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DRISTAN® NASAL MIST/SPRAY Whitehall-Robins Pheniramine – Phenylephrine Nasal Decongestant Action And Clinical Pharmacology: Phenylephrine is a sympathomimetic agent that constricts the smaller arterioles of the nasal passages producing a gentle and predictable decongesting effect. Pheniramine is an antihistamine that controls rhinorrhea, sneezing and lacrimation associated with elevated histamine levels in disorders of the respiratory tract. Indications And Clinical Uses: Prompt temporary relief of nasal congestion due to colds, sinusitis, hay…

DOVONEX® Leo Calcipotriol Topical Nonsteroidal Antipsoriatic Action And Clinical Pharmacology: Calcipotriol is a nonsteroidal antipsoriatic agent, derived from the naturally occurring vitamin D. Calcipotriol exhibits a vitamin D-like effect by competing for the 1,25 (OH)2D3 receptor. Calcipotriol is as potent as 1,25 (OH)2D3, the naturally occurring active form of vitamin D, in regulating cell proliferation and cell differentiation, but much less active than 1,25 (OH)2D3 in its effect on calcium…

DOLOBID® Frosst Diflunisal Analgesic – Anti-inflammatory Action And Clinical Pharmacology: Diflunisal is a nonsteroidal drug with analgesic, anti-inflammatory and antipyretic properties. The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known; however, it appears to be a peripherally acting analgesic drug. Diflunisal is a prostaglandin synthetase inhibitor. In animals, prostaglandin sensitize afferent nerves and potentiate the action of bradykinin in inducing pain. Since prostaglandins are known…

DOXORUBICIN HYDROCHLORIDE INJECTION USP Novopharm Antineoplastic Agent Action And Clinical Pharmacology: Doxorubicin is the hydrochloric acid salt of a glycoside antibiotic produced by S. peucetius var. caesiu. Although not completely elucidated, the mechanism of action of doxorubicin is related mainly to its ability to bind specifically with DNA, by intercalation between adjacent base pairs of the double-helical structure, thereby inhibiting nucleic acid synthesis. Binding to cell membranes as well as…

DOXORUBICIN HCl FOR INJECTION USP Faulding Antineoplastic Agent Action And Clinical Pharmacology: The precise mechanism(s) of the antineoplastic action of doxorubicin is not fully understood. Experimental evidence indicates that doxorubicin forms a complex with DNA by intercalation between base pairs, causing inhibition of DNA synthesis and DNA-dependent RNA synthesis by the resulting template disordering and steric obstruction. Doxorubicin also inhibits protein synthesis. Doxorubicin is active throughout the cell cycle including…

DIXARIT® Boehringer Ingelheim Clonidine HCl Vascular Stabilizer for the Treatment of Menopausal Flushing Action And Clinical Pharmacology: Clonidine reduces the response of peripheral vessels to either vasoconstrictor or vasodilator stimuli. Clonidine, the active ingredient, is an a-adrenergic agonist which also has some a-adrenergic antagonist effects. Clonidine therapy has been shown to reduce the frequency, severity, and duration of flushing attacks associated with the menopausal syndrome. There is a gradual onset…

DOAN’S® Backache Pills Novartis Consumer Health Magnesium Salicylate Analgesic Indications And Clinical Uses: For quick relief of muscular backache pain. Manufacturers’ Warnings In Clinical States: Pregnancy and Lactation: Consult a physician before taking this drug during the last 3 months of pregnancy or if nursing. Package contains enough drug to seriously harm a child. Keep out of children’s reach. Children and teenagers should not use this medicine for chickenpox or…

DOBUTREX® Lilly Dobutamine HCl Sympathomimetic Action And Clinical Pharmacology: Dobutamine is a direct acting inotropic agent whose primary activity results from stimulation of the b-receptors of the heart while producing less marked chronotropic, hypertensive, arrhythmogenic or vasodilatory effects. It does not cause the release of endogenous norepinephrine as does dopamine. No specific effect on the renal vasculature has been observed. In both animal and human studies, dobutamine produces less increase…

DOBUTAMINE HYDROCHLORIDE INJECTION Novopharm Inotropic Action And Clinical Pharmacology: Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the b-receptors of the heart while producing less marked chronotropic, hypertensive, arrhythmogenic or vasodilatory effects. Dobutamine, unlike dopamine, does not cause the release of endogenous norepinephrine. No specific effect on the renal vasculature was observed. Dobutamine produces less increase in heart rate and less decrease in peripheral vascular…

DIPROLENE™ GLYCOL Schering Betamethasone Dipropionate Topical Corticosteroid Action And Clinical Pharmacology: Anti-inflammatory, antipruritic and vasoconstrictive. The propylene glycol components of the vehicle increase penetration and enhance the local effectiveness of betamethasone. Indications And Clinical Uses: For the relief of the inflammatory manifestations of resistant or severe psoriasis and corticosteroid-responsive dermatoses. Contra-Indications: In viral diseases including vaccinia, varicella, herpes simplex, and fungal infections; also, tuberculosis of the skin. Hypersensitivity to any…