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MITOMYCIN FOR INJECTION USP Novopharm Antineoplastic Action And Clinical Pharmacology: Mitomycin was first investigated as an antibiotic in Japan. It was then found to be active as an antineoplastic agent. It selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The exact point of mitomycin attachment to DNA remains unknown. There is a correlation between the guanine and cytosine content of DNA and the degree of mitomycin-induced cross-linking. At high concentrations…

MIVACRON® Glaxo Wellcome Mivacurium Chloride Nondepolarizing Skeletal Neuromuscular Blocking Agent Action And Clinical Pharmacology: Mivacurium is a short-acting, nondepolarizing skeletal neuromuscular blocking agent which is hydrolyzed by plasma cholinesterase. Mivacurium results in a blockade of neuromuscular transmission by binding competitively with cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine. Pharmacodynamics: The time to maximum neuromuscular block is similar for mivacurium and intermediate-acting agents (e.g., atracurium), but…

MICRO-K EXTENCAPS® MICRO-K-10 EXTENCAPS® Wyeth-Ayerst Microencapsulated Potassium Chloride Potassium Supplement Action And Clinical Pharmacology: Potassium ions participate in a number of physiological processes including the maintenance of intracellular tonicity; the transmission of nerve impulses; the contraction of cardiac, skeletal and smooth muscle; and the maintenance of normal renal function. Depletion may occur whenever the rate of potassium loss through renal excretion and/or loss from the gastrointestinal tract exceeds the rate…

METHYLENE BLUE Bioniche Tetramethylthionine Chloride Trihydrate Methemoglobinemia – Diagnostic Aid Action And Clinical Pharmacology: Methylene Blue activates a normally dormant reductase enzyme system which reduces the methylene blue to leucomethylene blue, which in turn is able to reduce methemoglobin to hemoglobin. Methylene Blue is absorbed from the gastrointestinal tract. It is believed to be reduced in the tissues to the leuco form which is slowly excreted, mainly in the urine…

METHOTREXATE TABLETS USP Faulding Antimetabolite Action And Clinical Pharmacology: Methotrexate is an antimetabolite which competitively inhibits the enzyme folic acid reductase. During DNA synthesis and cellular reproduction, folic acid is reduced to tetrahydrofolic acid by the enzyme folic acid reductase. By interfering with the reduction of folic acid, methotrexate interferes with tissue cell reproduction. Generally, the most sensitive cells to the antimetabolite effect of methotrexate are those cells which are…

METHYLPREDNISOLONE SODIUM SUCCINATE FOR INJECTION USP Faulding Glucocorticoid – Anti-inflammatory Action And Clinical Pharmacology: Methylprednisolone is a synthetic adrenocortical steroid derivative with predominantly glucocorticoid properties possessing anti-inflammatory and immunosuppressive action. Methylprednisolone belongs to the pharmacologic class of glucocorticoid/anti-inflammatory drugs which, following systemic absorption, diffuse across cell membranes and complex with specific cytoplasmic receptors. These complexes may enter the cell nucleus, bind to DNA and stimulate transcription of mRNA. Subsequent cellular…

METIMYD® Schering Prednisolone – Sulfacetamide Compound Ophthalmic Corticosteroid – Antibacterial Indications And Clinical Uses: Inflammatory and allergic disease of the eye especially when antibacterial effect is desired. Contra-Indications: Tuberculosis, fungal and most viral lesions of the eye (herpes simplex/dendritic keratitis): vaccinia; varicella; acute purulent conjunctivitis and acute purulent blepharitis and in those persons who have shown hypersensitivity to any of its components. Precautions: Extended use of topical steroid therapy may…

METHOTREXATE SODIUM INJECTION USP Faulding Antimetabolite Action And Clinical Pharmacology: Methotrexate is an antimetabolite which competitively inhibits the enzyme folic acid reductase. During DNA synthesis and cellular reproduction, folic acid is reduced to tetrahydrofolic acid by the enzyme folic acid reductase. By interfering with the reduction of folic acid, methotrexate interferes with tissue cell reproduction. Generally, the most sensitive cells to the antimetabolite effect of methotrexate are those cells which…

METAMUCIL® Preparations Procter & Gamble Psyllium Hydrophilic Mucilloid Laxative – Fibre Supplement Indications And Clinical Uses: The relief of chronic, atonic, spastic and rectal constipation and for the constipation accompanying pregnancy, convalescence and advanced age. As adjunctive therapy in the constipation of mucous and ulcerative colitis and diverticulitis. To provide supplementary dietary fibre in special dietary programs. Also useful in the management of hemorrhoids and following anorectal surgery. Contra-Indications: Presence…

MERCODOL® with DECAPRYN® Hoechst Marion Roussel Hydrocodone Bitartrate – Etafedrine HCl Sodium Citrate – Doxylamine Succinate Antihistaminic – Antitussive – Decongestant Indications And Clinical Uses: The treatment of cough associated with inflamed mucosa, which does not respond to products of lesser potency. Contra-Indications: Patients receiving MAO inhibitors, sensitivity to any of the components. Precautions: Before prescribing medication to suppress or modify cough, it is important to ascertain that the underlying cause…