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SABRIL® Hoechst Marion Roussel Vigabatrin Antiepileptic Action And Clinical Pharmacology: Vigabatrin is an irreversible inhibitor of gamma-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the catabolism of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain. The mechanism of action of vigabatrin is attributed to irreversible enzyme inhibition of GABA-T, and consequent increased levels of the inhibitory neurotransmitter, GABA. Decreased serum levels of ALT and AST have been observed during…

SAFE TUSSIN 30 LIQUID Indications And Clinical Uses: For temporary relief of cough due to minor throat and cough associated with the common cold or inhaled irritants. Helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus. DIRECTIONS Adults and children 12 years of age and over: 2 teaspoonfuls every 6 hours, not to exceed 8 teaspoonfuls in 24 hours. Children 6 to under…

SAIZEN DESCRIPTION Saizen® [somatropin (rDNA origin) for injection] is a human growth hormone produced by recombinant DNA technology. Saizen® has 191 amino acid residues and a molecular weight of 22,125 daltons. Its amino acid sequence and structure are identical to the dominant form of human pituitary growth hormone. Saizen® is produced by a mammalian cell line (mouse C127) that has been modified by the addition of the human growth hormone…

SYNFLEX® DS AltiMed Naproxen Sodium Analgesic-Anti-inflammatory Availability And Storage: Synflex: Each oval-shaped, blue, film-coated tablet, with SYNFLEX engraved on one side, contains: naproxen sodium 275 mg. Nonmedicinal ingredients: FD&C Blue #2 aluminum lake, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, talc and titanium dioxide. Bisulfite-, erythrosine-, gluten-, lactose-, sorbitol-, tartrazine- and xylitol-free. Bottles of 100 and 500. Synflex DS: Each oblong, dark blue, film-coated tablet, with SYNFLEX DS…

SYNTHROID® Knoll Levothyroxine Sodium Thyroid Hormone Action and Clinical The synthesis and secretion of the major thyroid hormones, L-thyroxine (T 4) and L-triiodothyronine (T 3), from the normally functioning thyroid gland are regulated by complex feedback mechanisms of the hypothalamic-pituitary-thyroid axis. The thyroid gland is stimulated to secrete thyroid hormones by the action of thyrotropin (thyroid stimulating hormone, TSH), which is produced in the anterior pituitary gland. TSH secretion is…

RUBRAMIN® Squibb Vitamin B12 Hematopoietic Action And Clinical Pharmacology: Vitamin B is essential for growth, cell reproduction, hematopoiesis, nucleoprotein and myelin synthesis. Within 48 hours after injection of 100 to 1 000 µg of vitamin B12, 50 to 98% of the injected dose may appear in the urine. The major portion is excreted within the first 8 hours. Indications And Clinical Uses: For vitamin B12 deficiency occurring in: pernicious anemia…

RYTHMODAN® RYTHMODAN®-LA Hoechst Marion Roussel Disopyramide Antiarrhythmic Agent Action And Clinical Pharmacology: In both animal and man the electrophysiological and hemodynamic effects of disopyramide are qualitatively similar to those of quinidine and procainamide. Although the exact mechanism of action has not been completely elucidated, it would appear from animal studies that disopyramide exerts its antiarrhythmic activity in the following manner: 1. Reduces automaticity in cardiac Purkinje fibers by depressing the…

ROGAINE® Pharmacia & Upjohn Minoxidil Hair Growth Stimulant Action And Clinical Pharmacology: When applied topically, minoxidil topical solution has been shown to stimulate hair growth in individuals with alopecia androgenetica (male pattern baldness). Although the exact mechanism of action of minoxidil in the treatment of alopecia androgenetica is not known, there may be more than one mechanism by which minoxidil stimulates hair growth; they include: vasodilation of the microcirculation around…

ROFERON®-A Roche Interferon alfa-2a Biological Response Modifier Action And Clinical Pharmacology: The mechanisms by which interferon alfa-2a, or any other interferon, exerts antitumor activity are not clearly understood. However, it is believed that the direct antiproliferative action against tumor cells and modulation of the host immune response play important roles in the antitumor activity. Interferon alfa-2a has been shown to exert antiproliferative activity against a variety of human tumors in…

Introduction Robitussin (guaifenesin) is an expectorant. It helps reduce congestion in your chest and throat, making it easier for you to cough out through your mouth. Here’s everything you need to know, including how it works, as well as uses, contraindications, side effects, interactions, storage and precautions. Action And Clinical Pharmacology Guaifenesin enhances the output of lower respiratory tract fluid. The enhanced flow of less viscid secretions promotes ciliary action, and…