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R & C™ Shampoo/Conditioner R & C Pyrethrins – Piperonyl Butoxide Pediculicide – Ovicide Indications And Clinical Uses: For the treatment of infestations with head lice (P. capitis), body lice (P. corporis), crab lice (P. pubis) and their nits. Contra-Indications: Should not be used by persons allergic to chrysanthemum, pyrethrin or synthetic pyrethroids. Precautions: For external use only. Harmful if swallowed. It should not be inhaled. During shampooing, contact should…

RIOPAN® RIOPAN® PLUS Whitehall-Robins Magaldrate Magaldrate – Simethicone Antacid Antacid – Antiflatulent Indications And Clinical Uses: Symptomatic relief of heartburn, indigestion and upset stomach due to excess acid, and relief of gas with Riopan Plus. Precautions: Individuals with kidney disease should not take this product except with the advice and supervision of a physician. Do not take with tetracycline antibiotics. Antacids can interfere with the absorption of iron preparations. Do…

RISPERDAL® Oral Solution RISPERDAL® Tablets Janssen-Ortho Risperidone Tartrate Risperidone Antipsychotic Agent Action And Clinical Pharmacology: Risperidone, a benzisoxazole derivative, is a novel antipsychotic drug which binds with high affinity to the serotonin type 2 (5-HT2), dopamine D2, and a1-adrenergic receptors. Risperidone binds with a lower affinity to the a2-adrenergic and histamine H1 receptors. Risperidone does not bind to dopamine D1 or muscarinic cholinergic receptors. Receptor occupancy was also demonstrated in…

RIFAMPIN General Monograph, Antibiotic Pharmacology: Rifampin is a semisynthetic derivative of rifamycin B, an antibiotic produced by Streptomyces mediterranei. Rifampin is active against microorganisms of the genus Mycobacterium, including M. tuberculosis, M. kansasii, M. marinum, M. avium-intracellulare (M. avium complex) and M. leprae. Rifampin is also active against some gram-negative bacteria including N. meningitidis and H. influenzae type b, in addition to some gram-positive bacteria including S. aureus and S. epidermidis….

RIFATER™ Hoechst Marion Roussel Rifampin – Isoniazid – Pyrazinamide Antituberculous Antibiotic Action And Clinical Pharmacology: Rifater is an antibacterial fixed combination product containing 120 mg rifampin, 50 mg isoniazid and 300 mg pyrazinamide used for the treatment of tuberculosis. Rifampin, isoniazid and pyrazinamide are bactericidal agents active against both intracellular and extracellular tuberculosis organisms. Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase,…

RIMSO®-50 Roberts Dimethyl Sulfoxide Genitourinary Disorders Action And Clinical Pharmacology: Dimethyl sulfoxide has a wide spectrum of primary pharmacologic activity including: membrane penetrant, solute carrier across membranes, anti-inflammatory, analgesia, diuresis, cholinesterase inhibition, muscle relaxation, vasodilation, penetrant of blood-brain barrier. Although the mode of action of dimethyl sulfoxide as a treatment for various inflammatory genitourinary disorders is speculative at this time, hypotheses centre around the following: anti-inflammation, analgesic, improvement of blood…

RIDAURA® Pharmascience Auranofin Antirheumatic Agent Action And Clinical Pharmacology: Auranofin is a gold preparation and therefore has the potential for serious gold toxicity. The mechanism by which auranofin exerts its therapeutic effect has not been established. In patients with adult rheumatoid arthritis or psoriatic arthritis, auranofin may modify disease activity as manifested by synovitis and associated symptoms, and reflected by laboratory parameters such as elevated ESR. There is no substantial…

RIFADIN® Hoechst Marion Roussel Rifampin Antituberculous Antibiotic Action And Clinical Pharmacology: Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase. This is the probable mechanism of action by which rifampin exerts its therapeutic effect. Pharmacokinetics: Absorption is more rapid when rifampin is administered 1 hour before meals. Peak blood levels in normal adults vary widely from individual to individual. Peak levels occur between…

RHINALAR® Roche Flunisolide Nasal Mist Allergic Rhinitis Therapy Action And Clinical Pharmacology: Flunisolide has demonstrated marked anti-inflammatory and antiallergic efficacy in classical animal test systems. It is a corticosteroid which is several hundred times more potent in animal anti-inflammatory assays than the cortisol standard. Clinical studies with flunisolide have shown a topical activity on the nasal mucous membrane with minimal associated systemic activity at the low spray doses administered. The…

RHEUMATREX™ Wyeth-Ayerst Methotrexate Sodium Antirheumatic Caution: Methotrexate should be used only by physicians whose knowledge and experience includes the use of antimetabolite therapy. Because of the possibility of serious toxic reactions the patient should be informed by the physician of the risks involved and should be under a physician’s constant supervision. Deaths have been reported with the use of methotrexate in the treatment of rheumatoid arthritis. In the treatment of…