You searched for : 'C'

IRON SALTS General Monograph Anemia Therapy Pharmacology: Iron is an important component of a number of enzymes necessary for energy transfer. It is also present in hemoglobin and myoglobin and is important in the metabolism of catecholamines and the functioning of neutrophils. Administration of iron preparations corrects erythropoietic abnormalities which are due to deficiency of iron. Iron does not stimulate erythropoiesis nor does it correct hemoglobin disturbances not caused by…

ISMO® Wyeth-Ayerst Isosorbide-5-Mononitrate Antianginal Action And Clinical Pharmacology: As with other organic nitrates, the principal pharmacological action of isosorbide-5-mononitrate, the major active metabolite of isosorbide dinitrate, is relaxation of vascular smooth muscle and consequent dilation of peripheral arteries and veins, especially the latter. Dilation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure…

INVIRASE™ Roche Saquinavir Mesylate HIV Protease Inhibitor – Antiretroviral Agent Action And Clinical Pharmacology: Saquinavir is a selective inhibitor of the viral pol-encoded aspartic protease which cleaves precursor molecules into the structural proteins of the mature virion core and activates reverse transcriptase during the HIV growth cycle. Because of these functions, this protease is essential for the release of infectious virus (as proved by active site mutagenesis). Saquinavir is a…

INTRALIPID® 10% INTRALIPID® 20% INTRALIPID® 30% Pharmacia & Upjohn Fat Emulsions I.V. Nutrition Action And Clinical Pharmacology: Intralipid acts as an energy source in patients for whom the usual i.v. therapy would not be adequate and as a source of essential fatty acids to prevent essential fatty acid deficiency. Providing sufficient amounts of calories to satisfy basal metabolic requirements plus the additional needs imposed by disease and/or surgical stress can…

INTRON A® Schering Interferon alfa-2b Biological Response Modifier Action And Clinical Pharmacology: Interferon alfa-2b has exhibited antiproliferative effects in preclinical studies employing both cell culture systems and human tumor xenografts in animals, and has demonstrated significant immunomodulatory activity in vitro. Interferon alfa-2b also inhibits viral replication in vitro and in vivo. Interferons exert their cellular activities by binding to specific membrane receptors on the cell surface. The results of several…

INFUFER® Sabex Iron Dextran Hematinic – Iron Supplement Action And Clinical Pharmacology: After i.m. injection, iron dextran is absorbed from the injection site into the capillaries and the lymphatic system. Circulating iron dextran is dissociated by the reticuloendothelial system. The ferric iron is transported by transferrin and incorporated into hemoglobin and storage sites. Only traces of unmetabolized iron dextran are excreted in urine, bile or feces. The drug is negligibly…

INNOHEP® Leo Tinzaparin Sodium Anticoagulant – Antithrombotic Action And Clinical Pharmacology: Tinzaparin is a low molecular weight (LMW) heparin, produced by enzymatic depolymerization of conventional heparin from porcine mucosa. It possesses antithrombotic activity mediated through antithrombin III. Pharmacokinetics: The pharmacokinetics of tinzaparin after a single s.c. injection have been studied in clinical trials by the measurement of plasma levels of anti-Xa activity, anti-IIa activity and APTT activity Results from clinical…

IMURAN® Glaxo Wellcome Azathioprine Immunosuppressive Agent Action And Clinical Pharmacology: Metabolism: Azathioprine is well absorbed following oral administration. Maximum serum radioactivity occurs at 1 to 2 hours after oral 5-azathioprine and decays with a half-life of 5 hours. This is not an estimate of the half-life of azathioprine itself but is the decay rate for all 5-containing metabolites of the drug. Because of extensive metabolism, only a fraction of the…

IMOGAM® RABIES PASTEURIZED Connaught Rabies Immune Globulin, Pasteurized (Human) Immunotherapeutic Agent – Passive Immunization Action And Clinical Pharmacology: Infection with rabies virus characteristically produces an acute illness with rapidly progressive CNS manifestations, including anxiety, dysphagia, and convulsions, and almost invariably progresses to death. Some patients may present with paralysis. Rabies virus is classified in the Rhabdovirus family. Rabies virus can infect any warm blooded animal. In North America, it occurs…

IMMUNINE® VH Baxter Factor IX Concentrate (Human) Blood Coagulation Factor Action And Clinical Pharmacology: Coagulation factor IX is one of the clotting factors found in normal human blood and is required for normal clot formation. I.V. administration of Immunine VH, factor IX concentrate (human) vapor heated, Immuno provides an increase in plasma levels of factor IX and can temporarily correct the coagulation defect of patients with factor IX deficiency. The…