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GARASONE™ Ophthalmic/Otic Preparations Schering Betamethasone Sodium Phosphate – Gentamicin Sulfate Topical Corticosteroid – Antibiotic Action And Clinical Pharmacology: The anti-inflammatory activity of betamethasone is combined with the broad spectrum bactericidal activity of gentamicin. Betamethasone inhibits the inflammatory response of the eye and ear to irritating agents of a mechanical, chemical or immunological nature, while gentamicin is active in vitro against a wide variety of pathogenic gram-negative and gram-positive bacteria Indications…

FUNGIZONE® INTRAVENOUS Squibb Amphotericin B Antifungal Indications And Clinical Uses: Amphotericin B is specifically intended for the treatment of disseminated mycotic infections, including coccidioidomycosis; cryptococcosis (torulosis); disseminated candidiasis, histoplasmosis, South American leishmaniasis, North and South American blastomycosis; mucormycosis (phycomycosis) caused by species of the genera Mucor, Rhizopus, Absidia, Entomophthora, and Basidiobolus, sporotrichosis (S. schenckii), and aspergillosis (A. fumigatus). Other Clinical Uses: Limited studies have shown that amphotericin B powder for…

FULVICIN® U/F Schering Griseofulvin (Microsize) Antifungal Antibiotic Indications And Clinical Uses: Orally effective against superficial infections caused by those fungi responsible for dermatomycoses in man and animals, namely: M. canis, M. gypseum, M. audouini, E. floccosum, T. tonsurans, T. rubrum, T. mentagrophytes, T. megninii, T. gallinae, T. verrucosum, T. sulfureum, T. interdigitale, T. schoenleinii, T. crateriform. Griseofulvin is inactive against: C. albicans (monilia), C. neoformans, B. dermatitidis, A. israelii, H….

GAMIMUNE® N Bayer Immune Globulin (Human), I.V. Passive Immunizing Agent Action And Clinical Pharmacology: Primary Humoral Immunodeficiency: Gamimune N treated with solvent/detergent supplies a broad spectrum of opsonic and neutralizing IgG antibodies for the prevention or attenuation of a wide variety of infectious diseases. Since Gamimune N is administered i.v., essentially 100% of the infused IgG antibodies are immediately available in the recipient’s circulation. Studies using a modified i.v. immunoglobulin…

GARAMYCIN® Ophthalmic/Otic Preparations Schering Gentamicin Sulfate Topical Antibiotic Action And Clinical Pharmacology: Gentamicin, an aminoglycoside antibiotic, is active against the gram-positive bacteria commonly found in eye-ear infections: coagulase-positive and coagulase-negative Staphylococci; Group A beta-hemolytic and non-hemolytic Streptococci; and Diplococcus pneumoniae. Garamicin is also active against gram-negative bacteria including P. aeruginosa, indole-positive and indole-negative Proteus species, E. coli, species of the Klebsiella-Enterobacter-Serratia group, Citrobacter species, Salmonella and Shigella, Moraxella species, Providencia…

FUCIDIN® Tablets FUCIDIN® I.V. FUCIDIN® Suspension Leo Sodium Fusidate Fusidic Acid Antibiotic Action And Clinical Pharmacology: The antibacterial action of fusidic acid results from the inhibition of bacterial protein synthesis. The drug interferes with amino acid transfer from aminoacyl-sRNA to protein on the ribosomes. Fusidic acid may be bacteriostatic or bactericidal depending on inoculum size. Although bacterial cells stop dividing almost within 2 minutes after contact with the antibiotic in…

FROBEN® FROBEN SR® Knoll Flurbiprofen Nonsteroidal Anti-inflammatory Agent Action And Clinical Pharmacology: Flurbiprofen is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic activity. Although its mechanism of action has not been completely elucidated it has been shown to be an inhibitor of prostaglandin synthesis, specifically cyclo-oxygenase, and to some extent lipoxygenase, and is not due to pituitary-adrenal stimulation. Flurbiprofen is well absorbed and the rate of absorption is not altered…

FULVICIN® P/G Schering Griseofulvin (Ultramicrosize) Antifungal Antibiotic Indications And Clinical Uses: For the treatment of ringworm infections of the skin, hair and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, tinea capitis, tinea unguium (onychomycosis) when caused by susceptible strains of the following genera of fungi: T. rubrum, T. tonsurans, T. mentagrophytes, T. interdigitale, T. verrucosum, T. sulphureum, T. schoenleinii, T. megninii, T. gallinae, T. crateriform, M. audouini,…

FUCIDIN® Cream FUCIDIN® Ointment FUCIDIN® Intertulle Leo Fusidic Acid Sodium Fusidate Antibiotic Action And Clinical Pharmacology: Fusidic acid inhibits bacterial protein synthesis by interfering with amino acid transfer from aminoacyl-sRNA to protein on the ribosomes. Fusidic acid may be bacteriostatic or bactericidal depending on inoculum size. Although bacterial cells stop dividing almost within 2 minutes after contact with the antibiotic in vitro, DNA and RNA synthesis continue for 45 minutes…

FRISIUM® Hoechst Marion Roussel Clobazam Anticonvulsant for Adjunctive Therapy Action And Clinical Pharmacology: Clobazam is a 1,5-benzodiazepine with anticonvulsant properties. In general, the mode of antiepileptic action of clobazam is probably largely analogous to that of the 1,4-benzodiazepines . The differences between clobazam (a 1,5-benzodiazepine) and the 1,4-benzodiazepines in terms of therapeutic efficacy and neurotoxicity are possibly due to the variation in degree of the agonist action at the high…