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TAROSONE Taro Betamethasone Dipropionate Topical Corticosteroid Availability And Storage: Cream: Each g of cream contains: betamethasone 0.5 mg (as dipropionate USP) in a water miscible base of white petrolatum, mineral oil, cetostearyl alcohol, cetomacrogol 1 000, purified water, sodium phosphate monobasic, chlorocresol and propylene glycol with sodium hydroxide and phosphoric acid for pH correction. Tubes of 15 and 50 g. Jars of 450 g. Lotion: Each g of lotion contains:…

TASMAR™ Roche Tolcapone Antiparkinsonian – COMT-inhibitor Action And Clinical Pharmacology: Tolcapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). COMT catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure. Physiological substrates of COMT include dopa, catecholamines (dopamine, norepinephrine, epinephrine) and their hydroxylated metabolites. The function of COMT is the elimination of biologically active catechols and some other hydroxylated…

TARKA® Knoll Trandolapril – Verapamil HCl Antihypertensive Action And Clinical Pharmacology: Tarka is a formulation containing slow-release verapamil, a phenylalkylamine calcium channel blocker, along with immediate-release trandolapril, an angiotensin converting enzyme (ACE) inhibitor. Verapamil is a calcium channel blocker that exerts its pharmacologic effects by modulating the influx of ionic calcium across the cell membrane of the arterial smooth muscle as well as in conductile and contractile myocardial cells. Verapamil…

TARO-CARBAMAZEPINE Anticonvulsant-Symptomatic Relief of Trigeminal Neuralgia-Antimanic Action and Clinical Pharmacology Carbamazepine has anticonvulsant properties which have been found useful in the treatment of partial seizures (simple or complex) with and without secondary generalization, and generalized tonic-clonic seizures. A mild psychotropic effect has been observed in some patients, which seems related to the effect of carbamazepine in localization-related epilepsies and syndromes.: Clinical Trials: Evidence supporting the efficacy of carbamazepine as an…

TANACET 125® Ashbury Biologicals/Herbal Laboratories Standardized Feverfew Migraine Prophylaxis Action And Clinical Pharmacology: Clinical trials conducted in the United Kingdom have established the effectiveness of feverfew (Tanacetum parthenium) when taken daily over a 2-month period in reducing the frequency and intensity of migraine attacks. Tanacet 125 contains specially prepared and standardized feverfew leaf (Tanacetum parthenium) which is a recognized traditional herbal remedy for several conditions, including the prevention of migraine…

TAPAZOLE® Lilly Methimazole Antithyroid Action And Clinical Pharmacology: Methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. The drug does not inactivate existing thyroxine and triiodothyronine that are stored in colloid or are circulating in the blood, nor does it interfere with the effectiveness of thyroid hormones given by mouth or by injection. The actions and use of methimazole are similar to those…

TALWIN® Injection Sanofi Pentazocine Lactate Analgesic Action And Clinical Pharmacology: Analgesic effects: Pentazocine relieves pain of all degrees, from mild to severe, in patients with acute and chronic disorders, regardless of age or sex. Analgesia usually occurs within 15 to 30 minutes after i.m. or s.c. injection, or 2 to 3 minutes after i.v. injection, and lasts for 3 to 4 hours. A dose of 30 mg administered parenterally is…

TAMBOCOR™ 3M Pharmaceuticals Flecainide Acetate Antiarrhythmic Agent Action And Clinical Pharmacology: Flecainide belongs to the membrane stabilizing group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the 1C class of the modified Vaughan-Williams classification. It also possesses local anesthetic properties. In single cell preparations from canine cardiac tissue (Purkinje fibres) flecainide decreased the rate of rise (Vmax, Phase O) of the action potential without greatly affecting its duration; the…

T-STAT® Westwood-Squibb Erythromycin – Ethyl Alcohol Topical Anti-acne Therapy Action And Clinical Pharmacology: Ethyl alcohol is a drying and peeling agent. The mechanism of action of topically applied erythromycin in the treatment of acne vulgaris is not known. Indications And Clinical Uses: For the treatment of the inflammatory papular lesions of acne vulgaris. Not indicated for Grade IV acne. Contra-Indications: Individuals who have shown hypersensitivity to erythromycin or any of…

TAGAMET® SmithKline Beecham Cimetidine Histamine H2 Receptor Antagonist Action And Clinical Pharmacology: Cimetidine competitively inhibits the action of histamine at the histamine H2 receptor and thus represents a new class of pharmacological agents, the histamine H2 receptor antagonists. Cimetidine is not an anticholingeric agent. Studies have shown that cimetidine inhibits both daytime and nocturnal basal gastric acid secretion. Cimetidine also inhibits gastric acid secretion stimulated by food, histamine, pentagastrin, caffeine…