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TYLENOL® McNeil Consumer Healthcare Acetaminophen Analgesic–Antipyretic Action and Clinical The analgesic and antipyretic effects of acetaminophen are believed to be related to the inhibition of prostaglandin synthetase (a mechanism shared by ASA and related drugs). It is postulated that the analgesic effect is produced by elevation of the pain threshold and the antipyretic effect is produced through action on the hypothalamic heat-regulating center. Acetaminophen is considered equipotent to ASA in…

TUBERCULIN PURIFIED PROTEIN DERIVATIVE (MANTOUX)–TUBERSOL® Connaught Tuberculin Test Action and Clinical Intracutaneous tuberculin testing is an accepted aid in the diagnosis of tuberculosis infection. The reaction to intracutaneously injected tuberculin is a delayed (cellular) hypersensitivity reaction. The reaction which characteristically shows a delayed course, reaching its peak more than 24 hours after administration, consists of induration due to cell infiltration and occasionally vesiculation and necrosis. Clinically, a delayed hypersensitivity reaction…

TUBERCULIN, OLD, TINE TEST® Wyeth-Ayerst Diagnostic Test Indications And Clinical Uses: For detection of tuberculin sensitive individuals, as a determinant for additional testing (i.e., chest x-rays), and in epidemiological surveys to identify those areas having high levels of infection. Also useful in mass tuberculosis screening programs. In clinical studies covering various geographical areas and all age groups, with a total of 30 588 test subjects, there were 911 (4%) false…

TUMS® Tablets SmithKline Beecham Consumer Healthcare Calcium Carbonate Calcium Supplement–Antacid Availability And Storage: Regular: Each tablet contains: calcium carbonate 500 mg equivalent to elemental calcium 200 mg. Security-sealed bottles of 75, 150, 180 and rolls of 12. Regular and assorted fruit flavors. Extra: Each tablet contains: calcium carbonate 750 mg equivalent to elemental calcium 300 mg. Security-sealed bottles of 50, 100, 120, 250 and rolls of 8. Regular, assorted mint,…

TROPICAMIDE Rivex Ophthalmics Mydriatic–Cycloplegic Availability And Storage: Each mL of sterile ophthalmic solution contains: tropicamide 1%. Nonmedicinal ingredients: benzalkonium chloride, boric acid, edetate disodium, hydrochloric acid, purified water and sodium hydroxide. Plastic squeeze bottles of 15 mL with controlled tip applicators. TROPICAMIDE Rivex Ophthalmics Mydriatic–Cycloplegic

TROSYD™ AF TROSYD™ J Pfizer Consumer Tioconazole Antifungal Agent Action and Clinical Tioconazole is a member of the imidazole class of antifungal agents. Although the mode of action of tioconazole has not as yet been determined, several studies have demonstrated that the imidazoles inhibit ergosterol synthesis in fungi by blocking C-14 demethylation. As a result, there is an accumulation of C-14 methyl sterol intermediates like langosterol, and a decrease in…

TRUSOPT® Merck Frosst Dorzolamide HCl Elevated Intraocular Pressure Therapy–Topical Carbonic Anhydrase Inhibitor Action and Clinical Dorzolamide is a carbonic anhydrase inhibitor formulated for topical ophthalmic use. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure (IOP). Unlike oral carbonic anhydrase…

TRYPTAN™ ICN L-Tryptophan Adjunct in the Management of Affective Disorders Action and Clinical The rationale for the use of L-tryptophan in affective disorders is based on clinical findings more than 20 years ago, that L-tryptophan increases 5-HT (serotonin) synthesis in the CNS of humans. It has been demonstrated in clinical trials that oral ingestion of L-tryptophan in humans caused a significant increase in the level of the serotonin metabolite, 5-hydroxyindoleacetic…

TRIPTIL® Merck Frosst Protriptyline HCl Antidepressant Indications And Clinical Uses: In the treatment of depression that is a manifestation of psychosis or neurosis, whether endogenous or reactive in nature. Endogenous depression is more likely to respond than other depressive states. It is especially recommended for apathetic, withdrawn patients because it promptly relieves anergia and lacks sedative activity. These qualities make it useful also in ambulatory depressed patients. When used in…

TRISORALEN™ ICN Trioxsalen Melanizing Agent Action And Clinical Pharmacology: Trioxsalen is a synthetic melanizing agent structurally and pharmacologically related to methoxsalen. The normal pigmentation of the skin is due to melanin, which is produced in the cytoplasm of the melanocytes located in the basal layers of the epidermis at its junction with the dermis. Melanin is formed by the oxidation of tyrosine to DOPA (dihydroxyphenylalanine) with tyrosinase as catalyst. This…