Tanacet 125 (Standardized Feverfew)


Ashbury Biologicals/Herbal Laboratories

Standardized Feverfew

Migraine Prophylaxis

Action And Clinical Pharmacology: Clinical trials conducted in the United Kingdom have established the effectiveness of feverfew (Tanacetum parthenium) when taken daily over a 2-month period in reducing the frequency and intensity of migraine attacks.

Tanacet 125 contains specially prepared and standardized feverfew leaf (Tanacetum parthenium) which is a recognized traditional herbal remedy for several conditions, including the prevention of migraine headache. As with most migraine preventative therapies, the exact method of action remains to be defined; however, clinical trials have demonstrated that the drug reduces the frequency and severity of migraine attacks. Additionally, the drug reduces the severity of migraine associated gastro-intestinal upset (nausea, vomiting).

Although the interrelated role of several biological principles may be important, a sesquiterpene lactone, parthenolide, has been accepted as a biological marker for antimigraine activity of the herbal product. Only a product that has a minimum of 0.2% parthenolide demonstrates a correlation with biological activity. This product is certified to contain 125 mg of feverfew leaf material per tablet with a minimum parthenolide assay equal to or exceeding the 0.2% parthenolide requirement. This differentiates Tanacet 125 from other feverfew products.

In vitro studies have demonstrated that parthenolide acts to inhibit the release of serotonin from platelets and white blood cells. The clinical significance of this observation is not presently understood.

Indications And Clinical Uses: Prophylaxis of migraine. Precautions

Precautions: Pregnancy and Lactation: Tanacet 125 should not be taken during pregnancy or when breast-feeding.

Patients should be instructed to consult a doctor to evaluate progress before continuing to use Tanacet 125 beyond 4 months. Discontinue use if sore mouth develops. Keep out of reach of children.

Adverse Reactions: Mild pruritus and occasional mouth sores have been reported in less than 7% of consumers; these reactions promptly cease with the reduction or discontinuation of Tanacet 125.

Dosage: Take 1 or 2 tablets daily with water after meals, preferably the first tablet after breakfast and the second after the evening meal. If mouth sores are experienced, discontinue use.

Availability And Storage: Each compressed tablet contains: specially selected standardized certified feverfew leaf powder 125 mg (provides a minimum of 0.2% parthenolide). Nonmedicinal ingredients: dicalcium phosphate, microcrystalline cellulose, silicon dioxide and vegetable magnesium stearate. Packages of 60.

TANACET 125® Ashbury Biologicals/Herbal Laboratories Standardized Feverfew Migraine Prophylaxis

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