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TOFRANIL® Novartis Pharmaceuticals Imipramine HCl Antidepressant Action and Clinical Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. It possesses anticholinergic properties which are responsible for certain of its side effects. The mechanism of action of imipramine and other tricyclic antidepressants is not well established, but it is thought that it might be related to their…

TOBI™ PathoGenesis Tobramycin (as sulfate) Respiratory Antibiotic Action and Clinical Uses: Pharmacology TOBI is a formulation of tobramycin designed specifically for administration by inhalation. When tobramycin solution for inhalation is inhaled, tobramycin can be detected at high concentration in the sputum of cystic fibrosis patients.: The drug substance, tobramycin, is an aminoglycoside antibiotic derived from S. tenebrarius. Tobramycin, a cationic polar molecule that does not readily cross epithelial membranes, is…

TISSEEL® KIT VH Baxter Fibrin Sealant Description: Tisseel’s action simulates key features of the physiological process of wound closure. A highly concentrated fibrinogen aprotinin solution, which among other ingredients contains Factor XIII, and a solution of thrombin and calcium chloride are applied to the wound area, where the mixture coagulates. The presence of Factor XIII causes the fibrin to crosslink, which gives the coagulum additional resilience. Tisseel-sealant is a tissue glue…

TOBRADEX® Alcon Tobramycin-Dexamethasone Antibiotic-Corticosteroid Action and Clinical Uses: Dexamethasone, a potent corticosteroid, suppresses the inflammatory response to chemical, immunological or mechanical irritants. The bactericidal activity of tobramycin is accomplished by specific inhibition of normal protein synthesis in susceptible bacteria. Indications And Clinical Uses: For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial ocular infection exist. Ocular steroids are indicated…

TOBRAMYCIN SULFATE INJECTION, USP, STERILE Schein Pharmaceutical Antibiotic Availability And Storage: 10 mg/mL: Each mL of solution contains: tobramycin sulfate equivalent to tobramycin 10 mg. Nonmedicinal ingredients: edetate disodium, phenol, sodium metabisulfite and water for injection. May contain sodium hydroxide and/or sulfuric acid for pH adjustment. Rubber stoppered vials of 2 mL for single use, cartons of 25. 40 mg/mL: Each mL of solution contains: tobramycin sulfate equivalent to tobramycin…

TIMOPTIC®, TIMOPTIC-XE® Merck Frosst Timolol Maleate Elevated Intraocular Pressure Therapy Action and Clinical Timolol is a general beta-adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant or local anesthetic (membrane-stabilizing) activity. Timolol combines reversibly with a part of the cell membrane, the beta-adrenergic receptor, and thus inhibits the usual biologic response that would occur with stimulation of that receptor. This specific competitive antagonism blocks stimulation…

TIMPILO® Merck Frosst Timolol Maleate-Pilocarpine HCl Elevated Intraocular Pressure Therapy Action and Clinical Uses: Timolol is a nonselective beta-adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Timolol combines reversibly with a part of the cell membrane, the beta-adrenergic receptor, and thus inhibits the usual biologic response that would occur with stimulation of that receptor. This specific competitive antagonism blocks stimulation…

TINACTIN® JOCK ITCH, TINACTIN® PLUS Schering Tolnaftate Topical Antifungal Indications And Clinical Uses: Topical treatment for tinea pedis, tinea cruris, tinea corporis, and tinea manuum due to infection with T. rubrum, T. mentagrophytes, T. tonsurans, M. audouini, E. floccosum, and for tinea versicolor due to M. furfur. Good results can be anticipated in patients with recent, mild fungus infection of the scalp (tinea capitis) treated with Tinactin solution. An oral…

TIM-AK Dioptic Timolol Maleate Elevated Intraocular Pressure Therapy Availability And Storage: Each mL of sterile ophthalmic solution contains: timolol maleate equivalent to timolol 0.5%. Nonmedicinal ingredients: benzalkonium chloride, dibasic sodium phosphate, monobasic sodium phosphate, purified water, sodium chloride and sodium hydroxide. Plastic dropper bottles of 5 and 10 mL. Store between 15 and 30°C. Protect from light and freezing. TIM-AK Dioptic Timolol Maleate Elevated Intraocular Pressure Therapy

TIMENTIN® SmithKline Beecham Ticarcillin Disodium-Potassium Clavulanate Antibiotic-b-Lactamase Inhibitor Action and Clinical Ticarcillin exerts a bactericidal action against sensitive organisms during the stage of active multiplication through the inhibition of the biosynthesis of bacterial cell wall mucopeptides. Clavulanic acid inhibits specific b-lactamases of some microorganisms and allows ticarcillin to inhibit ticarcillin resistant organisms which produce clavulanic acid sensitive b-lactamases.IndicationsIndications: Indications And Clinical Uses: For the treatment of the following infections when…