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FLEXERIL® Frosst Cyclobenzaprine HCl Skeletal Muscle Relaxant Action And Clinical Pharmacology: Cyclobenzaprine relieves skeletal muscle spasm of local origin without interfering with muscle function. It is ineffective in muscle spasm due to CNS disease. Controlled clinical studies show that cyclobenzaprine improves the signs and the symptoms of skeletal muscle spasm. Pharmacokinetics: Cyclobenzaprine is well absorbed in man. After oral or i.v. doses (10 mg) of 4-labeled cyclobenzaprine to human subjects,…

FLOLAN® Glaxo Wellcome Epoprostenol Sodium Vasodilator Action And Clinical Pharmacology: Epoprostenol, also known as prostacyclin, PGl2 or PGX, a metabolite of arachidonic acid, is a naturally occurring prostaglandin. Epoprostenol has two major pharmacological actions: (1) direct vasodilation of pulmonary and systemic arterial vascular beds, and (2) inhibition of platelet aggregation. In animals, the vasodilatory effects of epoprostenol reduce right and left ventricular afterload and increase cardiac output and stroke volume….

FLONASE® Glaxo Wellcome Fluticasone Propionate Corticosteroid for Nasal Use Action And Clinical Pharmacology: Fluticasone is a potent anti-inflammatory steroid with strong topical and weak systemic activity. When administered intranasally in therapeutic doses, it has a direct anti-inflammatory action on the nasal mucosa, the mechanism of which is not yet completely defined. The onset of action is not immediate, and 2 to 3 days treatment may be required before maximum relief…

FLOMAX® Boehringer Ingelheim Tamsulosin HCl Selective Antagonist of Alpha1A-adrenoceptor Subtype in the Prostate Action And Clinical Pharmacology: Tamsulosin, an alpha1-adrenoceptor blocking agent, exhibits selectivity for alpha1 receptors in the human prostate. At least 3 discrete alpha1-adrenoreceptor subtypes have been identified: alpha1A, alpha1B and alpha1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptor in human prostate is of the alpha1A subtype. The symptoms associated with benign…

FLEET ENEMA® FLEET ENEMA® Mineral Oil Johnson & Johnson Merck Sodium Phosphates Mineral Oil Laxative Action And Clinical Pharmacology: Fleet Enema: Useful as a laxative in the relief of constipation, and as a bowel evacuant for a variety of diagnostic, surgical and therapeutic indications. Dibasic sodium phosphate and monobasic sodium phosphate are poorly absorbed from the gastrointestinal tract and retain water in the lumen of the intestine. When administered rectally…

FLEET® PHOSPHO®-SODA Johnson & Johnson• Merck Sodium Phosphates Laxative Action And Clinical Pharmacology: Depending on dosage, sodium phosphates oral solution is useful as a laxative in the relief of constipation, or as a bowel evacuant for a variety of diagnostic, surgical and therapeutic indications. Dibasic sodium phosphate and monobasic sodium phosphate are poorly absorbed from the gastrointestinal tract and retain water in the lumen of the intestine. When administered orally,…

FLAMAZINE® Smith & Nephew Silver Sulfadiazine Topical Antibacterial Action And Clinical Pharmacology: Silver sulfadiazine is released slowly from the cream, and thus rapid depletion of chloride and associated electrolyte disturbances are minimized. Silver sulfadiazine is not inhibited by PABA. In burned pigs, the absorption of silver was less than 1% of the applied dose, however 5 to 8% of the sulfadiazine was absorbed. There is very little penetration of the…

FLAMAZINE® C Smith & Nephew Silver Sulfadiazine – Chlorhexidine Digluconate Topical Antibacterial Action And Clinical Pharmacology: The mechanism of silver sulfadiazine’s antibacterial action has not been fully elucidated. After exposure to the drug, structural changes in the bacterial cell membrane occur, including distortion and enlargement of the cell and a weakening of the cell wall membrane. This is accompanied by reduced viability in sensitive strains. The silver sulfadiazine molecule dissociates…

FLAREX® Alcon Fluorometholone Acetate Corticosteroid Action And Clinical Pharmacology: Adrenocorticoids suppress the inflammatory response (edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, deposition of collagen and scar formation) to chemical, immunological or mechanical irritants. Adrenocorticoids may cause a rise in intraocular pressure in susceptible individuals. They are absorbed into aqueous humor, cornea, iris, choroid, ciliary body, and retina. Systemic absorption occurs but may be significant only at higher doses…

FLAXEDIL® Rh´ne-Poulenc Rorer Gallamine Triethiodide Muscle Relaxant Action And Clinical Pharmacology: Gallamine is a competitive neuromuscular blocking agent. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. Gallamine has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension. Very high doses cause histamine release. Following usual i.v. doses muscle relaxation occurs rapidly and reaches a…