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FLUVIRAL S/F® BioChem Vaccines Whole-Virion and Split-Virion Influenza Virus Vaccine, Inactivated Active Immunizing Agent Action And Clinical Pharmacology: Fluviral S/F, split-virion influenza vaccine, promotes an active immunization against influenza. Within 7 days after injection of the vaccine there is an increase in circulating antibody to the viral hemagglutination, and peripheral blood lymphocytes are primed to respond to in vitro stimulation by vaccine antigens. I.M. injection of inactivated vaccine leads to…

FLUVIRAL® BioChem Vaccines Influenza Virus Vaccine Trivalent, Inactivated Whole-Virion Active Immunizing Agent Action And Clinical Pharmacology: Fluviral whole virion influenza vaccine, promotes an active immunization against influenza. Within 7 days after injection of the vaccine there is an increase in circulating antibody to the viral hemagglutination, and peripheral blood lymphocytes are primed to respond to in vitro stimulation by vaccine antigens. I.M. injection of inactivated vaccine leads to the presence…

FLUOROURACIL ROCHE® Roche 5-Fluorouracil Antineoplastic Caution: 5-fluorouracil is a potent drug and should be prescribed only by physicians experienced with cancer chemotherapeutic drugs (see Precautions). Blood counts as well as renal and hepatic function tests should be performed regularly. Discontinue the drug if there is significant leukopenia (under 3 000/mm or granulocytopenia (under 1 500/mm. Action And Clinical Pharmacology: 5-Fluorouracil is a fluorinated pyrimidine antimetabolite which is structurally similar to…

FLUDARA® Berlex Canada Fludarabine Phosphate Antineoplastic Action And Clinical Pharmacology: Fludarabine is a fluorinated analog of adenine that is relatively resistant to deamination by adenosine deaminase. Fludarabine (2F-ara-AMP) is rapidly dephosphorylated to 2-fluoro-ara-A (2F-ara-A) and then phosphorylated intracellularly by deoxycytidine kinase to the active 2-fluoro-ara-ATP (2F-ara-ATP). The antitumor activity of this metabolite is the result of inhibition of DNA synthesis via inhibition of ribonucleotide reductase and DNA polymerase a. Maximum…

FLUOTIC® Hoechst Marion Roussel Sodium Fluoride Otospongiosis Therapy Action And Clinical Pharmacology: Sodium fluoride acts partly by reducing bone resorption in the bone remodeling cycle and partly by increasing bone deposition. In organ culture of otospongiotic bone removed at operation, sodium fluoride increased radioactive calcium uptake. Analysis of the fluoride content of otospongiotic bone showed a higher fluoride content in untreated patients, than in the endochrondral bone of the noninvolved…

FLUPHENAZINE General Monograph Antipsychotic Pharmacology: Fluphenazine is a short-acting piperazine phenothiazine. Phenothiazines are thought to elicit their antipsychotic effects via interference with central dopaminergic pathways in the mesolimbic zone of the brain. Extrapyramidal side effects are a result of interaction with dopaminergic pathways in the basal ganglia. Fluphenazine has alpha adrenergic blocking activity and can cause orthostatic hypotension. Compared to other phenothiazines, fluphenazine has weak anticholinergic, sedative and hypotensive activity,…

FLOVENT® Glaxo Wellcome Fluticasone Propionate Corticosteroid Action And Clinical Pharmacology: Fluticasone is a highly potent glucocorticoid anti-inflammatory steroid with strong topical and negligible systemic activity. When administered by inhalation at therapeutic dosages, it has a direct potent anti-inflammatory action within the lungs, resulting in reduced symptoms and exacerbations of asthma without the adverse effects observed when corticosteroids are administered systemically. In comparisons with beclomethasone dipropionate, fluticasone propionate has demonstrated greater…

FLORINEF® Roberts Fludrocortisone Acetate Addison’s Disease Therapy Action And Clinical Pharmacology: The physiologic action of fludrocortisone is similar to that of hydrocortisone. However, the effects of fludrocortisone, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. In small oral doses, fludrocortisone produces marked sodium retention and increased urinary potassium excretion. It also causes a rise in blood pressure, apparently because of these effects on electrolyte…

FLOXIN® Janssen-Ortho Ofloxacin Antibacterial Action And Clinical Pharmacology: Ofloxacin is a broad-spectrum, synthetic fluoroquinolone antibacterial agent for oral administration. Ofloxacin is thought to exert a bactericidal effect on susceptible bacterial cells by inhibiting the essential bacterial enzyme, DNA gyrase, a critical catalyst in the duplication, transcription and repair of bacteria. Pharmacokinetics: The pharmacokinetic profile of ofloxacin tablets is comparable to the profile of ofloxacin administered i.v. The bioavailability of ofloxacin…

FLUANXOL® DEPOT INJECTION FLUANXOL® TABLETS Lundbeck Flupenthixol Decanoate Flupenthixol Dihydrochloride Antipsychotic Action And Clinical Pharmacology: Flupenthixol is the decanoate ester of a thioxanthene derivative with antipsychotic properties. The esterification of flupenthixol results in the slow release of the drug from the injection site with consequent prolongation of duration of action. The onset of action usually occurs in the range of 24 to 72 hours after injection and the improvement of…