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PRESUN® ULTRA 30 Preparations Westwood-Squibb Octyl Methoxycinnamate – Octyl Salicylate – Oxybenzone – Butyl Methoxydibenzoyl – Methane (Parsol® 1789) Sunscreen Indications And Clinical Uses: A waterproof, non-PABA sunscreen for extremely sun-sensitive patients, or those patients who exhibit a sensitivity to PABA or its esters. Offers maximum UVA and UVB sun protection. Regular usage may help prevent premature aging and wrinkling of the skin due to sun overexposure. Precautions: For external…

PRESUN® SUNBLOCK 28 Westwood-Squibb Titanium Dioxide Sunscreen Indications And Clinical Uses: A waterproof, titanium dioxide sunscreen which physically blocks UVA and UVB rays and does not contain PABA or other chemical-sensitizing sunscreens. This broad spectrum, fragrance-free product is ideally suited for sensitive skin. This product is appropriate for daily sunscreen use for the whole family. Precautions: For external use only. If irritation or rash develops, discontinue use. Use on children…

PREMARIN® TABLETS Wyeth-Ayerst Conjugated Estrogens Estrogenic Hormones Action And Clinical Pharmacology: Estrogen drug products act by regulating the transcription of a limited number of genes. They may act directly at the cell’s surface via non “estrogen receptor” mechanism or directly with the estrogen receptor inside the cell. Estrogens diffuse through cell membranes, distribute themselves throughout the cell, and bind to and activate the nuclear estrogen receptor, a DNA-binding protein which…

PRENAVITE® Roberts Iron – Calcium – Vitamins Prenatal Supplement With Folic Acid Indications And Clinical Uses: As a dietary supplement to meet increased needs in pregnancy and lactation. Contra-Indications: Hemosiderosis, hemochromatosis, hemolytic anemias. Precautions: Neurologic involvement may develop or progress, despite temporary remission of anemia, in patients with pernicious anemia who receive more than 100 g of folic acid per day and who are inadequately treated with vitamin B12. Periodic…

PREPULSID® Janssen-Ortho Cisapride Monohydrate Gastrointestinal Prokinetic Agent Action And Clinical Pharmacology: Cisapride is a gastrokinetic drug whose activity is considered to be due to enhancement of the physiological release of acetylcholine at the myenteric plexus. Cisapride increases esophageal peristaltic activity and lower esophageal sphincter tone, thereby decreasing reflux of gastric contents into the esophagus and improving esophageal clearance. Gastric and duodenal emptying are also enhanced by cisapride as a consequence…

PRAVACHOL® Squibb Pravastatin Sodium Lipid Metabolism Regulator Action And Clinical Pharmacology: Pravastatin is one of a new class of lipid-lowering compounds known as HMG-CoA reductase inhibitors (statins) that reduce cholesterol biosynthesis. These agents are competitive inhibitors of 3-hydroxy- 3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme catalyzing the early rate-limiting step in cholesterol biosynthesis, conversion of HMG-CoA to mevalonate. Pravastatin is isolated from a strain of Penicillium citrinum. The active drug substance…

PREMARIN® VAGINAL CREAM Wyeth-Ayerst Conjugated Estrogens Vaginitis Therapy Action And Clinical Pharmacology: Conjugated estrogens are a mixture of estrogens obtained exclusively from natural sources occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. It contains estrone, equilin, and 17a-dihydroequilin, together with smaller amounts of 17a-estradiol, equilenin, and 17a-dihydroequilenin as salts of their sulfate esters. Metabolic and Somatic…

POTASSIUM SALTS General Monograph, Potassium Replacement Therapy Action And Clinical Pharmacology: Potassium is the principal intracellular ion of body tissues. Potassium ions are involved in a number of essential physiological processes, such as the maintenance of intracellular acid-base balance and tonicity. Other functions include the transmission of nerve impulses, contraction of cardiac, skeletal and smooth muscle, gastric secretion, normal renal function, tissue synthesis and carbohydrate metabolism. Hypokalemia: Potassium depletion may…

POTASSIUM CHLORIDE FOR INJECTION CONCENTRATE USP Astra Electrolyte Replenisher Indications And Clinical Uses: The treatment of potassium depletion in patients with hypokalemia; treatment of digitalis intoxication. The i.v. route is indicated when the patient is unable to take potassium orally or if hypokalemia is severe. Contra-Indications: Renal impairment with oliguria or azotemia, untreated Addison’s disease, hyperadrenalism associated with adrenogenital syndrome, extensive tissue breakdown as in severe burns, acute dehydration, heat…

POSTACNE® Dermik Laboratories Canada Sulfur Acne Therapy Indications And Clinical Uses: For use in early mild adolescent acne or excessively oily skin and as maintenance therapy for acne that has been controlled. Precautions: Keep away from eyes. Discontinue use temporarily if excessive irritation or scaling occurs. For external use only. Dosage: Shake lotion well. Apply a thin film over area, allow to dry, blend in with skin by gently brushing…