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MD-76® Mallinckrodt Diatrizoate Meglumine – Diatrizoate Sodium Radiopaque Medium Action And Clinical Pharmacology: Following intravascular injection, MD-76 is rapidly transported through the bloodstream to the kidneys and is excreted unchanged in the urine by glomerular filtration. When urinary tract obstruction is severe enough to block glomerular filtration, the agent appears to be excreted by the tubular epithelium. Renal accumulation is sufficiently rapid that the period of maximal opacification of the…

MEDROL® Acne Lotion Pharmacia & Upjohn Methylprednisolone – Aluminum Chlorhydroxide – Sulfur Acne Therapy Action And Clinical Pharmacology: Medrol Acne Lotion has an anti-inflammatory action by virtue of its content of methylprednisolone, as astringent and antiperspirant action by virtue of its content of aluminum chlorhydroxide and a keratolytic effect by virtue of its sulfur content. Sulfur has also demonstrated some antibacterial activity at the concentration used. Indications And Clinical Uses:…

MEDROL® Pharmacia & Upjohn Methylprednisolone Glucocorticoid Indications And Clinical Uses: Endocrine Disorders: Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance). Congenital adrenal hyperplasia. Nonsuppurative thyroiditis. Hypercalcemia associated with cancer. Nonendocrine Disorders: Rheumatic Disorders: As adjunctive therapy for short-term administration (to tide the patient over an acute episode…

MAVIK™ Knoll Trandolapril Angiotensin Converting Enzyme Inhibitor Action And Clinical Pharmacology: Trandolapril is a nonsulfydryl angiotensin converting enzyme (ACE) inhibitor, which is used in the treatment of mild to moderate essential hypertension and following acute myocardial infarction in stabilized patients with left ventricular dysfunction. Angiotensin converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the pharmacologically active substance, angiotensin II, which is a vasopressor…

MAXERAN® Hoechst Marion Roussel Metoclopramide HCl Modifier of Upper Gastrointestinal Tract Motility – Antiemetic Action And Clinical Pharmacology: Metoclopramide is a benzamide derivative, structurally related to procainamide and sulpiride. As with sulpiride, it has dopamine-antagonist activity with selective affinity for D-2 (non-adenylate cyclase-linked) receptors. The behavioral, motor, and neuroendocrine effects of metoclopramide have been linked to its antidopaminergic activity. Metoclopramide has antiemetic properties, which are believed to result from its…

MAXIPIME™ Bristol-Myers Squibb Cefepime HCl Antibiotic Action And Clinical Pharmacology: Cefepime is a semi-synthetic broad spectrum cephalosporin antibiotic intended for i.m. or i.v. administration. Cefepime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. It has a broad spectrum of activity against a wide range of gram-positive and gram-negative bacteria. The average elimination half-life of cefepime is approximately 2 hours, and does not vary with respect…

MANERIX® Roche Moclobemide Antidepressant Action And Clinical Pharmacology: Moclobemide is a short-acting, reversible inhibitor of monoamine oxidase (MAO). It is a benzamide derivative which inhibits the deamination of serotonin, norepinephrine and dopamine. This action leads to increased concentrations of these neurotransmitters, which may account for the antidepressant activity of moclobemide. MAOs are currently subclassified into 2 types, A and B, which differ in their substrate specificity. Moclobemide preferentially inhibits MAO-A;…

MARVELON® Organon Desogestrel – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: Combination oral contraceptives act by suppression of gonadotropins. Although the primary mechanism of this action is inhibition of ovulation, other alterations include changes in the cervical mucus (which increase the difficulty of sperm entry into the uterus) and the endometrium (which reduce the likelihood of implantation). Desogestrel, the progestogen component of Marvelon, displays low androgenic activity in relation…

MARINOL® Sanofi Dronabinol Antiemetic Action And Clinical Pharmacology: Dronabinol, also known as delta-9-tetrahydrocannabinol has been shown to have psychotropic and antiemetic activity. Dronabinol can produce changes in mood, decrease in cognitive performance and memory, decrease in ability to control drives and impulses, and altered perception of reality, particularly altered time sense. Pharmacokinetics: Dronabinol is readily absorbed from the gastrointestinal tract. The systemic availability, following oral administration, is 10 to 20%…

MANDOL® Lilly Cefamandole Nafate Antibiotic Action And Clinical Pharmacology: Cefamandole, a semisynthetic cephalosporin antibiotic, possesses properties similar to other members of this group, but has a broader spectrum of activity particularly with respect to the treatment of Gram-negative bacillary infections. Cefamandole has been shown to be active against the following organisms in vitro: Gram-positive: b-hemolytic and other strains of streptococci including S. pneumoniae (many strains of S. faecalis are resistant),…