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ROGAINE® Pharmacia & Upjohn Minoxidil Hair Growth Stimulant Action And Clinical Pharmacology: When applied topically, minoxidil topical solution has been shown to stimulate hair growth in individuals with alopecia androgenetica (male pattern baldness). Although the exact mechanism of action of minoxidil in the treatment of alopecia androgenetica is not known, there may be more than one mechanism by which minoxidil stimulates hair growth; they include: vasodilation of the microcirculation around…

ROFERON®-A Roche Interferon alfa-2a Biological Response Modifier Action And Clinical Pharmacology: The mechanisms by which interferon alfa-2a, or any other interferon, exerts antitumor activity are not clearly understood. However, it is believed that the direct antiproliferative action against tumor cells and modulation of the host immune response play important roles in the antitumor activity. Interferon alfa-2a has been shown to exert antiproliferative activity against a variety of human tumors in…

ROGITINE® Novartis Pharmaceuticals Phentolamine Mesylate Alpha-adrenoreceptor Blocker Action And Clinical Pharmacology: Phentolamine produces an alpha-adrenergic block of relatively short duration. It also has direct but less marked positive inotropic and chronotropic effects on cardiac muscle and vasodilator effects on vascular smooth muscle. tag_IndicationsIndications Indications And Clinical Uses: Prevention and control of hypertensive episodes in patients with pheochromocytoma, preoperatively and during surgical excision. Prevention of dermal necrosis and sloughing following i.v….

ROVAMYCINE® Rhône-Poulenc Rorer Spiramycin Antibiotic Action And Clinical Pharmacology: It is active against the following gram-positive organisms: S. aureus (including penicillin resistant strains), beta-hemolytic streptococci, S. viridans, S. faecalis and S. pneumoniae, C. diphtheriae, clostridia. Except for B. pertussis, H. influenzae (approximately 50% of strains) and neisseria, gram-negative organisms are generally considered as resistant to spiramycin. Bacterial resistance to spiramycin has been reported to develop, including cross resistance between spiramycin…

ROBINUL® ROBINUL® FORTE Wyeth-Ayerst Glycopyrrolate Anticholinergic Indications And Clinical Uses: The management of gastrointestinal disorders amenable to anticholinergic therapy, such as: duodenal ulcer, duodenitis, pylorospasm; gastric ulcer, gastritis, hiatal hernia, hyperchlorhydria, pyrosis, aerophagia, gastroenteritis; esophagitis; cholecystitis, chronic pancreatitis; spastic and irritable colon, ulcerative colitis, functional bowel distress, diverticulitis, acute enteritis, diarrhea; and splenic flexure syndrome, neurogenic gastrointestinal disturbances. Contra-Indications: Glaucoma, urinary bladder neck obstruction, pyloric obstruction, stenosis with significant gastric…

Introduction Robitussin (guaifenesin) is an expectorant. It helps reduce congestion in your chest and throat, making it easier for you to cough out through your mouth. Here’s everything you need to know, including how it works, as well as uses, contraindications, side effects, interactions, storage and precautions. Action And Clinical Pharmacology Guaifenesin enhances the output of lower respiratory tract fluid. The enhanced flow of less viscid secretions promotes ciliary action, and…

ROCEPHIN® Roche Ceftriaxone Sodium Antibiotic Action And Clinical Pharmacology: In vitro studies indicate that the bactericidal action of ceftriaxone results from the inhibition of cell-wall synthesis. In E. coli, ceftriaxone showed a high affinity for penicillin binding proteins (PBP) 1a and 3 and a moderate affinity for 1b and 2. In H. influenzae, the highest affinity was shown for PBP 4 and PBP 5. The binding affinity to PBP 4…

ROCALTROL® Roche Calcitriol Vitamin D3 Metabolite Action And Clinical Pharmacology: The supply of vitamin D in man depends on dietary intake and/or exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol to vitamin D3 (cholecalciferol). Vitamin D3 (cholecalciferol) must be metabolized in the liver and the kidneys before it is fully active on its target tissues. The initial transformation is catalyzed by a vitamin D3-25-hydroxylase enzyme (25-OH-ase)…

ROBAXIN® ROBAXIN®-750 Whitehall-Robins Methocarbamol Skeletal Muscle Relaxant Action And Clinical Pharmacology: The mechanism of action of methocarbamol has not been established, but may be due to general CNS depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber. Methocarbamol is metabolized to yield a dealkylated and a hydroxylated product. These 2 metabolites are found primarily as glucuronide and sulfate…

Introduction Robaxacet is an adult medication used to treat muscle spasms and pain. It helps to relax the muscles and decrease the pain. Its effects can be felt within 1 hour. Action And Clinical Pharmacology This product provides a dual approach to the management of discomforts associated with musculoskeletal disorders. The mechanism of action of methocarbamol has not been established, but may be due to general CNS depression. It has no…