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CORDARONE® CORDARONE® I.V. Wyeth-Ayerst Amiodarone HCl Antiarrhythmic Agent Action And Clinical Pharmacology: Amiodarone is generally considered a class III antiarrhythmic drug, but it possesses electrophysiologic characteristics of all 4 Vaughan Williams classes. Like Class I drugs, amiodarone blocks sodium channels at rapid pacing frequencies, and like class II drugs, it exerts antisympathetic activity. One of its main effects, with prolonged administration, is to lengthen the cardiac action potential, a class…

COMPLEAT™ MODIFIED Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A blenderized tube feeding formulated from traditional foods including meat, vegetables and fruit for patients with normal gastrointestinal function. Recommended for both short-term and long-term tube feeding. Not recommended when a low residue tube feeding is required. Precautions: Not for parenteral administration. Dosage And Administration: 6 cans [1 500 mL or 6 700 kJ (1 600 kcal)] provides at least…

COMPLEX 15® Schering Dimethicone – Lecithin Emollient Indications And Clinical Uses: To soothe and relieve dry, sensitive skin. Phospholipid lecithin is a water-binding agent which occurs naturally in the deepest layers of the skin. Each phospholipid molecule forms a complex of 15 water molecules creating a moisture reservoir which restores the skin’s moisture balance. Dosage: Apply as often as needed to the hands, body and face. Availability And Storage: Face…

CONDYLINE™ Canderm Pharma Podofilox Antimitotic Agent Action And Clinical Pharmacology: Necrosis of visible tissue is observed following treatment of genital warts with podofilox. The exact mechanism of action is unknown. Podofilox is believed to exert its antimitotic effect by binding to tubulin, at a site close to but not identical to the binding site of colchicine; it is thought that this antimitotic effect causes necrosis of wart tissue, the observed…

COLYTE™ R & C PEG-3350 – Electrolytes Colon Electrolyte Lavage Preparation Action And Clinical Pharmacology: Colyte cleanses the bowel by induction of diarrhea. The osmotic activity of polyethylene glycol 3350, in combination with the electrolyte concentration, results in virtually no net absorption or secretion of ions or water. Accordingly, large volumes may be administered without significant changes in fluid and electrolyte balance. Indications And Clinical Uses: For bowel cleansing prior…

COMBANTRIN® Pfizer Consumer Pyrantel Pamoate Anthelmintic Action And Clinical Pharmacology: Pyrantel exerts its anthelmintic effect by interfering with the neuromuscular function of the parasite. It is also a cholinesterase inhibitor and a ganglionic stimulant. The anthelmintic activity of pyrantel has been demonstrated in several animal models. These tests carried out in mice and dogs showed the compound to be effective against intestinal nematodes representative of those found in humans, such…

Colchicine (Oral) General Monograph, Gout Therapy Action And Clinical Pharmacology: Although its exact mode of action in the relief of gout is not completely understood, colchicine is known to decrease the inflammatory response to urate crystal deposition by inhibiting migration of leukocytes, to interfere with urate deposition by decreasing lactic acid production by leukocytes, to interfere with kinin formation and to diminish phagocytosis and the subsequent anti-inflammatory response. The anti-inflammatory…

COLESTID® Pharmacia & Upjohn Colestipol HCl Oral Antihypercholesterolemic Action And Clinical Pharmacology: Colestipol is hygroscopic, water insoluble, and it is neither hydrolyzed by digestive enzymes nor is it absorbed. Colestipol binds with bile acids in the intestine forming a complex that is excreted in the feces. This non-systemic action results in a continuous, partial removal of bile acids from the enterohepatic circulation preventing their reabsorption. This increased fecal loss of…

COLPERMIN™ R & C Peppermint Oil Symptomatic Relief of Irritable Bowel Syndrome Action And Clinical Pharmacology: The mechanism of action of peppermint oil or its major component, menthol, in reducing lower bowel motility has not been completely elucidated. It has been postulated that peppermint oil exerts its gastrointestinal smooth muscle inhibitory effect by altering calcium ion transport. Using intraluminal pressure recordings and ultrasound measurements of colonic activity it has been…

COATED ASPIRIN® Bayer Consumer ASA Analgesic – Anti-inflammatory – Antipyretic Indications And Clinical Uses: 80 mg: For use in children only for rheumatic and arthritic pain under the supervision of a physician. Do not use to treat fever. 325 mg/500 mg/650 mg: For the temporary relief of arthritic and rheumatic pain, muscle aches, joint pain and back pain. Coated Aspirin has a special enteric coating recommended by doctors to help…