gastric mucosa to produce hydrochloric acid. Contra-Indications: The gastric histamine test is contraindicated in patients with a history of hypersensitivity to histamine products, in patients with hypotension, severe hypertension, vasomotor instability, bronchial asthma (past or present), urticaria (past or present), or severe cardiac, pulmonary or renal disease. Precautions: Attacks of severe asthma or other…

HISMANAL® Johnson & Johnson Merck Astemizole Histamine H1-Antagonist Action And Clinical Pharmacology: Astemizole is a potent, long-acting, and selective histamine H1-antagonist. It produces a dose-related inhibition of skin reactions to intradermal histamine. Astemizole inhibits the nose reaction to nasal challenge with histamine and allergens. It inhibits the bronchial reaction to inhaled histamine and allergens in asthmatic patients. Astemizole has extremely weak serotonin antagonism, no anticholinergic properties, antagonism of dopamine and…

HEXABRIX® 200 HEXABRIX® 320 Mallinckrodt Ioxaglate Meglumine – Ioxaglate Sodium Radiopaque Medium Action And Clinical Pharmacology: Following intravascular injection, Hexabrix is rapidly transported through the circulatory system to the kidneys and is excreted unchanged in the urine. The pharmacokinetics of intravascularly administered radiopaque contrast media are usually best described by a two compartment model with a rapid alpha phase for drug distribution and a slower beta phase for drug elimination….

HEXADROL® PHOSPHATE INJECTION Organon Teknika Dexamethasone Sodium Phosphate Corticosteroid Action And Clinical Pharmacology: After administration of the injection, dexamethasone sodium phosphate is rapidly converted into dexamethasone. This is a synthetic glucocorticoid which has 7 times the anti-inflammatory potency of prednisolone. Like other glucocorticoids, dexamethasone also has antiallergic, antitoxic, antishock, antipyretic and immunosuppressive properties. Dexamethasone has practically no water and salt-retaining properties and is, therefore, particularly suitable for use in patients…

HEXALEN® Lilly Altretamine Antineoplastic Agent Action And Clinical Pharmacology: Altretamine, better known in the scientific literature as hexamethylmelamine (HMM), is a synthetic cytotoxic antineoplastic s-triazine derivative. While altretamine bears structural similarity to, and cross-reactivity with, triethylenemelamine (TEM), a classical alkylating agent, evidence demonstrating altretamine to be an alkylating agent is not conclusive. Altretamine does not consistently demonstrate cross-resistance with classical alkylating agents used in rodent tumors or in human cancer…

HEALON® HEALON® GV Pharmacia & Upjohn Sodium Hyaluronate Ophthalmosurgical Aid Description: Sodium hyaluronate is a sterile, nonpyrogenic, viscoelastic preparation of a highly purified, noninflammatory, high molecular weight fraction of sodium hyaluronate. Healon contains 10 mg/mL of sodium hyaluronate 5 000 and Healon GV contains 14 mg/mL of sodium hyaluronate 7 000 dissolved in physiological sodium chloride-phosphate buffer (pH 7.0 to 7.5). This high molecular weight polymer is made up of…