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TIMOLIDE® Merck Frosst Timolol Maleate-Hydrochlorothiazide Antihypertensive Action and Clinical Uses: Timolide combines the antihypertensive activity of 2 agents: a beta-adrenergic receptor blocking agent (timolol maleate) and a diuretic (hydrochlorothiazide). Timolol is a non-selective beta-adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane stabilizing) activity in humans. The mechanism of the antihypertensive effect of beta-adrenergic receptor blocking agents has not yet been…

TIAMOL® Spectropharm Dermatology Fluocinonide Topical Corticosteroid Action and Clinical Uses: Fluocinonide is effective because of the anti-inflammatory, antipruritic and vasoconstrictor actions of fluocinonide.IndicationsIndications: Indications And Clinical Uses: For topical use in the management of acute or chronic dermatoses responsive to corticosteroids. Contra-Indications: Topical corticosteroids are contraindicated in tuberculosis, fungal, most viral lesions of the skin (including herpes simplex, vaccinia and varicella), untreated bacterial infections and also contraindicated in individuals with…

TIAZAC® Crystaal Diltiazem HCI Antihypertensive-Antianginal Action and Clinical Uses: Diltiazem is a calcium ion cellular influx inhibitor (calcium entry blocker or calcium ion antagonist).: Mechanism of Action: The therapeutic effect of this group of drugs is believed to be related to their specific cellular action of selectively inhibiting transmembrane influx of calcium ions into cardiac muscle and vascular smooth muscle. The contractile processes of these tissues are dependent upon the…

TICLID® Roche Ticlopidine HCl Inhibitor of Platelet Function Action and Clinical Uses: Ticlopidine is an inhibitor of platelet aggregation. It causes a time and dose-dependent inhibition of platelet aggregation and release of platelet factors, as well as a prolongation of bleeding time. The drug has no significant in vitro activity. The exact mechanism of action is not fully characterized, but does not involve inhibition of the prostacyclin/thromboxane pathways or platelet…

TILADE® Rh´ne-Poulenc Rorer Nedocromil Sodium Bronchial Anti-inflammatory Agent Action and Clinical Uses: Nedocromil sodium is a new chemical entity that inhibits the release of inflammatory mediators from a variety of cell types occurring in the lumen and in the mucosa of the bronchial tree. When it is administered topically to the bronchi, it displays specific anti-inflammatory properties. Laboratory experiments have shown that nedocromil sodium prevents the release of inflammatory chemotactic…

THROMBOSTAT™ Parke-Davis Thrombin (Bovine Origin) Topical Hemostatic Action and Clinical Uses: Thrombostat is a protein substance produced through a conversion reaction in which prothrombin of bovine origin is activated by tissue thromboplastin in the presence of calcium chloride. Thrombin requires no intermediate physiological agent for its action. It clots the fibrinogen of the blood directly. Failure to clot blood occurs in the rare case where the primary clotting defect is…

THYROID HORMONE Parke-Davis Desiccated Thyroid Hypothyroidism Therapy Action and Clinical Uses: The principal pharmacologic effect of exogenous thyroid hormones is to increase the metabolic rate of body tissues. The normal thyroid gland contains approximately 200 g of levothyroxine (T 4)/g of gland, and 15 g of triiodothyronine (T 3)/g. The ratio of these two hormones in the circulation does not represent the ratio in the thyroid gland, since about 80%…

THIOTEPA Wyeth-Ayerst Cytotoxic Agent Action and Clinical Uses: Thiotepa is a cytotoxic agent of the polyfunctional alkylating type (more than one reactive ethylenimine group) related chemically and pharmacologically to nitrogen mustard. Its radiomimetic action is believed to occur through the release of ethylenimine radicals which, like irradiation, disrupt the bonds of DNA. One of the principal bond disruptions is initiated by alkylation of guanine at the N-7 position, which severs…

THROMBATE III® Bayer Antithrombin III (Human) Anticoagulant Action and Clinical Uses: Antithrombin III (AT-III), an alpha 2-glycoprotein of molecular weight 58 000, is normally present in human plasma at a concentration of approximately 12.5 mg/dL and is the major plasma inhibitor of thrombin. Inactivation of thrombin by AT-III occurs by formation of a covalent bond resulting in an inactive 1:1 stoichiometric complex between the two, involving an interaction of the active serine…

THEOCHRON® SR Riva Theophylline Bronchodilator Action and Clinical Theophylline is a bronchodilator which directly relaxes the smooth muscle of the bronchial airways and pulmonary and coronary blood vessels. These actions may be mediated through inhibition of phosphodiesterase and a resultant increase in intracellular cyclic AMP. Theophylline sustained release tablets produce peak blood levels of theophylline between 5 and 8 hours following dosing in adults. Once a steady state level has…